In vivo affinity and target engagement in skin and blood in a first‐time‐in‐human study of an anti‐oncostatin M monoclonal antibody - Reid, Juliet; Zamuner, Stefano; Edwards, Ken; Rumley, Sally‐Anne; Nevin, Katherine; Feeney, Maria; Zecchin, Chiara; Fernando, Disala; Wisniacki, Nicolas (British journal of clinical pharmacology, 2018)
Keywords: Adult; affinity; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - pharmacokinetics; Area Under Curve; Blister - drug therapy; Blister - etiology; Blister - immunology; Blister - pathology; Double-Blind Method; Female; first‐time‐in‐human; GSK2330811; Healthy Volunteers; Humans; Injections, Subcutaneous; Male; Middle Aged; Models, Biological; oncostatin M; Oncostatin M - antagonists & inhibitors; Oncostatin M - immunology; Original; Placebos - administration & dosage; Placebos - adverse effects; Skin - drug effects; Skin - immunology; Skin - pathology; Suction - adverse effects; target engagement; GSK2330811; oncostatin M; target engagement; first-time-in-human; affinity