Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System

• Published in: The Journal of heart and lung transplantation Vol. 36; no. 11; pp. 1192 - 1200
• Main Authors: Halloran, Philip F., Potena, Luciano, Van Huyen, Jean-Paul Duong, Bruneval, Patrick, Leone, Ornella, Kim, Daniel H., Jouven, Xavier, Reeve, Jeff, Loupy, Alexandre
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Antibodies - immunology; antibody-mediated rejection; archetype analysis; Biopsy; endomyocardial biopsy; Graft Rejection - diagnosis; Graft Rejection - immunology; Graft Rejection - metabolism; Heart Transplantation; Humans; microarrays; Molecular Diagnostic Techniques - instrumentation; Myocardium - metabolism; Myocardium - pathology; Pathology, Molecular - methods; Prognosis; Prospective Studies; rejection-associated transcripts; T cell–mediated rejection; T-Lymphocytes - immunology; endomyocardial biopsy; T cell–mediated rejection; rejection-associated transcripts; archetype analysis; antibody-mediated rejection; microarrays

The emergence of molecular systems offers opportunities for improving the assessment of rejection in heart transplant biopsy specimens. The present study developed a microarray-based system for assessing heart transplant endomyocardial biopsy (EMB) specimens. We analyzed 331 protocol or for-cause EM...