Nuclear translocation of extracellular superoxide dismutase
Histochemical examination of mouse tissues showed nuclear staining of extracellular superoxide dismutase (EC-SOD), and the nuclear translocation of EC-SOD was also confirmed in cultured cells that had been transfected with its gene, as shown by immunohistochemistry and Western blot analysis. The EC-...
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| Published in | Biochemical and biophysical research communications Vol. 296; no. 1; pp. 54 - 61 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
09.08.2002
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| Abstract | Histochemical examination of mouse tissues showed nuclear staining of extracellular superoxide dismutase (EC-SOD), and the nuclear translocation of EC-SOD was also confirmed in cultured cells that had been transfected with its gene, as shown by immunohistochemistry and Western blot analysis. The EC-SOD which was secreted into the medium was incorporated into 3T3-L1 cells and a significant fraction of the material taken up was localized in the nucleus. Site-directed mutagenesis indicated that the heparin-binding domain of EC-SOD functions as the nuclear localization signal. These results suggest that the mechanism of the nuclear transport of EC-SOD involves a series of N-terminal signal peptide- and C-terminal heparin-binding domain-dependent processes of secretion, re-uptake and the subsequent nuclear translocation. The findings herein provide support for the view that the role of EC-SOD is to protect the genome DNA from damage by reactive oxygen species and/or the transcriptional regulation of redox-sensitive gene expression. |
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| AbstractList | Histochemical examination of mouse tissues showed nuclear staining of extracellular superoxide dismutase (EC-SOD), and the nuclear translocation of EC-SOD was also confirmed in cultured cells that had been transfected with its gene, as shown by immunohistochemistry and Western blot analysis. The EC-SOD which was secreted into the medium was incorporated into 3T3-L1 cells and a significant fraction of the material taken up was localized in the nucleus. Site-directed mutagenesis indicated that the heparin-binding domain of EC-SOD functions as the nuclear localization signal. These results suggest that the mechanism of the nuclear transport of EC-SOD involves a series of N-terminal signal peptide- and C-terminal heparin-binding domain-dependent processes of secretion, re-uptake and the subsequent nuclear translocation. The findings herein provide support for the view that the role of EC-SOD is to protect the genome DNA from damage by reactive oxygen species and/or the transcriptional regulation of redox-sensitive gene expression. |
| Author | Imazeki, Nobuo Ookawara, Tomomi Suzuki, Keiichiro Ikeda, Yoshitaka Li Ji, Li Matsubara, Osamu Kizaki, Takako Ohno, Hideki Takayama, Eiji Taniguchi, Naoyuki Tadakuma, Takushi |
| Author_xml | – sequence: 1 givenname: Tomomi surname: Ookawara fullname: Ookawara, Tomomi organization: Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan – sequence: 2 givenname: Takako surname: Kizaki fullname: Kizaki, Takako organization: Department of Molecular Preventive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan – sequence: 3 givenname: Eiji surname: Takayama fullname: Takayama, Eiji organization: Departments of Parasitology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan – sequence: 4 givenname: Nobuo surname: Imazeki fullname: Imazeki, Nobuo organization: Departments of Pathology II, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan – sequence: 5 givenname: Osamu surname: Matsubara fullname: Matsubara, Osamu organization: Departments of Pathology II, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan – sequence: 6 givenname: Yoshitaka surname: Ikeda fullname: Ikeda, Yoshitaka organization: Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan – sequence: 7 givenname: Keiichiro surname: Suzuki fullname: Suzuki, Keiichiro organization: Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan – sequence: 8 givenname: Li surname: Li Ji fullname: Li Ji, Li organization: Department of Kinesiology, School of Education, University of Wisconsin Madison, Madison, WI 53706-1189, USA – sequence: 9 givenname: Takushi surname: Tadakuma fullname: Tadakuma, Takushi organization: Departments of Parasitology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan – sequence: 10 givenname: Naoyuki surname: Taniguchi fullname: Taniguchi, Naoyuki email: proftani@biochem.med.osaka-u.ac.jp organization: Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan – sequence: 11 givenname: Hideki surname: Ohno fullname: Ohno, Hideki organization: Department of Molecular Preventive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan |
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| Keywords | Nuclear localization signal Extracellular superoxide dismutase Heparin binding domain Secretion ROS |
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| SubjectTerms | 3T3 Cells Animals Blotting, Western Cell Nucleus - metabolism COS Cells Extracellular superoxide dismutase Heparin - metabolism Heparin binding domain Immunohistochemistry Mice Nuclear localization signal Nuclear Localization Signals Plasmids Protein Transport ROS Secretion Superoxide Dismutase - chemistry Superoxide Dismutase - genetics Superoxide Dismutase - metabolism |
| Title | Nuclear translocation of extracellular superoxide dismutase |
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