Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation

The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 ( 1 ), procyanidin A2 ( 2 ), procya...

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Published in	Archives of pharmacal research Vol. 37; no. 11; pp. 1403 - 1410
Main Authors	Park, Hee-Jung, Kim, Su-Yeon, Song, Na-Young, Cho, Jin-Gyeong, Kang, Ji-Hyun, Jeong, Tae-Sook, Lee, Dae-Young, Kim, Geum-Soog, Kim, Yong-Bum, Kang, Hee-Cheol, Baek, Nam-In
Format	Journal Article
Language	English
Published	Heidelberg Pharmaceutical Society of Korea 01.11.2014 대한약학회
Subjects	Antioxidants - isolation & purification Antioxidants - pharmacology butanol butylated hydroxytoluene chemical structure ethyl acetate inhibitory concentration 50 Lauraceae - chemistry Lipoproteins, LDL - chemistry low density lipoprotein Machilus Medicine methanol Molecular Structure nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular oxidation Oxidation-Reduction Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Stems - chemistry Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology procyanidins Research Article stemwood 약학 Low-density lipoprotein Procyanidin
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ISSN	0253-6269 1976-3786 1976-3786
DOI	10.1007/s12272-013-0304-2

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Abstract	The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 ( 1 ), procyanidin A2 ( 2 ), procyanidin B7 ( 3 ), cinnamtannin B1 ( 4 ), and aesculitannin B ( 5 ), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC 50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively.
AbstractList	The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 ( 1 ), procyanidin A2 ( 2 ), procyanidin B7 ( 3 ), cinnamtannin B1 ( 4 ), and aesculitannin B ( 5 ), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC 50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively. The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC₅₀ values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively. The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively. The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively.The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively. The stem wood of Machilus japonica Siebold &Zucc were extracted with 80 % aqueous MeOH, and theconcentrated extract was successively partitioned with ethylacetate (EtOAc), normal butanol, and water. From theEtOAc fraction, five procyanidins, procyanidin A1 (1),procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1(4), and aesculitannin B (5), were isolated. Their chemicalstructures were identified through spectroscopic data analysesincluding NMR, MS, and IR. This is the first time any ofthese compounds have been isolated from this plant. Thecompounds were evaluated for inhibition activity on LDLoxidation. All of these compounds and the positive control,BHT, showed a very high inhibition effect with IC50 valuesof 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 lM, respectively. KCI Citation Count: 4
Author	Kim, Yong-Bum Park, Hee-Jung Jeong, Tae-Sook Kim, Su-Yeon Kang, Ji-Hyun Lee, Dae-Young Baek, Nam-In Song, Na-Young Kim, Geum-Soog Cho, Jin-Gyeong Kang, Hee-Cheol
Author_xml	– sequence: 1 givenname: Hee-Jung surname: Park fullname: Park, Hee-Jung organization: Oriental Medicinal Materials & Processing, Graduate School of Biotechnology, Kyung Hee University – sequence: 2 givenname: Su-Yeon surname: Kim fullname: Kim, Su-Yeon organization: Oriental Medicinal Materials & Processing, Graduate School of Biotechnology, Kyung Hee University – sequence: 3 givenname: Na-Young surname: Song fullname: Song, Na-Young organization: Oriental Medicinal Materials & Processing, Graduate School of Biotechnology, Kyung Hee University – sequence: 4 givenname: Jin-Gyeong surname: Cho fullname: Cho, Jin-Gyeong organization: Oriental Medicinal Materials & Processing, Graduate School of Biotechnology, Kyung Hee University – sequence: 5 givenname: Ji-Hyun surname: Kang fullname: Kang, Ji-Hyun organization: National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology – sequence: 6 givenname: Tae-Sook surname: Jeong fullname: Jeong, Tae-Sook organization: National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology – sequence: 7 givenname: Dae-Young surname: Lee fullname: Lee, Dae-Young organization: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA – sequence: 8 givenname: Geum-Soog surname: Kim fullname: Kim, Geum-Soog organization: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA – sequence: 9 givenname: Yong-Bum surname: Kim fullname: Kim, Yong-Bum organization: Technology Services Division, National Institute of Horticultural and Herbal Science, RDA – sequence: 10 givenname: Hee-Cheol surname: Kang fullname: Kang, Hee-Cheol organization: R&D Center, GFC Co., Ltd – sequence: 11 givenname: Nam-In surname: Baek fullname: Baek, Nam-In email: nibaek@khu.ac.kr organization: Oriental Medicinal Materials & Processing, Graduate School of Biotechnology, Kyung Hee University
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Cites_doi	10.1021/jf0300184 10.1021/jf9810517 10.1021/jf9709156 10.1021/jf000363i 10.1016/S0031-9422(00)90571-5 10.1016/S0005-2760(96)00154-3 10.1271/bbb.110085 10.1016/S0024-3205(00)00771-2 10.5053/ejobios.2010.4.0.6 10.1248/cpb.49.551 10.1016/j.chroma.2007.11.028 10.1021/jf050418m 10.1016/j.bmc.2004.06.001 10.1021/np9000653 10.1046/j.1523-1747.1999.00532.x 10.1016/j.foodchem.2007.05.022 10.1246/bcsj.49.3564 10.1046/j.1600-0749.2003.00093.x 10.1016/S0031-9422(98)00736-5
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References	Liu, Xie, Cao, Yang, Xu, Guo (CR12) 2007; 105 Lee, Lin, Chen (CR11) 2009; 72 Schnitzer, Pinchuk, Bor, Fainaru, Lichtenberg (CR16) 1997; 1344 Takahashi, Kamiya, Hasegawa, Yokoo (CR18) 1999; 112 Khien, Huy, Huong (CR7) 2009; 25 Toshihiko, Motoh, Takatoshi, Tomomasa, Hiroshi, Yukihiro (CR20) 2003; 51 Yanagida, Kanda, Tanabe, Matsudaira, Cordeiro (CR22) 2000; 48 Kohler, Wray, Winterhalter (CR9) 2008; 1177 Saito, Hosoyama, Ariga, Kataoka, Yamaji (CR15) 1998; 46 Jeong, Kim, Kim, Cho, Bae, Lee (CR5) 2004; 12 Koga, Moro, Nakamori, Yamakoshi, Hosoyama, Kataoka, Ariga (CR8) 1999; 47 Yamakoshi, Otsuka, Sano, Tokutake, Saito, Kikuchi, Kubota (CR21) 2003; 16 Daisuke, Keiko, Mitsuru (CR2) 1976; 49 Kamiya, Watanabe, Endang, Umar, Satake (CR6) 2001; 49 Shoji, Masumoto, Moriichi, Kobori, Kanda, Shinmoto, Tsushida (CR17) 2005; 53 Gonzalez-Coloma, Escoubas, Mizutani, Lajide (CR3) 1994; 3 Carini, Aldini, Bombardelli, Morazzoni, Facino (CR1) 2000; 67 Lou, Yoshimitsu, Tsutomu, Masaru, Hideoki, Syuichi (CR13) 1999; 51 Lee (CR10) 2003 Moon, Yim, Song, Lee, Hyun (CR14) 2010; 4 Tomochika, Shimizu-Ibuka, Tamura, Mura, Abe, Onose, Arai (CR19) 2011; 75 Hong, Byun, Kim (CR4) 1994 H Lou (304_CR13) 1999; 51 K Tomochika (304_CR19) 2011; 75 T Shoji (304_CR17) 2005; 53 JY Moon (304_CR14) 2010; 4 T Takahashi (304_CR18) 1999; 112 S Toshihiko (304_CR20) 2003; 51 K Kamiya (304_CR6) 2001; 49 T Koga (304_CR8) 1999; 47 M Saito (304_CR15) 1998; 46 T Daisuke (304_CR2) 1976; 49 PV Khien (304_CR7) 2009; 25 N Kohler (304_CR9) 2008; 1177 E Schnitzer (304_CR16) 1997; 1344 SC Hong (304_CR4) 1994 TB Lee (304_CR10) 2003 SS Lee (304_CR11) 2009; 72 A Yanagida (304_CR22) 2000; 48 T-S Jeong (304_CR5) 2004; 12 L Liu (304_CR12) 2007; 105 M Carini (304_CR1) 2000; 67 J Yamakoshi (304_CR21) 2003; 16 A Gonzalez-Coloma (304_CR3) 1994; 3
References_xml	– year: 2003 ident: CR10 publication-title: In coloured flora of Korea – volume: 51 start-page: 3806 year: 2003 end-page: 3813 ident: CR20 article-title: Isolation and structural elucidation of some procyanidins from apple by low-temperature nuclear magnetic resonance publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf0300184 – volume: 47 start-page: 1892 year: 1999 end-page: 1897 ident: CR8 article-title: Increase of antioxidative potential of rat plasma by oral administration of protoancyanidin-rich extract from grape seeds publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9810517 – volume: 46 start-page: 1460 year: 1998 end-page: 1464 ident: CR15 article-title: Antiulcer activity of grape seeds extract and procyanidins publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9709156 – volume: 48 start-page: 5666 year: 2000 end-page: 5671 ident: CR22 article-title: Inhibitory effects of apple polyphenols and related compounds on cariogenic factors of mutans streptococci publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf000363i – volume: 3 start-page: 607 year: 1994 end-page: 610 ident: CR3 article-title: Insect growth inhibitors from publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)90571-5 – volume: 1344 start-page: 300 year: 1997 end-page: 311 ident: CR16 article-title: The effect of albumin on copper-induced LDL oxidation publication-title: Biochimica Biophysica Acta doi: 10.1016/S0005-2760(96)00154-3 – volume: 75 start-page: 1644 year: 2011 end-page: 1648 ident: CR19 article-title: Effect of peanut-skin procyanidin A1 on degranulation of RBL-2H3 Cells publication-title: Bioscience, Biotechnology, and Biochemistry doi: 10.1271/bbb.110085 – volume: 67 start-page: 1799 year: 2000 end-page: 1814 ident: CR1 article-title: UVB-induced hemolysis of rat erythrocytes: protective effect of procyanidin from grape seeds publication-title: Life Sciences doi: 10.1016/S0024-3205(00)00771-2 – volume: 4 start-page: 41 year: 2010 end-page: 53 ident: CR14 article-title: Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants publication-title: EurAsian Journal of BioSciences doi: 10.5053/ejobios.2010.4.0.6 – volume: 49 start-page: 551 year: 2001 end-page: 557 ident: CR6 article-title: Studies on the constituents of bark of Moldenke publication-title: Chememical & Pharmaceutical Bulletin doi: 10.1248/cpb.49.551 – volume: 1177 start-page: 114 year: 2008 end-page: 125 ident: CR9 article-title: Preparative isolation of procyanidins from grape seed extracts by high-speed counter-current chromatography publication-title: Journal of Chromatography A doi: 10.1016/j.chroma.2007.11.028 – volume: 53 start-page: 6105 year: 2005 end-page: 6111 ident: CR17 article-title: Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf050418m – volume: 12 start-page: 4017 year: 2004 end-page: 4023 ident: CR5 article-title: Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation publication-title: Bioorganic & Medicinal Chemistry doi: 10.1016/j.bmc.2004.06.001 – year: 1994 ident: CR4 publication-title: In colored illustrations of trees and shrubs in Korea – volume: 25 start-page: 81 year: 2009 end-page: 83 ident: CR7 article-title: Chemical composition of essential oil of Siebold & Zucc. (Lauraceae) from Vietnam publication-title: VNU Journal of Science Natural Sciences and Technology – volume: 72 start-page: 1249 year: 2009 end-page: 1252 ident: CR11 article-title: Three adducts of butenolide and apigenin glycoside from the leaves of publication-title: Journal of Natural Products doi: 10.1021/np9000653 – volume: 112 start-page: 310 year: 1999 end-page: 316 ident: CR18 article-title: Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo publication-title: Journal of Investigative Dermatology doi: 10.1046/j.1523-1747.1999.00532.x – volume: 105 start-page: 1446 year: 2007 end-page: 1451 ident: CR12 article-title: A-type procyanidins from pericarp with antioxidant activity publication-title: Food Chemistry doi: 10.1016/j.foodchem.2007.05.022 – volume: 49 start-page: 3564 year: 1976 end-page: 3566 ident: CR2 article-title: Studies on lignoids in . II. Studies on lignans in the leaves of Sieb. et Zucc publication-title: Bulletin of the Chemical Society of Japan doi: 10.1246/bcsj.49.3564 – volume: 16 start-page: 629 year: 2003 end-page: 638 ident: CR21 article-title: Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds publication-title: Pigment Cell Research doi: 10.1046/j.1600-0749.2003.00093.x – volume: 51 start-page: 297 year: 1999 end-page: 308 ident: CR13 article-title: A-type proanthocyanidins from peanut skins publication-title: Phytochemistry doi: 10.1016/S0031-9422(98)00736-5 – volume: 1344 start-page: 300 year: 1997 ident: 304_CR16 publication-title: Biochimica Biophysica Acta doi: 10.1016/S0005-2760(96)00154-3 – volume-title: In coloured flora of Korea year: 2003 ident: 304_CR10 – volume: 12 start-page: 4017 year: 2004 ident: 304_CR5 publication-title: Bioorganic & Medicinal Chemistry doi: 10.1016/j.bmc.2004.06.001 – volume: 75 start-page: 1644 year: 2011 ident: 304_CR19 publication-title: Bioscience, Biotechnology, and Biochemistry doi: 10.1271/bbb.110085 – volume: 67 start-page: 1799 year: 2000 ident: 304_CR1 publication-title: Life Sciences doi: 10.1016/S0024-3205(00)00771-2 – volume: 46 start-page: 1460 year: 1998 ident: 304_CR15 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9709156 – volume: 3 start-page: 607 year: 1994 ident: 304_CR3 publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)90571-5 – volume: 16 start-page: 629 year: 2003 ident: 304_CR21 publication-title: Pigment Cell Research doi: 10.1046/j.1600-0749.2003.00093.x – volume: 51 start-page: 297 year: 1999 ident: 304_CR13 publication-title: Phytochemistry doi: 10.1016/S0031-9422(98)00736-5 – volume: 25 start-page: 81 year: 2009 ident: 304_CR7 publication-title: VNU Journal of Science Natural Sciences and Technology – volume: 1177 start-page: 114 year: 2008 ident: 304_CR9 publication-title: Journal of Chromatography A doi: 10.1016/j.chroma.2007.11.028 – volume-title: In colored illustrations of trees and shrubs in Korea year: 1994 ident: 304_CR4 – volume: 105 start-page: 1446 year: 2007 ident: 304_CR12 publication-title: Food Chemistry doi: 10.1016/j.foodchem.2007.05.022 – volume: 49 start-page: 551 year: 2001 ident: 304_CR6 publication-title: Chememical & Pharmaceutical Bulletin doi: 10.1248/cpb.49.551 – volume: 4 start-page: 41 year: 2010 ident: 304_CR14 publication-title: EurAsian Journal of BioSciences doi: 10.5053/ejobios.2010.4.0.6 – volume: 51 start-page: 3806 year: 2003 ident: 304_CR20 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf0300184 – volume: 53 start-page: 6105 year: 2005 ident: 304_CR17 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf050418m – volume: 48 start-page: 5666 year: 2000 ident: 304_CR22 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf000363i – volume: 49 start-page: 3564 year: 1976 ident: 304_CR2 publication-title: Bulletin of the Chemical Society of Japan doi: 10.1246/bcsj.49.3564 – volume: 72 start-page: 1249 year: 2009 ident: 304_CR11 publication-title: Journal of Natural Products doi: 10.1021/np9000653 – volume: 112 start-page: 310 year: 1999 ident: 304_CR18 publication-title: Journal of Investigative Dermatology doi: 10.1046/j.1523-1747.1999.00532.x – volume: 47 start-page: 1892 year: 1999 ident: 304_CR8 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9810517
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Snippet	The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl... The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl... The stem wood of Machilus japonica Siebold &Zucc were extracted with 80 % aqueous MeOH, and theconcentrated extract was successively partitioned with...
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SubjectTerms	Antioxidants - isolation & purification Antioxidants - pharmacology butanol butylated hydroxytoluene chemical structure ethyl acetate inhibitory concentration 50 Lauraceae - chemistry Lipoproteins, LDL - chemistry low density lipoprotein Machilus Medicine methanol Molecular Structure nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular oxidation Oxidation-Reduction Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Stems - chemistry Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology procyanidins Research Article stemwood 약학
Title	Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation
URI	https://link.springer.com/article/10.1007/s12272-013-0304-2 https://www.ncbi.nlm.nih.gov/pubmed/24297667 https://www.proquest.com/docview/1620024473 https://www.proquest.com/docview/1733507422 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001927941
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