Cytochrome P450 Enzymes and Drug Metabolism in Humans

• Published in: International journal of molecular sciences Vol. 22; no. 23; p. 12808
• Main Authors: Zhao, Mingzhe, Ma, Jingsong, Li, Mo, Zhang, Yingtian, Jiang, Bixuan, Zhao, Xianglong, Huai, Cong, Shen, Lu, Zhang, Na, He, Lin, Qin, Shengying
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.11.2021; MDPI
• Subjects: Animals; Cancer therapies; Clinical outcomes; Cytochrome; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Drugs; Enzymes; Epigenetics; Humans; Inactivation, Metabolic; Ligands; Metabolic Clearance Rate; Metabolism; Metabolites; Pharmaceutical Preparations - metabolism; Pharmaceuticals; Polymorphism, Genetic; Review; Xenobiotics - metabolism; protein structure; cytochrome P450; genetic polymorphisms; drug metabolism

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to...