Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing

• Published in: International journal of molecular sciences Vol. 23; no. 24; p. 16207
• Main Authors: Wallenwein, Chantal M, Weigel, Verena, Hofhaus, Götz, Dhakal, Namrata, Schatton, Wolfgang, Gelperina, Svetlana, Groeber-Becker, Florian K, Dressman, Jennifer, Wacker, Matthias G
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.12.2022; MDPI
• Subjects: Antiinfectives and antibacterials; Aqueous environments; Biocompatibility; Cellulose; Collagen; Collagen - metabolism; Drug Development; Environmental degradation; Freeze drying; Hyaluronic acid; Hyaluronic Acid - chemistry; hydrogel; Hydrogels; Hydrogels - chemistry; Inflammation; Lecithin; liposomes; marine sponge collagen; Moisture content; Oxidation; Particle size; Pharmaceuticals; Phosphatidylcholine; Proteolysis; Proteolytic enzymes; rifampicin; Rifampin; Rifampin - pharmacology; Sucrose; Water content; Wound Healing; rifampicin; wound healing; hydrogel; liposomes; marine sponge collagen; hyaluronic acid

Chronic wounds exhibit elevated levels of inflammatory cytokines, resulting in the release of proteolytic enzymes which delay wound-healing processes. In recent years, rifampicin has gained significant attention in the treatment of chronic wounds due to an interesting combination of antibacterial an...