Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1–p38–Xanthine Oxidoreductase–Dependent Cigarette Smoke–Induced Apoptosis

• Published in: American journal of respiratory cell and molecular biology Vol. 54; no. 4; pp. 504 - 514
• Main Authors: Fallica, Jonathan, Varela, Lidenys, Johnston, Laura, Kim, Bo, Serebreni, Leonid, Wang, Lan, Damarla, Mahendra, Kolb, Todd M., Hassoun, Paul M., Damico, Rachel
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.04.2016
• Subjects: Animals; Apoptosis; Cells, Cultured; Chronic obstructive pulmonary disease; Cytotoxicity; Deoxyribonucleic acid; DNA; Emphysema; Enzyme Activation; Enzymes; Human subjects; Humans; Kinases; Lungs; Macrophage Migration-Inhibitory Factors - genetics; Macrophage Migration-Inhibitory Factors - physiology; MAP Kinase Kinase Kinase 5 - metabolism; Mice; Mice, Inbred C57BL; Nicotiana; Original Research; Oxidative stress; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Proteins; Rats; Reactive Oxygen Species - metabolism; Rodents; Smoke; Xanthine Dehydrogenase - metabolism; apoptosis; cigarette; migration inhibitory factor; apoptosis signal–regulating kinase 1; xanthine oxidase

Cigarette smoke (CS) exposure is the leading cause of emphysema. CS mediates pathologic emphysematous remodeling of the lung via apoptosis of lung parenchymal cells resulting in enlargement of the airspaces, loss of the capillary bed, and diminished surface area for gas exchange. Macrophage migratio...