Higher Mitochondrial Respiration and Uncoupling with Reduced Electron Transport Chain Content in Vivo in Muscle of Sedentary Versus Active Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 1; pp. 129 - 136
• Main Authors: Conley, Kevin E., Amara, Catherine E., Bajpeyi, Sudip, Costford, Sheila R., Murray, Kori, Jubrias, Sharon A., Arakaki, Lori, Marcinek, David J., Smith, Steven R.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2013; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Accelerometry - methods; Adult; Biological and medical sciences; Biopsy; Cell Respiration; Electron Transport - physiology; Electron transport chain; Electron Transport Chain Complex Proteins - metabolism; Electron Transport Chain Complex Proteins - physiology; Endocrine Care; Endocrinopathies; Energy Metabolism - physiology; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Humans; Male; Medical sciences; Metabolic rate; Metabolism; Mitochondria; Mitochondria, Muscle - metabolism; Motor Activity - physiology; Muscle, Skeletal - metabolism; Oxygen Consumption - physiology; Physical activity; Protein transport; Respiration; Rest; Sedentary Lifestyle; Spectroscopy; Surveys and Questionnaires; Up-Regulation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Young Adult; Human; Obesity; Nutrition; Nutrition disorder; Metabolic diseases; In vivo; Mitochondria; Reduction; Content; Muscle; Respiration; Sedentary; Transport; Endocrinology; Nutritional status; Comparative study

Objective:This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active individuals.Research Design and Methods:Chronic activity level was characterized by a physical activity questionnaire and a triaxial accelerometer as wel...