The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

• Published in: The Journal of cell biology Vol. 216; no. 2; pp. 425 - 439
• Main Authors: De, Mithu, Oleskie, Austin N, Ayyash, Mariam, Dutta, Somnath, Mancour, Liliya, Abazeed, Mohamed E, Brace, Eddy J, Skiniotis, Georgios, Fuller, Robert S
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.02.2017; The Rockefeller University Press
• Subjects: Adenosine Triphosphate - metabolism; Calcium-Binding Proteins - chemistry; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cellular biology; Endosomes - metabolism; Eukaryotes; Genes; Genotype; Golgi Apparatus - metabolism; Intracellular Membranes - metabolism; Membrane Fusion; Membranes; Multiprotein Complexes; Mutation; Phenotype; Phosphatidic Acids - metabolism; Phosphatidylinositols - metabolism; Phosphorylation; Protein Binding; Protein Folding; Protein Interaction Domains and Motifs; Protein Transport; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Signal Transduction; Structure-Activity Relationship; Time Factors; Yeast

Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. U...