Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 161; no. 4; pp. 1257 - 1269.e13
• Main Authors: Yang, Keli, Niu, Junkun, Zuo, Tao, Sun, Yang, Xu, Zhilu, Tang, Whitney, Liu, Qin, Zhang, Jingwan, Ng, Enders K.W., Wong, Simon K.H., Yeoh, Yun Kit, Chan, Paul K.S., Chan, Francis K.L., Miao, Yinglei, Ng, Siew C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2021
• Subjects: Adolescent; Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - microbiology; Diabetes Mellitus, Type 2 - virology; Dysbiosis; Feces - microbiology; Feces - virology; Female; Gastrointestinal Microbiome; Hong Kong; Host-Pathogen Interactions; Humans; Intestines - microbiology; Intestines - virology; Male; Metabolic Diseases; Metagenome; Metagenomics; Microbiota; Middle Aged; Obesity - diagnosis; Obesity - microbiology; Obesity - virology; Virome - genetics; Weight; Young Adult; Hong Kong; PCoA; Metagenomics; T2DM; KM; ORF; HK; Metabolic Diseases; MDA; PERMANOVA; SCFA; Weight; Microbiota; ObT2; Ob-non-T2; VLP; BMI

Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM. Ther...