Emerging Role of Epigenetic Mechanisms in Alcohol Addiction

• Published in: Alcoholism, clinical and experimental research Vol. 41; no. 4; pp. 666 - 680
• Main Authors: Berkel, Tiffani D.M., Pandey, Subhash C.
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Alcoholism; Alcoholism - diagnosis; Alcoholism - genetics; Alcoholism - metabolism; Amygdala; Animals; Anxiety; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; DNA Methylation; DNA Methylation - physiology; Epigenesis, Genetic - physiology; Epigenetics; Histone Acetylation; Histone Acetyltransferases - genetics; Histone Acetyltransferases - metabolism; Histone Methylation; Humans; DNA Methylation; Histone Methylation; Amygdala; Alcoholism; Epigenetics; Anxiety; Histone Acetylation

Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent behavioral and neurochemical manifestations. Both genetic and environmental factors are known to contribute to the development of AUD, and recent studies on alcohol exposure and subsequent changes in gene expression s...