Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology

• Published in: Diabetologia Vol. 61; no. 1; pp. 158 - 167
• Main Authors: Tang, Shiue-Cheng, Shen, Chia-Ning, Lin, Pei-Yu, Peng, Shih-Jung, Chien, Hung-Jen, Chou, Ya-Hsien, Chamberlain, Chester E., Pasricha, Pankaj J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2018; Springer Nature B.V
• Subjects: Adipose tissue; Animals; Body Weight - physiology; Ganglion Cysts - metabolism; Glucose; Histology; Human Physiology; Innervation; Insulin; Insulin - metabolism; Insulin secretion; Integration; Internal Medicine; Islets of Langerhans; Medicine; Medicine & Public Health; Metabolic Diseases; Mice; Nerve Net - metabolism; Neural networks; Obesity; Obesity - metabolism; Pancreas; Pancreas - metabolism; Rodents; Secretion; Weaning; Sympathetic nerve; Obesity; 3D histology; Islet; Neural network; Ganglion; Insulin

Aims/hypothesis It has been proposed that the neuro-insular network enables rapid, synchronised insulin secretion. However, to date, acquiring the pancreatic tissue map to study the neural network remains a challenging task as there is a lack of feasible approaches for large-scale tissue analysis at...