MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1

• Published in: The Journal of cell biology Vol. 212; no. 7; pp. 829 - 843
• Main Authors: Zhao, Wei, Liu, Jie, Zhang, Xiaoming, Deng, Lih-Wen
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 28.03.2016; The Rockefeller University Press
• Subjects: Cell cycle; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell division; Cell Line, Tumor; Cell Polarity; Chromosomes; Cytosol - enzymology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Enzymes; Genomics; HEK293 Cells; Humans; Microtubule-Organizing Center - enzymology; Mitosis; Mutation; Phosphorylation; Polo-Like Kinase 1; Protein Aggregates; Protein Binding; Protein Interaction Domains and Motifs; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; RNA Interference; Signal Transduction; Spindle Apparatus - metabolism; Time Factors; Transfection

Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of genomic stability. Perturbation of this process often leads to severe mitotic failure, contributing to tumorigenesis. MLL5 has been demonstrated to play vital roles in cell cycle progression and the mai...