The Neurobiology of the Meibomian Glands

Abstract This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian gland morphology and regulation via hormones, a case for innervation is made based on anatomical findings whereby the nerves lack a myelin sheath...

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Published inThe ocular surface Vol. 12; no. 3; pp. 167 - 177
Main Authors Cox, Stephanie M., OD, Nichols, Jason J., OD, MPH, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2014
Subjects
Animals
calcitonin gene-related peptide
dopamine beta-hydroxylase
Humans
innervations
meibomian gland
Meibomian Glands - blood supply
Meibomian Glands - innervation
Meibomian Glands - metabolism
neuroanatomy
Neurobiology - methods
neuropeptide Y
Neuropeptides - metabolism
Ophthalmology
substance P
tyrosine hydroxylase
vasoactive intestinal polypeptide
innervations
neuropeptide Y
calcitonin gene-related peptide
dopamine beta-hydroxylase
neuroanatomy
substance P
meibomian gland
vasoactive intestinal polypeptide
tyrosine hydroxylase
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Abstract Abstract This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian gland morphology and regulation via hormones, a case for innervation is made based on anatomical findings whereby the nerves lack a myelin sheath and Schwann cells. The localization and co-localization of dopamine beta-hydroxylase, tyrosine hydroxylase, neuropeptide Y, vasoactive intestinal polypeptide, calcitonin gene-related peptide, and substance P are explored with emphasis on differences that exist between species. The presence of the various neuropeptides/neurotransmitters adjacent to the meibomian gland versus the vasculature associated with the meibomian gland is documented so that conclusions can be made with regard to direct and indirect effects. Research regarding the presence of receptors and receptor proteins for these neuropeptides is documented. Evidence supporting the influence of certain neurotransmitters and/or neuropeptides on the meibomian gland is given based on research that correlates changes in meibomian gland morphology and/or tear film with changes in neurotransmitter and/or neuropeptide presence. Conclusions are drawn related to direct and indirect regulation and differences between the various nervous systems.
AbstractList This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian gland morphology and regulation via hormones, a case for innervation is made based on anatomical findings whereby the nerves lack a myelin sheath and Schwann cells. The localization and co-localization of dopamine beta-hydroxylase, tyrosine hydroxylase, neuropeptide Y, vasoactive intestinal polypeptide, calcitonin gene-related peptide, and substance P are explored with emphasis on differences that exist between species. The presence of the various neuropeptides/neurotransmitters adjacent to the meibomian gland versus the vasculature associated with the meibomian gland is documented so that conclusions can be made with regard to direct and indirect effects. Research regarding the presence of receptors and receptor proteins for these neuropeptides is documented. Evidence supporting the influence of certain neurotransmitters and/or neuropeptides on the meibomian gland is given based on research that correlates changes in meibomian gland morphology and/or tear film with changes in neurotransmitter and/or neuropeptide presence. Conclusions are drawn related to direct and indirect regulation and differences between the various nervous systems.
Abstract This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian gland morphology and regulation via hormones, a case for innervation is made based on anatomical findings whereby the nerves lack a myelin sheath and Schwann cells. The localization and co-localization of dopamine beta-hydroxylase, tyrosine hydroxylase, neuropeptide Y, vasoactive intestinal polypeptide, calcitonin gene-related peptide, and substance P are explored with emphasis on differences that exist between species. The presence of the various neuropeptides/neurotransmitters adjacent to the meibomian gland versus the vasculature associated with the meibomian gland is documented so that conclusions can be made with regard to direct and indirect effects. Research regarding the presence of receptors and receptor proteins for these neuropeptides is documented. Evidence supporting the influence of certain neurotransmitters and/or neuropeptides on the meibomian gland is given based on research that correlates changes in meibomian gland morphology and/or tear film with changes in neurotransmitter and/or neuropeptide presence. Conclusions are drawn related to direct and indirect regulation and differences between the various nervous systems.
Author Nichols, Jason J., OD, MPH, PhD
Cox, Stephanie M., OD
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Issue 3
Keywords innervations
neuropeptide Y
calcitonin gene-related peptide
dopamine beta-hydroxylase
neuroanatomy
substance P
meibomian gland
vasoactive intestinal polypeptide
tyrosine hydroxylase
Language English
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SecondaryResourceType review_article
Snippet Abstract This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian...
This article compiles research regarding the neuroanatomy of the meibomian glands and their associated blood vessels. After a review of meibomian gland...
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elsevier
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SubjectTerms Animals
calcitonin gene-related peptide
dopamine beta-hydroxylase
Humans
innervations
meibomian gland
Meibomian Glands - blood supply
Meibomian Glands - innervation
Meibomian Glands - metabolism
neuroanatomy
Neurobiology - methods
neuropeptide Y
Neuropeptides - metabolism
Ophthalmology
substance P
tyrosine hydroxylase
vasoactive intestinal polypeptide
Title The Neurobiology of the Meibomian Glands
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1542012414000755
https://dx.doi.org/10.1016/j.jtos.2014.01.005
https://www.ncbi.nlm.nih.gov/pubmed/24999100
https://search.proquest.com/docview/1553710491
Volume 12
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