Autophagosome maturation: An epic journey from the ER to lysosomes

• Published in: The Journal of cell biology Vol. 218; no. 3; pp. 757 - 770
• Main Authors: Zhao, Yan G., Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.03.2019
• Subjects: Animals; Autophagic Cell Death; Autophagosomes - metabolism; Autophagosomes - pathology; Autophagy; Biological Transport, Active; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - pathology; Humans; Lysosomal storage diseases; Lysosomes; Lysosomes - metabolism; Lysosomes - pathology; Maturation; Molecular modelling; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurological diseases; Nutrient availability; Pathogenesis; Phagocytosis; Phagosomes; Reviews; SNAP receptors; Tethering; Vesicles

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and their delivery to lysosomes for degradation. In multicellular organisms, nascent autophagosomes fuse with vesicles originating from endolysosomal compartments before forming degradative autolysos...