Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)

• Published in: Biochemical journal Vol. 373; no. Pt 1; pp. 49 - 55
• Main Authors: Riefler, Gary M, Balasingam, Gaithri, Lucas, Kenyatta G, Wang, Sheng, Hsu, Shu-Chan, Firestein, Bonnie L
• Format: Journal Article
• Language: English
• Published: England 01.07.2003
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Brain - metabolism; Carrier Proteins - chemistry; Carrier Proteins - isolation & purification; Carrier Proteins - metabolism; Cloning, Molecular; Disks Large Homolog 4 Protein; DNA Primers; Escherichia coli - genetics; Guanine Deaminase; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Molecular Sequence Data; Nerve Tissue Proteins - chemistry; Nerve Tissue Proteins - isolation & purification; Nerve Tissue Proteins - metabolism; Neurites - physiology; PC12 Cells; Polymerase Chain Reaction; Protein Subunits - metabolism; Rats; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - isolation & purification; Recombinant Fusion Proteins - metabolism; Vesicular Transport Proteins

The PDZ domains of postsynaptic density (PSD) protein-95 play a role in the localization of PSD-95 and binding partners to neuronal synapses. The identification of binding partners to these PDZ domains can help us in understanding how signalling complexes are assembled. We observed that one of the s...