Molecular Markers in Urinary Bladder Cancer: Applications for Diagnosis, Prognosis and Therapy

Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack...

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Published inVeterinary sciences Vol. 9; no. 3; p. 107
Main Authors Rasteiro, Ana Mafalda, Sá E Lemos, Eva, Oliveira, Paula A, Gil da Costa, Rui M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.02.2022
MDPI
Subjects
Biomarkers
Bladder cancer
Cancer
Cattle
Cellular biology
Diagnosis
Diagnostic tests
Domestic animals
Etiology
Hematuria
histology
Laboratory animals
Medical prognosis
Metastasis
Pathogenesis
Prognosis
Review
therapeutic marker
transitional cell carcinoma
Tumors
Urinary bladder
Urine
Urogenital system
urothelial carcinoma
Veterinary medicine
urothelial carcinoma
therapeutic marker
histology
prognosis
transitional cell carcinoma
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Abstract Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.
AbstractList Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological BRAF mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.
Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological BRAF mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.
Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.
Author Oliveira, Paula A
Rasteiro, Ana Mafalda
Sá E Lemos, Eva
Gil da Costa, Rui M
AuthorAffiliation 3 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal; pamo@utad.pt
1 CEDIVET, Laboratório Clínico Veterinário, 4200-071 Porto, Portugal; ana.rasteiro@gardenvets.co.uk (A.M.R.); evasalemos@gmail.com (E.S.e.L.)
5 Postgraduate Programme in Adult Health (PPGSAD), Department of Morphology, University Hospital (HUUFMA), Federal University of Maranhão (UFMA), São Luís 65080-805, Brazil
2 Garden Veterinary Group, Chippenham SN15 1NQ, UK
6 LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
4 Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), 4200-072 Porto, Po
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– name: 2 Garden Veterinary Group, Chippenham SN15 1NQ, UK
– name: 5 Postgraduate Programme in Adult Health (PPGSAD), Department of Morphology, University Hospital (HUUFMA), Federal University of Maranhão (UFMA), São Luís 65080-805, Brazil
– name: 3 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal; pamo@utad.pt
– name: 4 Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), 4200-072 Porto, Portugal
Author_xml – sequence: 1
  givenname: Ana Mafalda
  surname: Rasteiro
  fullname: Rasteiro, Ana Mafalda
  organization: Garden Veterinary Group, Chippenham SN15 1NQ, UK
– sequence: 2
  givenname: Eva
  surname: Sá E Lemos
  fullname: Sá E Lemos, Eva
  organization: CEDIVET, Laboratório Clínico Veterinário, 4200-071 Porto, Portugal
– sequence: 3
  givenname: Paula A
  orcidid: 0000-0001-9519-4044
  surname: Oliveira
  fullname: Oliveira, Paula A
  organization: Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal
– sequence: 4
  givenname: Rui M
  orcidid: 0000-0002-2151-2449
  surname: Gil da Costa
  fullname: Gil da Costa, Rui M
  email: RISE@CI-IPOP
  organization: LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35324835$$D View this record in MEDLINE/PubMed
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Keywords urothelial carcinoma
therapeutic marker
histology
prognosis
transitional cell carcinoma
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Snippet Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species...
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SubjectTerms Biomarkers
Bladder cancer
Cancer
Cattle
Cellular biology
Diagnosis
Diagnostic tests
Domestic animals
Etiology
Hematuria
histology
Laboratory animals
Medical prognosis
Metastasis
Pathogenesis
Prognosis
Review
therapeutic marker
transitional cell carcinoma
Tumors
Urinary bladder
Urine
Urogenital system
urothelial carcinoma
Veterinary medicine
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Title Molecular Markers in Urinary Bladder Cancer: Applications for Diagnosis, Prognosis and Therapy
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