Walking Training Increases microRNA-126 Expression and Muscle Capillarization in Patients with Peripheral Artery Disease

• Published in: Genes Vol. 14; no. 1; p. 101
• Main Authors: da Silva, Jr, Natan D, Andrade-Lima, Aluisio, Chehuen, Marcel R, Leicht, Anthony S, Brum, Patricia C, Oliveira, Edilamar M, Wolosker, Nelson, Pelozin, Bruno R A, Fernandes, Tiago, Forjaz, Cláudia L M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.12.2022; MDPI
• Subjects: Angiogenesis; Biopsy; capillarization; Clinical trials; Endothelium; Fitness equipment; Gene expression; Glycerol; Humans; intermittent claudication; Intermittent Claudication - metabolism; Ischemia; Kinases; Male; Medical research; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular biology; Muscle, Skeletal - metabolism; Pain; Peripheral Arterial Disease - genetics; Peripheral Arterial Disease - metabolism; physical exercise; Signal transduction; Software; Vascular diseases; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; VEGF; Vein & artery diseases; Walking; Walking - physiology; United States > US; microRNA; physical exercise; capillarization; VEGF; intermittent claudication

Patients with peripheral artery disease (PAD) have reduced muscle capillary density. Walking training (WT) is recommended for PAD patients. The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role of miRNA-126 and the vascular e...