Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans - Caskey, Marina; Lefebvre, François; Filali-Mouhim, Abdelali; Cameron, Mark J.; Goulet, Jean-Philippe; Haddad, Elias K.; Breton, Gaëlle; Trumpfheller, Christine; Pollak, Sarah; Shimeliovich, Irina; Duque-Alarcon, Angela; Pan, Li; et al. (The Journal of experimental medicine, 2011)
Keywords: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - pharmacology; Brief Definitive Report; Carboxymethylcellulose Sodium - administration & dosage; Carboxymethylcellulose Sodium - analogs & derivatives; Carboxymethylcellulose Sodium - pharmacology; Cytokines - metabolism; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Humans; Immunity, Innate - drug effects; Inflammasomes - metabolism; Injections, Subcutaneous; Interferons - metabolism; Microarray Analysis; Poly I-C - administration & dosage; Poly I-C - immunology; Poly I-C - pharmacology; Polylysine - administration & dosage; Polylysine - analogs & derivatives; Polylysine - immunology; Polylysine - pharmacology; Real-Time Polymerase Chain Reaction; Signal Transduction - drug effects; Signal Transduction - immunology; Viral Vaccines - immunology