Isolation, identification, and metabolism of (23S,25R)-25-hydroxyvitamin D3 26,23-lactol. A biosynthetic precursor of (23S,25R)-25-hydroxyvitamin D3 26,23-lactone

• Published in: The Journal of biological chemistry Vol. 259; no. 2; pp. 884 - 889
• Main Authors: Yamada, S, Nakayama, K, Takayama, H, Shinki, T, Takasaki, Y, Suda, T
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 25.01.1984; American Society for Biochemistry and Molecular Biology
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Calcifediol - analogs & derivatives; Calcifediol - isolation & purification; Calcifediol - metabolism; Chickens; Chromatography, High Pressure Liquid; Coenzymes, vitamins; Fundamental and applied biological sciences. Psychology; Hydroxycholecalciferols - metabolism; Kidney - metabolism; Mass Spectrometry; Other biological molecules; Stereoisomerism; Vertebrata; Homogenate; Vitamin; Biosynthesis; Chicken; Aves; Metabolism; Chemical synthesis; Kidney

23S,25R,26-Trihydroxyvitamin D3 and (23S,25R)-25-hydroxyvitamin D3 26,23-lactol were chemically synthesized, and the metabolism of the two compounds to (23S,25R)-25-hydroxyvitamin D3 26,23-lactone in chick kidney homogenates was studied. 23S,25R,26-trihydroxyvitamin D3 was efficiently metabolized to...