The association of indoxyl sulfate with fibroblast growth factor‐23 in cats with chronic kidney disease

• Published in: Journal of veterinary internal medicine Vol. 33; no. 2; pp. 686 - 693
• Main Authors: Liao, Yu‐Lun, Chou, Chi‐Chung, Lee, Ya‐Jane
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2019
• Subjects: Animals; azotemia; Biochemistry; blood serum; Case-Control Studies; Cat Diseases - blood; Cats; Chromatography; Chromatography, High Pressure Liquid - veterinary; creatinine; Disease Progression; enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - veterinary; feline renal diseases; Female; fibroblast growth factors; Fibroblast Growth Factors - blood; Fibroblasts; Growth factors; high performance liquid chromatography; Indican - blood; Kidney diseases; Laboratory animals; Male; Medical prognosis; Metabolism; phosphate regulator; phosphates; progression; Proteins; renal function; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - veterinary; Retrospective Studies; secretion; Severity of Illness Index; SMALL ANIMAL; Studies; sulfates; uremic toxin; Urinalysis; Urine; Japan; azotemia; progression; uremic toxin; phosphate regulator; feline renal diseases

Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whe...