Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs

• Published in: Allergy (Copenhagen) Vol. 68; no. 8; pp. 1001 - 1007
• Main Authors: Campo, P., Ayuso, P., Salas, M., Plaza, M. C., Cornejo‐García, J. A., Doña, I., Torres, M. J., Blanca‐López, N., Canto, G., Guéant, J.‐L., Sanak, M., Blanca, M.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.08.2013; Wiley
• Subjects: Administration, Intranasal; Adolescent; Adult; Aged; Allergies; Angioedema - chemically induced; Angioedema - genetics; Angioedema - immunology; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Aspirin - administration & dosage; Aspirin - adverse effects; aspirin‐exacerbated cutaneous disease; Female; Genotype & phenotype; Humans; Immunophenotyping - methods; Inflammation Mediators - metabolism; inflammatory mediators; Life Sciences; lysine nasal challenge; Male; Middle Aged; multiple nonsteroidal anti‐inflammatory drug‐induced urticaria/angioedema; Nonsteroidal anti-inflammatory drugs; Respiratory Hypersensitivity - chemically induced; Respiratory Hypersensitivity - genetics; Respiratory Hypersensitivity - immunology; Urticaria - chemically induced; Urticaria - genetics; Urticaria - immunology; Young Adult; inflammatory mediators; nonsteroidal anti-inflammatory drugs; aspirin-exacerbated cutaneous disease; lysine nasal challenge; multiple nonsteroidal anti-inflammatory drug-induced urticaria/angioedema

Background Multiple NSAID‐induced urticaria/angioedema (MNSAID‐UA) is an entity well differentiated from aspirin‐exacerbated respiratory disease (AERD), although no detailed phenotype analysis has yet been performed. The objective was to evaluate the functional characteristics of MNSAID‐UA subjects...