Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 11; p. 3109
• Main Authors: Moin, Abu Saleh Md, Nandakumar, Manjula, Kahal, Hassan, Sathyapalan, Thozhukat, Atkin, Stephen L., Butler, Alexandra E.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.11.2021; MDPI
• Subjects: Adult; Aptamers; Biomarkers - metabolism; Case-Control Studies; Chemokines; CXCL10 protein; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetic neuropathy; Diabetic retinopathy; Dinoprost - analogs & derivatives; Dinoprost - metabolism; Enzymes; Female; Glucose; Heat shock proteins; Heat-Shock Proteins - blood; Heat-Shock Response; Humans; Hypoglycemia; Hypoglycemia - blood; Hypoglycemia - metabolism; Inflammation; Inflammation - metabolism; inflammatory proteins; Interleukin 5; Kinases; Ligands; Male; Middle Aged; Oxidative Stress; Protein Interaction Mapping; Proteins - metabolism; Software; Statistical analysis; TLR4 protein; Toll-like receptors; type 2 diabetes; Ubiquitin-Conjugating Enzymes - metabolism; United Kingdom > UK; United States > US; Switzerland; inflammatory proteins; type 2 diabetes; heat shock proteins; oxidative stress; hypoglycemia
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells10113109

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elicits a similar response with inflammatory and oxidative-stress responses compared with a severe hypoglycemic event is unclear...