Modulation of Wnt and Hedgehog Signaling Pathways Is Linked to Retinoic Acid‐Induced Amelioration of Chronic Allograft Dysfunction

• Published in: American journal of transplantation Vol. 12; no. 1; pp. 55 - 68
• Main Authors: von Toerne, C., Bedke, J., Safi, S., Porubsky, S., Gretz, N., Loewe, R., Nelson, P. J., Gröne, H.‐J.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2012; Wiley
• Subjects: Animals; Biological and medical sciences; Chronic allograft dysfunction; Hedgehog Proteins - metabolism; Hedgehog signaling; Medical sciences; Rats; Rats, Inbred F344; renal transplantation; retinoic acid; Signal Transduction; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tretinoin - metabolism; Wnt Proteins - metabolism; Wnt signaling; Protein wnt; renal transplantation; Retinoid; Homograft; Hedgehog signaling; Homotransplantation; Kidney; Signal transduction; Chronic; Wnt signaling; Treatment; Urinary system; Signaling pathway; Dysfunction; Hedgehog protein; Surgery; Modulation; Graft; Retinoic acid; Chronic allograft dysfunction; Kidney transplantation

Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic p...