Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms - Mancino, Adamo S.; Glass, William G.; Yan, Yuhao; Biggin, Philip C.; Bowie, Derek (The Journal of general physiology, 2022)
Keywords: Adult; Alternative splicing; Amino acids; Biophysics; Cellular Physiology; Channel gating; Computational Biology; Electrophysiological Phenomena; Electrostatic properties; Heart; Humans; Infant, Newborn; Isoforms; Molecular Dynamics Simulation; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Neonates; Protein Isoforms - genetics; Protein Isoforms - metabolism; Skeletal muscle; Sodium channels (voltage-gated); Voltage-Gated Sodium Channels - metabolism