Identification of a Novel Pleiotropic Transcriptional Regulator Involved in Sporulation and Secondary Metabolism Production in Chaetomium globosum

• Published in: International journal of molecular sciences Vol. 23; no. 23; p. 14849
• Main Authors: Zhao, Shanshan, Zhang, Kai, Lin, Congyu, Cheng, Ming, Song, Jinzhu, Ru, Xin, Wang, Zhengran, Wang, Wan, Yang, Qian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.11.2022; MDPI
• Subjects: Antiparasitic agents; Biological control; Biosynthesis; chaetoglobosin A; Chaetomium - metabolism; Chaetomium globosum; Commercialization; Complementation; Disruption; Enzymes; Fungi; Gene regulation; Genes; Genomes; Metabolism; Metabolites; metabolome; Plasmids; pleiotropic regulator; Secondary Metabolism - genetics; Sporulation; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; chaetoglobosin A; Chaetomium globosum; metabolome; pleiotropic regulator; sporulation

Chaetoglobosin A (CheA), a well-known macrocyclic alkaloid with prominently highly antimycotic, antiparasitic, and antitumor properties, is mainly produced by . However, a limited understanding of the transcriptional regulation of CheA biosynthesis has hampered its application and commercialization...