Semantic Knowledge in Mild Cognitive Impairment and Mild Alzheimer's Disease

The aim of this study was to investigate memory in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Ten patients with MCI, 11 with AD and a group of age and education matched healthy control participants were assessed on a comprehensive battery of semantic memory...

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Published inCortex Vol. 42; no. 5; pp. 675 - 684
Main Authors Adlam, Anna-Lynne R., Bozeat, Sasha, Arnold, Robert, Watson, Peter, Hodges, John R.
Format Journal Article
LanguageEnglish
Published Italy Elsevier Srl 2006
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Abstract The aim of this study was to investigate memory in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Ten patients with MCI, 11 with AD and a group of age and education matched healthy control participants were assessed on a comprehensive battery of semantic memory tests, including traditional semantic memory measures and a non-verbal test of knowledge of object use. The MCI group was impaired on tests of category fluency and all three conditions of an object knowledge test (matching to recipient, function and action), plus a difficult object-naming test. The mild AD group showed additional impairments on traditional measures of semantic memory, including naming high frequency items, comprehension and semantic association. Together these findings suggest that semantic memory impairments occur early in the course of AD, more specifically in patients with “amnesic” MCI, and provide further evidence that impaired category fluency reflects semantic breakdown.
AbstractList The aim of this study was to investigate memory in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Ten patients with MCI, 11 with AD and a group of age and education matched healthy control participants were assessed on a comprehensive battery of semantic memory tests, including traditional semantic memory measures and a non-verbal test of knowledge of object use. The MCI group was impaired on tests of category fluency and all three conditions of an object knowledge test (matching to recipient, function and action), plus a difficult object-naming test. The mild AD group showed additional impairments on traditional measures of semantic memory, including naming high frequency items, comprehension and semantic association. Together these findings suggest that semantic memory impairments occur early in the course of AD, more specifically in patients with “amnesic” MCI, and provide further evidence that impaired category fluency reflects semantic breakdown.
Author Arnold, Robert
Hodges, John R.
Adlam, Anna-Lynne R.
Bozeat, Sasha
Watson, Peter
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– sequence: 2
  givenname: Sasha
  surname: Bozeat
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  organization: Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, UK
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  organization: Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, UK
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  givenname: John R.
  surname: Hodges
  fullname: Hodges, John R.
  organization: Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16909626$$D View this record in MEDLINE/PubMed
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Snippet The aim of this study was to investigate memory in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Ten patients with MCI, 11...
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SubjectTerms Adult
Aged
Aged, 80 and over
Alzheimer Disease - psychology
Alzheimer's disease
Cognition Disorders - psychology
Female
Humans
Knowledge
Male
Memory - physiology
Middle Aged
mild cognitive impairment
Neuropsychological Tests
Psycholinguistics
Psychomotor Performance - physiology
semantic memory
Semantics
Title Semantic Knowledge in Mild Cognitive Impairment and Mild Alzheimer's Disease
URI https://dx.doi.org/10.1016/S0010-9452(08)70404-0
https://www.ncbi.nlm.nih.gov/pubmed/16909626
https://search.proquest.com/docview/68744490
Volume 42
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