Effect of oral vitamin E (α-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus

• Published in: Diabetic medicine Vol. 16; no. 4; pp. 304 - 311
• Main Authors: Gazis, A., White, D. J., Page, S. R., Cockcroft, J. R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.04.1999; Blackwell
• Subjects: acetylcholine; Administration, Oral; Associated diseases and complications; Biological and medical sciences; bradykinin; Case-Control Studies; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Dietary Supplements; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; endothelium; Endothelium, Vascular - physiopathology; Female; Forearm - blood supply; Humans; Male; Medical sciences; Middle Aged; Regional Blood Flow - drug effects; tocopherol; Type 2 diabetes mellitus; Vitamin E - therapeutic use; Endocrinopathy; Human; Cardiovascular disease; α-Tocopherol; Acetylcholine; Supplementation; E-Vitamins; Antioxidant; Non insulin dependent diabetes; Endothelium

Summary Aims Vascular endothelial dysfunction, an early marker of atherosclerosis, has been demonstrated in Type 2 diabetes mellitus (DM). Vitamin E preserves endothelial function in animal models of diabetes and reduces cardiovascular risk. We examined endothelial function and the effect of vitamin...