Liver Steatosis and Steatohepatitis Alter Bile Acid Receptors in Brain and Induce Neuroinflammation: A Contribution of Circulating Bile Acids and Blood-Brain Barrier

• Published in: International journal of molecular sciences Vol. 23; no. 22; p. 14254
• Main Authors: Fiaschini, Noemi, Mancuso, Mariateresa, Tanori, Mirella, Colantoni, Eleonora, Vitali, Roberta, Diretto, Gianfranco, Lorenzo Rebenaque, Laura, Stronati, Laura, Negroni, Anna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.11.2022; MDPI
• Subjects: Acids; Adaptor proteins; Animals; Bacteria; Bile; bile acid receptors; Bile acids; Bile Acids and Salts; Blood circulation; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Brain - metabolism; brain inflammation; Composition; Dextran; Dextrans; Diet; Down-regulation; Drinking behavior; Drinking water; Endothelial cells; Endothelial Cells - metabolism; Fatty liver; G protein-coupled receptors; High fat diet; Immunofluorescence; Immunohistochemistry; Inflammation; intestinal inflammation; Lipopolysaccharide-binding protein; Lipopolysaccharides; Liver; Liver diseases; Metabolism; Metabolites; Mice; Microbiota; Microglia; Nervous system; Neuroinflammatory Diseases; Non-alcoholic Fatty Liver Disease - metabolism; Occludin - metabolism; Permeability; Protein composition; Proteins; Steatosis; Zonula occludens-1 protein; blood brain barrier; brain inflammation; bile acids; liver; high-fat diet; intestinal inflammation; bile acid receptors

A tight relationship between gut-liver diseases and brain functions has recently emerged. Bile acid (BA) receptors, bacterial-derived molecules and the blood-brain barrier (BBB) play key roles in this association. This study was aimed to evaluate how non-alcoholic fatty liver disease (NAFLD) and non...