cAMP controls rod photoreceptor sensitivity via multiple targets in the phototransduction cascade
In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide-gated channels has shifted attention to cGMP as the only secon...
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Published in | The Journal of general physiology Vol. 140; no. 4; pp. 421 - 433 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Rockefeller University Press
01.10.2012
The Rockefeller University Press |
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Abstract | In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide-gated channels has shifted attention to cGMP as the only secondary messenger in the phototransduction cascade, and cAMP is not considered in modern schemes of phototransduction. Here, we report evidence that cAMP may also be involved in regulation of the phototransduction cascade. Using a suction pipette technique, we recorded light responses of isolated solitary rods from the frog retina in normal solution and in the medium containing 2 µM of adenylate cyclase activator forskolin. Under forskolin action, flash sensitivity rose more than twofold because of a retarded photoresponse turn-off. The same concentration of forskolin lead to a 2.5-fold increase in the rod outer segment cAMP, which is close to earlier reported natural day/night cAMP variations. Detailed analysis of cAMP action on the phototransduction cascade suggests that several targets are affected by cAMP increase: (a) basal dark phosphodiesterase (PDE) activity decreases; (b) at the same intensity of light background, steady background-induced PDE activity increases; (c) at light backgrounds, guanylate cyclase activity at a given fraction of open channels is reduced; and (d) the magnitude of the Ca(2+) exchanger current rises 1.6-fold, which would correspond to a 1.6-fold elevation of [Ca(2+)](in). Analysis by a complete model of rod phototransduction suggests that an increase of [Ca(2+)](in) might also explain effects (b) and (c). The mechanism(s) by which cAMP could regulate [Ca(2+)](in) and PDE basal activity is unclear. We suggest that these regulations may have adaptive significance and improve the performance of the visual system when it switches between day and night light conditions. |
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AbstractList | In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide–gated channels has shifted attention to cGMP as the only secondary messenger in the phototransduction cascade, and cAMP is not considered in modern schemes of phototransduction. Here, we report evidence that cAMP may also be involved in regulation of the phototransduction cascade. Using a suction pipette technique, we recorded light responses of isolated solitary rods from the frog retina in normal solution and in the medium containing 2 µM of adenylate cyclase activator forskolin. Under forskolin action, flash sensitivity rose more than twofold because of a retarded photoresponse turn-off. The same concentration of forskolin lead to a 2.5-fold increase in the rod outer segment cAMP, which is close to earlier reported natural day/night cAMP variations. Detailed analysis of cAMP action on the phototransduction cascade suggests that several targets are affected by cAMP increase: (a) basal dark phosphodiesterase (PDE) activity decreases; (b) at the same intensity of light background, steady background-induced PDE activity increases; (c) at light backgrounds, guanylate cyclase activity at a given fraction of open channels is reduced; and (d) the magnitude of the Ca2+ exchanger current rises 1.6-fold, which would correspond to a 1.6-fold elevation of [Ca2+]in. Analysis by a complete model of rod phototransduction suggests that an increase of [Ca2+]in might also explain effects (b) and (c). The mechanism(s) by which cAMP could regulate [Ca2+]in and PDE basal activity is unclear. We suggest that these regulations may have adaptive significance and improve the performance of the visual system when it switches between day and night light conditions. In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide-gated channels has shifted attention to cGMP as the only secondary messenger in the phototransduction cascade, and cAMP is not considered in modern schemes of phototransduction. Here, we report evidence that cAMP may also be involved in regulation of the phototransduction cascade. Using a suction pipette technique, we recorded light responses of isolated solitary rods from the frog retina in normal solution and in the medium containing 2 µM of adenylate cyclase activator forskolin. Under forskolin action, flash sensitivity rose more than twofold because of a retarded photoresponse turn-off. The same concentration of forskolin lead to a 2.5-fold increase in the rod outer segment cAMP, which is close to earlier reported natural day/night cAMP variations. Detailed analysis of cAMP action on the phototransduction cascade suggests that several targets are affected by cAMP increase: (a) basal dark phosphodiesterase (PDE) activity decreases; (b) at the same intensity of light background, steady background-induced PDE activity increases; (c) at light backgrounds, guanylate cyclase activity at a given fraction of open channels is reduced; and (d) the magnitude of the Ca(2+) exchanger current rises 1.6-fold, which would correspond to a 1.6-fold elevation of [Ca(2+)](in). Analysis by a complete model of rod phototransduction suggests that an increase of [Ca(2+)](in) might also explain effects (b) and (c). The mechanism(s) by which cAMP could regulate [Ca(2+)](in) and PDE basal activity is unclear. We suggest that these regulations may have adaptive significance and improve the performance of the visual system when it switches between day and night light conditions. In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide–gated channels has shifted attention to cGMP as the only secondary messenger in the phototransduction cascade, and cAMP is not considered in modern schemes of phototransduction. Here, we report evidence that cAMP may also be involved in regulation of the phototransduction cascade. Using a suction pipette technique, we recorded light responses of isolated solitary rods from the frog retina in normal solution and in the medium containing 2 µM of adenylate cyclase activator forskolin. Under forskolin action, flash sensitivity rose more than twofold because of a retarded photoresponse turn-off. The same concentration of forskolin lead to a 2.5-fold increase in the rod outer segment cAMP, which is close to earlier reported natural day/night cAMP variations. Detailed analysis of cAMP action on the phototransduction cascade suggests that several targets are affected by cAMP increase: (a) basal dark phosphodiesterase (PDE) activity decreases; (b) at the same intensity of light background, steady background-induced PDE activity increases; (c) at light backgrounds, guanylate cyclase activity at a given fraction of open channels is reduced; and (d) the magnitude of the Ca 2+ exchanger current rises 1.6-fold, which would correspond to a 1.6-fold elevation of [Ca 2+ ] in . Analysis by a complete model of rod phototransduction suggests that an increase of [Ca 2+ ] in might also explain effects (b) and (c). The mechanism(s) by which cAMP could regulate [Ca 2+ ] in and PDE basal activity is unclear. We suggest that these regulations may have adaptive significance and improve the performance of the visual system when it switches between day and night light conditions. In early studies, both cyclic AMP (cAMP) and cGMP were considered as potential secondary messengers regulating the conductivity of the vertebrate photoreceptor plasma membrane. Later discovery of the cGMP specificity of cyclic nucleotide-gated channels has shifted attention to cGMP as the only secondary messenger in the phototransduction cascade, and cAMP is not considered in modern schemes of phototransduction. Here, we report evidence that cAMP may also be involved in regulation of the phototransduction cascade. Using a suction pipette technique, we recorded light responses of isolated solitary rods from the frog retina in normal solution and in the medium containing 2 μM of adenylate cyclase activator forskolin. Under forskolin action, flash sensitivity rose more than twofold because of a retarded photoresponse turn-off. The same concentration of forskolin lead to a 2.5-fold increase in the rod outer segment cAMP, which is close to earlier reported natural day/night cAMP variations. Detailed analysis of cAMP action on the phototransduction cascade suggests that several targets are affected by cAMP increase: (a) basal dark phosphodiesterase (PDE) activity decreases; (b) at the same intensity of light background, steady background-induced PDE activity increases; (c) at light backgrounds, guanylate cyclase activity at a given fraction of open channels is reduced; and (d) the magnitude of the Ca2+ exchanger current rises 1.6-fold, which would correspond to a 1.6-fold elevation of [Ca2+]in. Analysis by a complete model of rod phototransduction suggests that an increase of [Ca2+]in might also explain effects (b) and (c). The mechanism(s) by which cAMP could regulate [Ca2+]in and PDE basal activity is unclear. We suggest that these regulations may have adaptive significance and improve the performance of the visual system when it switches between day and night light conditions. [PUBLICATION ABSTRACT] |
Author | Firsov, Michael L Astakhova, Luba A Govardovskii, Victor I Samoiliuk, Evgeniia V |
AuthorAffiliation | I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia |
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Author_xml | – sequence: 1 givenname: Luba A surname: Astakhova fullname: Astakhova, Luba A organization: IM Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia – sequence: 2 givenname: Evgeniia V surname: Samoiliuk fullname: Samoiliuk, Evgeniia V – sequence: 3 givenname: Victor I surname: Govardovskii fullname: Govardovskii, Victor I – sequence: 4 givenname: Michael L surname: Firsov fullname: Firsov, Michael L |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23008435$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1085/jgp.200810034 10.1111/j.1471-4159.2008.05691.x 10.1074/jbc.R111.305243 10.1111/j.1471-4159.2006.04154.x 10.1074/jbc.M111.230904 10.1111/j.1471-4159.2009.05920.x 10.1017/S0952523800176072 10.1038/334064a0 10.1021/bi960699e 10.1074/mcp.M700054-MCP200 10.1523/JNEUROSCI.15-10-06475.1995 10.1021/bi200491b 10.1167/iovs.06-0849 10.1074/jbc.M408683200 10.1146/annurev.neuro.24.1.779 10.1113/jphysiol.1989.sp017511 10.1113/jphysiol.1979.sp012715 10.1046/j.1471-4159.1999.0721812.x 10.1046/j.1460-9568.2000.00235.x 10.1021/bi973087i 10.1017/S0952523800006441 10.1016/j.brainres.2008.02.025 10.1111/j.1471-4159.1986.tb12921.x 10.1113/jphysiol.1992.sp019293 10.1073/pnas.70.12.3820 10.1073/pnas.68.3.561 10.1073/pnas.93.4.1475 10.1523/JNEUROSCI.22-06-02063.2002 10.1523/JNEUROSCI.0174-11.2011 10.1113/jphysiol.2006.121772 10.1016/S0896-6273(02)00636-0 10.1523/JNEUROSCI.2973-07.2008 10.1111/j.1471-4159.1989.tb07330.x 10.1523/JNEUROSCI.4988-03.2004 10.1074/jbc.M106328200 10.1007/BF00539174 10.1085/jgp.79.5.759 10.1016/S0006-3495(95)79917-9 10.1016/j.cell.2009.09.029 10.1016/S0006-3495(00)76443-5 10.1038/313310a0 10.1074/jbc.M505117200 10.1113/jphysiol.1988.sp017258 10.1085/jgp.79.5.775 10.1523/JNEUROSCI.3560-03.2004 10.1085/jgp.70.6.771 10.1074/jbc.M803875200 10.1113/jphysiol.1985.sp015561 10.1016/j.bbrc.2009.10.106 10.1016/j.brainres.2003.08.003 10.1002/bies.20777 |
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References | 1739680 - Vis Neurosci. 1992 Jan;8(1):9-18 112242 - J Physiol. 1979 Mar;288:589-611 2580087 - J Physiol. 1985 Jan;358:447-68 11896146 - J Neurosci. 2002 Mar 15;22(6):2063-73 19837030 - Cell. 2009 Oct 16;139(2):246-64 2470863 - J Neurochem. 1989 Jul;53(1):307-10 8780502 - Biochemistry. 1996 Aug 27;35(34):11013-8 19166506 - J Neurochem. 2009 Apr;109(1):148-57 2479741 - J Physiol. 1989 Feb;409:525-48 10217257 - J Neurochem. 1999 May;72(5):1812-20 6284859 - J Gen Physiol. 1982 May;79(5):759-74 18305241 - J Neurosci. 2008 Feb 27;28(9):2064-74 4359491 - Proc Natl Acad Sci U S A. 1973 Dec;70(12):3820-4 11023899 - Biophys J. 2000 Oct;79(4):1945-53 2455233 - Nature. 1988 Jul 7;334(6177):64-6 17122096 - Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5137-52 2473195 - J Physiol. 1988 Sep;403:439-71 201724 - J Gen Physiol. 1977 Dec;70(6):771-91 15448139 - J Biol Chem. 2004 Nov 26;279(48):50342-9 11029623 - Eur J Neurosci. 2000 Oct;12(10):3537-48 4322522 - Proc Natl Acad Sci U S A. 1971 Mar;68(3):561-2 18536031 - Bioessays. 2008 Jul;30(7):624-33 21504899 - J Biol Chem. 2011 Jun 10;286(23):20923-9 11741972 - J Biol Chem. 2002 Feb 15;277(7):5017-23 2415681 - J Neurochem. 1986 Jan;46(1):33-9 14960600 - J Neurosci. 2004 Feb 11;24(6):1296-304 8643657 - Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1475-9 18371938 - Brain Res. 2008 May 1;1207:111-9 18803695 - J Neurochem. 2008 Dec;107(5):1314-24 6284860 - J Gen Physiol. 1982 May;79(5):775-90 18955597 - J Gen Physiol. 2008 Nov;132(5):587-604 22074925 - J Biol Chem. 2012 Jan 13;287(3):1620-6 16981891 - J Neurochem. 2006 Nov;99(4):1142-50 21632928 - J Neurosci. 2011 Jun 1;31(22):8067-77 17494944 - Mol Cell Proteomics. 2007 Aug;6(8):1299-317 19878658 - Biochem Biophys Res Commun. 2009 Dec 25;390(4):1149-53 17138607 - J Physiol. 2007 Mar 1;579(Pt 2):303-12 11520918 - Annu Rev Neurosci. 2001;24:779-805 14985420 - J Neurosci. 2004 Feb 25;24(8):1803-11 11931744 - Neuron. 2002 Mar 28;34(1):95-106 6268219 - Biophys Struct Mech. 1981;7(3):125-30 11980887 - Invest Ophthalmol Vis Sci. 2002 May;43(5):1655-61 9558360 - Biochemistry. 1998 Apr 28;37(17):6205-13 11193104 - Vis Neurosci. 2000 Nov-Dec;17(6):887-92 15946941 - J Biol Chem. 2005 Aug 5;280(31):28241-50 8527658 - Biophys J. 1995 Aug;69(2):439-50 18687681 - J Biol Chem. 2008 Nov 14;283(46):31673-8 21598940 - Biochemistry. 2011 Jun 28;50(25):5590-600 2578616 - Nature. 1985 Jan 24-30;313(6000):310-3 7472410 - J Neurosci. 1995 Oct;15(10):6475-88 14575881 - Brain Res. 2003 Nov 21;991(1-2):96-103 1282928 - J Physiol. 1992 Sep;455:111-42 Fukuhara (2023072521395432100_bib11) 2004; 24 Baylor (2023072521395432100_bib3) 1979; 288 Burns (2023072521395432100_bib6) 2001; 24 Miki (2023072521395432100_bib32) 1973; 70 Hasegawa (2023072521395432100_bib13) 1999; 72 Sheng (2023072521395432100_bib44) 2000; 79 Willardson (2023072521395432100_bib50) 1996; 93 Ivanova (2023072521395432100_bib19) 2008; 1207 Paglia (2023072521395432100_bib38) 2002; 277 Pugh (2023072521395432100_bib43) 2000 Hodgkin (2023072521395432100_bib15) 1985; 358 Tsang (2023072521395432100_bib49) 2007; 579 Chaurasia (2023072521395432100_bib8) 2006; 99 Fesenko (2023072521395432100_bib10) 1985; 313 Besharse (2023072521395432100_bib4) 1982; 79 Ko (2023072521395432100_bib23) 2004; 24 Ivanova (2023072521395432100_bib18) 2003; 991 Li (2023072521395432100_bib29) 2008; 283 Traverso (2023072521395432100_bib48) 2002; 43 Wolbring (2023072521395432100_bib51) 1996; 35 Janisch (2023072521395432100_bib21) 2009; 390 Pagh-Roehl (2023072521395432100_bib37) 1995; 15 Koch (2023072521395432100_bib24) 1988; 334 Stella (2023072521395432100_bib46) 2000; 12 Woodruff (2023072521395432100_bib52) 2008; 28 Arshavsky (2023072521395432100_bib1) 2012; 287 Peshenko (2023072521395432100_bib41) 2011; 50 Yau (2023072521395432100_bib54) 2009; 139 Astakhova (2023072521395432100_bib2) 2008; 132 Jindrova (2023072521395432100_bib22) 2000; 17 Hodgkin (2023072521395432100_bib14) 1988; 403 Bitensky (2023072521395432100_bib5) 1971; 68 Iuvone (2023072521395432100_bib17) 1986; 46 Lagnado (2023072521395432100_bib27) 1992; 455 Kuzmin (2023072521395432100_bib26) 2004; 18 Pepperberg (2023072521395432100_bib39) 1992; 8 Nakatani (2023072521395432100_bib33) 1989; 409 Osawa (2023072521395432100_bib35) 2008; 107 Horner (2023072521395432100_bib16) 2005; 280 Pierce (2023072521395432100_bib42) 1989; 53 Lamb (2023072521395432100_bib28) 2006; 47 Tosini (2023072521395432100_bib47) 2008; 30 Kolesnikov (2023072521395432100_bib25) 2011; 31 Sokolov (2023072521395432100_bib45) 2002; 34 Liu (2023072521395432100_bib31) 2007; 6 Xu (2023072521395432100_bib53) 1998; 37 Govardovskii (2023072521395432100_bib12) 1981; 7 Burnside (2023072521395432100_bib7) 1982; 79 Peshenko (2023072521395432100_bib40) 2004; 279 Demontis (2023072521395432100_bib9) 1995; 69 Jackson (2023072521395432100_bib20) 2009; 109 Osawa (2023072521395432100_bib36) 2011; 286 Lipton (2023072521395432100_bib30) 1977; 70 Nir (2023072521395432100_bib34) 2002; 22 |
References_xml | – volume: 132 start-page: 587 year: 2008 ident: 2023072521395432100_bib2 article-title: Kinetics of turn-offs of frog rod phototransduction cascade publication-title: J. Gen. Physiol. doi: 10.1085/jgp.200810034 contributor: fullname: Astakhova – volume: 18 start-page: 305 year: 2004 ident: 2023072521395432100_bib26 article-title: Mathematical modeling of phototransduction and light adaptation in frog retinal rods publication-title: Sens. Syst. contributor: fullname: Kuzmin – volume: 107 start-page: 1314 year: 2008 ident: 2023072521395432100_bib35 article-title: Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2008.05691.x contributor: fullname: Osawa – volume: 43 start-page: 1655 year: 2002 ident: 2023072521395432100_bib48 article-title: Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Traverso – volume: 287 start-page: 1620 year: 2012 ident: 2023072521395432100_bib1 article-title: Photoreceptor signaling: supporting vision across a wide range of light intensities publication-title: J. Biol. Chem. doi: 10.1074/jbc.R111.305243 contributor: fullname: Arshavsky – volume: 99 start-page: 1142 year: 2006 ident: 2023072521395432100_bib8 article-title: Temporal coupling of cyclic AMP and Ca/calmodulin-stimulated adenylyl cyclase to the circadian clock in chick retinal photoreceptor cells publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2006.04154.x contributor: fullname: Chaurasia – volume: 286 start-page: 20923 year: 2011 ident: 2023072521395432100_bib36 article-title: Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.230904 contributor: fullname: Osawa – volume: 109 start-page: 148 year: 2009 ident: 2023072521395432100_bib20 article-title: Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2009.05920.x contributor: fullname: Jackson – volume: 17 start-page: 887 year: 2000 ident: 2023072521395432100_bib22 article-title: Cyclic AMP has no effect on the generation, recovery, or background adaptation of light responses in functionally intact rod outer segments: with implications about the function of phosducin publication-title: Vis. Neurosci. doi: 10.1017/S0952523800176072 contributor: fullname: Jindrova – volume: 334 start-page: 64 year: 1988 ident: 2023072521395432100_bib24 article-title: Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions publication-title: Nature. doi: 10.1038/334064a0 contributor: fullname: Koch – volume: 35 start-page: 11013 year: 1996 ident: 2023072521395432100_bib51 article-title: Modulation of the calcium sensitivity of bovine retinal rod outer segment guanylyl cyclase by sodium ions and protein kinase A publication-title: Biochemistry. doi: 10.1021/bi960699e contributor: fullname: Wolbring – volume: 6 start-page: 1299 year: 2007 ident: 2023072521395432100_bib31 article-title: The proteome of the mouse photoreceptor sensory cilium complex publication-title: Mol. Cell. Proteomics. doi: 10.1074/mcp.M700054-MCP200 contributor: fullname: Liu – volume: 15 start-page: 6475 year: 1995 ident: 2023072521395432100_bib37 article-title: Phosducin and PP33 are in vivo targets of PKA and type 1 or 2A phosphatases, regulators of cell elongation in teleost rod inner-outer segments publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.15-10-06475.1995 contributor: fullname: Pagh-Roehl – volume: 50 start-page: 5590 year: 2011 ident: 2023072521395432100_bib41 article-title: Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors publication-title: Biochemistry. doi: 10.1021/bi200491b contributor: fullname: Peshenko – volume: 47 start-page: 5137 year: 2006 ident: 2023072521395432100_bib28 article-title: Phototransduction, dark adaptation, and rhodopsin regeneration. The Proctor lecture publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-0849 contributor: fullname: Lamb – volume: 279 start-page: 50342 year: 2004 ident: 2023072521395432100_bib40 article-title: Ca2+-dependent conformational changes in guanylyl cyclase-activating protein 2 (GCAP-2) revealed by site-specific phosphorylation and partial proteolysis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M408683200 contributor: fullname: Peshenko – volume: 24 start-page: 779 year: 2001 ident: 2023072521395432100_bib6 article-title: Activation, deactivation, and adaptation in vertebrate photoreceptor cells publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.24.1.779 contributor: fullname: Burns – volume: 409 start-page: 525 year: 1989 ident: 2023072521395432100_bib33 article-title: Sodium-dependent calcium extrusion and sensitivity regulation in retinal cones of the salamander publication-title: J. Physiol. doi: 10.1113/jphysiol.1989.sp017511 contributor: fullname: Nakatani – volume: 288 start-page: 589 year: 1979 ident: 2023072521395432100_bib3 article-title: The membrane current of single rod outer segments publication-title: J. Physiol. doi: 10.1113/jphysiol.1979.sp012715 contributor: fullname: Baylor – volume: 72 start-page: 1812 year: 1999 ident: 2023072521395432100_bib13 article-title: A role for cyclic AMP in entrainment of the circadian oscillator in Xenopus retinal photoreceptors by dopamine but not by light publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1999.0721812.x contributor: fullname: Hasegawa – volume: 12 start-page: 3537 year: 2000 ident: 2023072521395432100_bib46 article-title: Differential modulation of rod and cone calcium currents in tiger salamander retina by D2 dopamine receptors and cAMP publication-title: Eur. J. Neurosci. doi: 10.1046/j.1460-9568.2000.00235.x contributor: fullname: Stella – volume: 37 start-page: 6205 year: 1998 ident: 2023072521395432100_bib53 article-title: Phosphorylation of the gamma subunit of the retinal photoreceptor cGMP phosphodiesterase by the cAMP-dependent protein kinase and its effect on the gamma subunit interaction with other proteins publication-title: Biochemistry. doi: 10.1021/bi973087i contributor: fullname: Xu – volume: 8 start-page: 9 year: 1992 ident: 2023072521395432100_bib39 article-title: Light-dependent delay in the falling phase of the retinal rod photoresponse publication-title: Vis. Neurosci. doi: 10.1017/S0952523800006441 contributor: fullname: Pepperberg – volume: 1207 start-page: 111 year: 2008 ident: 2023072521395432100_bib19 article-title: Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: relationship to dopamine receptor-mediated inhibition of cAMP formation publication-title: Brain Res. doi: 10.1016/j.brainres.2008.02.025 contributor: fullname: Ivanova – volume: 46 start-page: 33 year: 1986 ident: 2023072521395432100_bib17 article-title: Cyclic AMP stimulates serotonin N-acetyltransferase activity in Xenopus retina in vitro publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1986.tb12921.x contributor: fullname: Iuvone – volume: 455 start-page: 111 year: 1992 ident: 2023072521395432100_bib27 article-title: Calcium homeostasis in the outer segments of retinal rods from the tiger salamander publication-title: J. Physiol. doi: 10.1113/jphysiol.1992.sp019293 contributor: fullname: Lagnado – volume: 70 start-page: 3820 year: 1973 ident: 2023072521395432100_bib32 article-title: Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.70.12.3820 contributor: fullname: Miki – volume: 68 start-page: 561 year: 1971 ident: 2023072521395432100_bib5 article-title: Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.68.3.561 contributor: fullname: Bitensky – volume: 93 start-page: 1475 year: 1996 ident: 2023072521395432100_bib50 article-title: Regulation of phosducin phosphorylation in retinal rods by Ca2+/calmodulin-dependent adenylyl cyclase publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.93.4.1475 contributor: fullname: Willardson – volume: 22 start-page: 2063 year: 2002 ident: 2023072521395432100_bib34 article-title: Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-06-02063.2002 contributor: fullname: Nir – volume: 31 start-page: 8067 year: 2011 ident: 2023072521395432100_bib25 article-title: G-protein betagamma-complex is crucial for efficient signal amplification in vision publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0174-11.2011 contributor: fullname: Kolesnikov – volume: 579 start-page: 303 year: 2007 ident: 2023072521395432100_bib49 article-title: Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response publication-title: J. Physiol. doi: 10.1113/jphysiol.2006.121772 contributor: fullname: Tsang – volume: 34 start-page: 95 year: 2002 ident: 2023072521395432100_bib45 article-title: Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation publication-title: Neuron. doi: 10.1016/S0896-6273(02)00636-0 contributor: fullname: Sokolov – volume: 28 start-page: 2064 year: 2008 ident: 2023072521395432100_bib52 article-title: Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2973-07.2008 contributor: fullname: Woodruff – volume: 53 start-page: 307 year: 1989 ident: 2023072521395432100_bib42 article-title: Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1989.tb07330.x contributor: fullname: Pierce – volume: 24 start-page: 1803 year: 2004 ident: 2023072521395432100_bib11 article-title: Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4988-03.2004 contributor: fullname: Fukuhara – volume: 277 start-page: 5017 year: 2002 ident: 2023072521395432100_bib38 article-title: Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated publication-title: J. Biol. Chem. doi: 10.1074/jbc.M106328200 contributor: fullname: Paglia – volume: 7 start-page: 125 year: 1981 ident: 2023072521395432100_bib12 article-title: Light-induced changes of cyclic GMP content in frog retinal rod outer segments measured with rapid freezing and microdissection publication-title: Biophys. Struct. Mech. doi: 10.1007/BF00539174 contributor: fullname: Govardovskii – volume: 79 start-page: 759 year: 1982 ident: 2023072521395432100_bib7 article-title: Induction of dark-adaptive retinomotor movement (cell elongation) in teleost retinal cones by cyclic adenosine 3′,′5-monophosphate publication-title: J. Gen. Physiol. doi: 10.1085/jgp.79.5.759 contributor: fullname: Burnside – volume: 69 start-page: 439 year: 1995 ident: 2023072521395432100_bib9 article-title: Effect of blocking the Na+/K+ ATPase on Ca2+ extrusion and light adaptation in mammalian retinal rods publication-title: Biophys. J. doi: 10.1016/S0006-3495(95)79917-9 contributor: fullname: Demontis – start-page: 183 volume-title: Handbook of Biological Physics. year: 2000 ident: 2023072521395432100_bib43 article-title: Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification, recovery and light adaptation contributor: fullname: Pugh – volume: 139 start-page: 246 year: 2009 ident: 2023072521395432100_bib54 article-title: Phototransduction motifs and variations publication-title: Cell. doi: 10.1016/j.cell.2009.09.029 contributor: fullname: Yau – volume: 79 start-page: 1945 year: 2000 ident: 2023072521395432100_bib44 article-title: Na+-Ca2+-K+ currents measured in insect cells transfected with the retinal cone or rod Na+-Ca2+-K+ exchanger cDNA publication-title: Biophys. J. doi: 10.1016/S0006-3495(00)76443-5 contributor: fullname: Sheng – volume: 313 start-page: 310 year: 1985 ident: 2023072521395432100_bib10 article-title: Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment publication-title: Nature. doi: 10.1038/313310a0 contributor: fullname: Fesenko – volume: 280 start-page: 28241 year: 2005 ident: 2023072521395432100_bib16 article-title: Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities publication-title: J. Biol. Chem. doi: 10.1074/jbc.M505117200 contributor: fullname: Horner – volume: 403 start-page: 439 year: 1988 ident: 2023072521395432100_bib14 article-title: Control of light-sensitive current in salamander rods publication-title: J. Physiol. doi: 10.1113/jphysiol.1988.sp017258 contributor: fullname: Hodgkin – volume: 79 start-page: 775 year: 1982 ident: 2023072521395432100_bib4 article-title: Effects of cyclic adenosine 3′,5′-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation publication-title: J. Gen. Physiol. doi: 10.1085/jgp.79.5.775 contributor: fullname: Besharse – volume: 24 start-page: 1296 year: 2004 ident: 2023072521395432100_bib23 article-title: Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3560-03.2004 contributor: fullname: Ko – volume: 70 start-page: 771 year: 1977 ident: 2023072521395432100_bib30 article-title: Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins publication-title: J. Gen. Physiol. doi: 10.1085/jgp.70.6.771 contributor: fullname: Lipton – volume: 283 start-page: 31673 year: 2008 ident: 2023072521395432100_bib29 article-title: CLOCK is required for maintaining the circadian rhythms of Opsin mRNA expression in photoreceptor cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M803875200 contributor: fullname: Li – volume: 358 start-page: 447 year: 1985 ident: 2023072521395432100_bib15 article-title: The ionic selectivity and calcium dependence of the light-sensitive pathway in toad rods publication-title: J. Physiol. doi: 10.1113/jphysiol.1985.sp015561 contributor: fullname: Hodgkin – volume: 390 start-page: 1149 year: 2009 ident: 2023072521395432100_bib21 article-title: Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.10.106 contributor: fullname: Janisch – volume: 991 start-page: 96 year: 2003 ident: 2023072521395432100_bib18 article-title: Circadian rhythm and photic control of cAMP level in chick retinal cell cultures: a mechanism for coupling the circadian oscillator to the melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase, in photoreceptor cells publication-title: Brain Res. doi: 10.1016/j.brainres.2003.08.003 contributor: fullname: Ivanova – volume: 30 start-page: 624 year: 2008 ident: 2023072521395432100_bib47 article-title: The circadian clock system in the mammalian retina publication-title: Bioessays. doi: 10.1002/bies.20777 contributor: fullname: Tosini |
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SubjectTerms | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Adenylyl Cyclases - drug effects Animals Calcium Calcium - metabolism Colforsin - pharmacology Cyclic AMP - agonists Cyclic AMP - metabolism Guanylate Cyclase - metabolism Light Light Signal Transduction Membranes Molecules Physiology Rana ridibunda Rod Cell Outer Segment - metabolism Rod Cell Outer Segment - physiology Signal transduction Vertebrates Vision, Ocular |
Title | cAMP controls rod photoreceptor sensitivity via multiple targets in the phototransduction cascade |
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