Effects of β-Carotene and Its Cleavage Products in Primary Pneumocyte Type II Cells

• Published in: Antioxidants Vol. 6; no. 2; p. 37
• Main Authors: Haider, Cornelia, Ferk, Franziska, Bojaxhi, Ekramije, Martano, Giuseppe, Stutz, Hanno, Bresgen, Nikolaus, Knasmüller, Siegfried, Alija, Avdulla, Eckl, Peter M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.05.2017; MDPI
• Subjects: Antioxidants; apo-8′carotenal; Apoptosis; Asbestos; Biotransformation; Cell density; Chromosome aberrations; Cleavage; Comet assay; Cytotoxicity; dimethoxy-naphthoquinone; DNA damage; Genotoxicity; Hepatocytes; Liver; Lung cancer; Micronuclei; Oxidative stress; pneumocytes; Quinones; Redox properties; Vitamin A; Workers; β-Carotene; β-carotene cleavage products; dimethoxy-naphthoquinone; apo-8′carotenal; apoptosis; β-carotene; micronuclei; β-carotene cleavage products; Comet assay; pneumocytes

β-Carotene has been shown to increase the risk of developing lung cancer in smokers and asbestos workers in two large scale trails, the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol Beta-carotene Cancer Prevention Trial (ATBC). Based on this observation, it was proposed t...