Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 11; p. 3066
• Main Authors: Farhan, Fahad, Almarhoun, Mohammad, Wong, Aileen, Findlay, Amy S, Bartholomew, Chris, Williams, Mark T S, Hurd, Toby W, Shu, Xinhua
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.11.2021; MDPI
• Subjects: ABCA1 protein; Age; age-related macular degeneration; Aging; Animals; ATP-binding protein; Binding sites; Biological Transport; Cholesterol; Cholesterol - metabolism; Choroid - metabolism; Cytokines; Cytokines - metabolism; Ethanol; Gene Deletion; Gene expression; Gene Expression Regulation; Homeostasis; Homeostasis - genetics; Inflammation; Inflammation - genetics; Inflammation Mediators - metabolism; Ligands; Light microscopy; Lipid Metabolism; Lipids; Macular degeneration; Membrane proteins; Metabolism; Mice; Mice, Knockout; Microglia - metabolism; Microglia - pathology; Mitochondria; Phospholipids; Polymerase chain reaction; Protein transport; Proteins; Receptors, GABA - genetics; Receptors, GABA - metabolism; Retina; Retina - metabolism; Retina - pathology; Retinal Pigment Epithelium - metabolism; Steroids; Triglycerides; TSPO; United Kingdom > UK; TSPO; cholesterol; inflammation; retina; age-related macular degeneration

Cholesterol dysregulation has been implicated in age-related macular degeneration (AMD), the most common cause of visual impairment in the elderly. The 18 KDa translocator protein (TSPO) is a mitochondrial outer membrane protein responsible for transporting cholesterol from the mitochondrial outer m...