Synthesis of Cytotoxic Palmerolides

• Published in: Chemistry : a European journal Vol. 19; no. 48; pp. 16146 - 16168
• Main Authors: Lisboa, Marilda P., Dudley, Gregory B.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 25.11.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Antarctic Regions; Antarctica; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological; Biological Products - chemical synthesis; Biological Products - chemistry; Biological Products - pharmacology; Cellular; Chemistry; Chemotherapy; Cytotoxicity; fragment assembly; Humans; Macrolides - chemical synthesis; Macrolides - chemistry; Macrolides - pharmacology; Marine Biology; marine natural products; Melanoma; natural product synthesis; palmerolide; Strategy; Surgical implants; Synthesis; Synthesis (chemistry); Antarctic Regions; melanoma; palmerolide; marine natural products; fragment assembly; natural product synthesis

The chemical synthesis of the palmerolides is the subject of this review. The palmerolides are a family of Antarctic marine natural products, many of which display potent and selective cytotoxicity against melanoma cells. The confluence of promising bioactivities, limited natural supplies, and compl...