The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 3; pp. 677 - 684
• Main Authors: Zhang, Qiumei, Shen, Qiuge, Xu, Zhansheng, Chen, Min, Cheng, Lina, Zhai, Jinguo, Gu, Huang, Bao, Xin, Chen, Xiongying, Wang, Keqin, Deng, Xiaoxiang, Ji, Feng, Liu, Chuanxin, Li, Jun, Dong, Qi, Chen, Chuansheng
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2012; Nature Publishing Group
• Subjects: Adult; Alleles; Antipsychotics; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - psychology; Calcium Channels, L-Type - genetics; Drug abuse; Female; Genes; Genotype; Head injuries; Humans; Male; Medicine; Medicine & Public Health; Memory; Memory, Short-Term - physiology; Mental disorders; Neuropsychological Tests; Neurosciences; Original; original-article; Patients; Pharmacotherapy; Polymorphism; Polymorphism, Single Nucleotide; Psychiatry; Psychotropic drugs; Schizophrenia; Schizophrenia - genetics; Schizophrenic Psychology; Signal transduction; Beijing China; China; polymorphism; schizophrenia; CACNA1C; working memory

CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP). However, its role in working memory, a cognitive function that is impaired in both diseases, is not clear. Using three samples, including healthy controls, patients with SCZ, and...