The association of indoxyl sulfate with fibroblast growth factor‐23 in cats with chronic kidney disease

Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whe...

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Published inJournal of veterinary internal medicine Vol. 33; no. 2; pp. 686 - 693
Main Authors Liao, Yu‐Lun, Chou, Chi‐Chung, Lee, Ya‐Jane
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.03.2019
Subjects
Animals
azotemia
Biochemistry
blood serum
Case-Control Studies
Cat Diseases - blood
Cats
Chromatography
Chromatography, High Pressure Liquid - veterinary
creatinine
Disease Progression
enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
feline renal diseases
Female
fibroblast growth factors
Fibroblast Growth Factors - blood
Fibroblasts
Growth factors
high performance liquid chromatography
Indican - blood
Kidney diseases
Laboratory animals
Male
Medical prognosis
Metabolism
phosphate regulator
phosphates
progression
Proteins
renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - veterinary
Retrospective Studies
secretion
Severity of Illness Index
SMALL ANIMAL
Studies
sulfates
uremic toxin
Urinalysis
Urine
Japan
azotemia
progression
uremic toxin
phosphate regulator
feline renal diseases
Online AccessGet full text

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Abstract Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD. Hypothesis Accumulation of IS is related to FGF‐23 secretion in cats with CKD. Animals Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. Methods The concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. Results Plasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF‐23 predicted renal progression at a level >0.9. Conclusions and Clinical Importance Both FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
AbstractList Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD. Hypothesis Accumulation of IS is related to FGF‐23 secretion in cats with CKD. Animals Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. Methods The concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. Results Plasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF‐23 predicted renal progression at a level >0.9. Conclusions and Clinical Importance Both FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD. Accumulation of IS is related to FGF-23 secretion in cats with CKD. Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. The concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. Plasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9. Both FGF-23 and IS are associated with phosphate metabolism and CKD progression.
BACKGROUND: Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD. HYPOTHESIS: Accumulation of IS is related to FGF‐23 secretion in cats with CKD. ANIMALS: Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. METHODS: The concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. RESULTS: Plasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF‐23 predicted renal progression at a level >0.9. CONCLUSIONS AND CLINICAL IMPORTANCE: Both FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
BackgroundIndoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD.HypothesisAccumulation of IS is related to FGF‐23 secretion in cats with CKD.AnimalsTwenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.MethodsThe concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.ResultsPlasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF‐23 predicted renal progression at a level >0.9.Conclusions and Clinical ImportanceBoth FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD.BACKGROUNDIndoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD.Accumulation of IS is related to FGF-23 secretion in cats with CKD.HYPOTHESISAccumulation of IS is related to FGF-23 secretion in cats with CKD.Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.ANIMALSTwenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.The concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.METHODSThe concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.Plasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9.RESULTSPlasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9.Both FGF-23 and IS are associated with phosphate metabolism and CKD progression.CONCLUSIONS AND CLINICAL IMPORTANCEBoth FGF-23 and IS are associated with phosphate metabolism and CKD progression.
Author Liao, Yu‐Lun
Lee, Ya‐Jane
Chou, Chi‐Chung
AuthorAffiliation 2 Department and Graduate Institute of Pharmacology National Defense Medical Center Taipei Taiwan
3 Institute of Veterinary Clinical Science, School of Veterinary Medicine, College of Bio‐Resources and Agriculture, National Taiwan University Taipei Taiwan
1 Department of Veterinary Medicine College of Veterinary Medicine, National Chung‐Hsing University Taichung Taiwan
4 National Taiwan University Veterinary Hospital College of Bio‐Resources and Agriculture, National Taiwan University Taipei Taiwan
AuthorAffiliation_xml – name: 4 National Taiwan University Veterinary Hospital College of Bio‐Resources and Agriculture, National Taiwan University Taipei Taiwan
– name: 1 Department of Veterinary Medicine College of Veterinary Medicine, National Chung‐Hsing University Taichung Taiwan
– name: 2 Department and Graduate Institute of Pharmacology National Defense Medical Center Taipei Taiwan
– name: 3 Institute of Veterinary Clinical Science, School of Veterinary Medicine, College of Bio‐Resources and Agriculture, National Taiwan University Taipei Taiwan
Author_xml – sequence: 1
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  surname: Liao
  fullname: Liao, Yu‐Lun
  organization: College of Veterinary Medicine, National Chung‐Hsing University
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  givenname: Chi‐Chung
  surname: Chou
  fullname: Chou, Chi‐Chung
  organization: National Defense Medical Center
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  givenname: Ya‐Jane
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  surname: Lee
  fullname: Lee, Ya‐Jane
  email: yajanelee@ntu.edu.tw
  organization: College of Bio‐Resources and Agriculture, National Taiwan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30779214$$D View this record in MEDLINE/PubMed
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Keywords azotemia
progression
uremic toxin
phosphate regulator
feline renal diseases
Language English
License Attribution-NonCommercial
2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Funding information Ministry of Science and Technology, Taiwan, Grant/Award Number: MOST 107‐2313‐B‐002‐053
Liao and Chou contributed equally to this study.
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Snippet Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor...
Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone...
BackgroundIndoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated...
BACKGROUND: Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor...
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SourceType Open Access Repository
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StartPage 686
SubjectTerms Animals
azotemia
Biochemistry
blood serum
Case-Control Studies
Cat Diseases - blood
Cats
Chromatography
Chromatography, High Pressure Liquid - veterinary
creatinine
Disease Progression
enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
feline renal diseases
Female
fibroblast growth factors
Fibroblast Growth Factors - blood
Fibroblasts
Growth factors
high performance liquid chromatography
Indican - blood
Kidney diseases
Laboratory animals
Male
Medical prognosis
Metabolism
phosphate regulator
phosphates
progression
Proteins
renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - veterinary
Retrospective Studies
secretion
Severity of Illness Index
SMALL ANIMAL
Studies
sulfates
uremic toxin
Urinalysis
Urine
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Title The association of indoxyl sulfate with fibroblast growth factor‐23 in cats with chronic kidney disease
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvim.15457
https://www.ncbi.nlm.nih.gov/pubmed/30779214
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https://pubmed.ncbi.nlm.nih.gov/PMC6430881
Volume 33
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