Modulation of Wnt and Hedgehog Signaling Pathways Is Linked to Retinoic Acid‐Induced Amelioration of Chronic Allograft Dysfunction

Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic p...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of transplantation Vol. 12; no. 1; pp. 55 - 68
Main Authors von Toerne, C., Bedke, J., Safi, S., Porubsky, S., Gretz, N., Loewe, R., Nelson, P. J., Gröne, H.‐J.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.01.2012
Wiley
Subjects
Animals
Biological and medical sciences
Chronic allograft dysfunction
Hedgehog Proteins - metabolism
Hedgehog signaling
Medical sciences
Rats
Rats, Inbred F344
renal transplantation
retinoic acid
Signal Transduction
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tretinoin - metabolism
Wnt Proteins - metabolism
Wnt signaling
Protein wnt
renal transplantation
Retinoid
Homograft
Hedgehog signaling
Homotransplantation
Kidney
Signal transduction
Chronic
Wnt signaling
Treatment
Urinary system
Signaling pathway
Dysfunction
Hedgehog protein
Surgery
Modulation
Graft
Retinoic acid
Chronic allograft dysfunction
Kidney transplantation
Online AccessGet full text

Cover

Abstract Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic profiling and pathway mapping, we have previously shown that dynamic dysregulation of the Wnt signaling pathways may underlie progressive CAD. Retinoic acid, an important regulator of differentiation during vertebrate embryogenesis, can moderate the damage observed in this experimental model of CAD. We show here that subsets of the Hedgehog (Hh) and canonical Wnt signaling pathways are linked to the pathophysiology of progressive fibrosis, loss of cilia in epithelia and chronic dysfunction. Oral treatment with 13cis retinoic acid (13cRA) was found to selectively ameliorate the dysregulation of the Hh and canonical Wnt pathways associated with CAD, and lead to a general preservation of cilial structures. Interplay between these pathways helps explain the therapeutic effects of retinoic acid treatment in CAD, and suggests future targets for moderating chronic fibrosing organ damage. Dysregulation of Wnt and Hedgehog signaling pathways may underlie important aspects of progressive experimental allograft damage, and explain the mollifying effects of retinoic acid treatment on chronic damage. See editorial by Fabian and Humphreys on page 5.
AbstractList Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic profiling and pathway mapping, we have previously shown that dynamic dysregulation of the Wnt signaling pathways may underlie progressive CAD. Retinoic acid, an important regulator of differentiation during vertebrate embryogenesis, can moderate the damage observed in this experimental model of CAD. We show here that subsets of the Hedgehog (Hh) and canonical Wnt signaling pathways are linked to the pathophysiology of progressive fibrosis, loss of cilia in epithelia and chronic dysfunction. Oral treatment with 13cis retinoic acid (13cRA) was found to selectively ameliorate the dysregulation of the Hh and canonical Wnt pathways associated with CAD, and lead to a general preservation of cilial structures. Interplay between these pathways helps explain the therapeutic effects of retinoic acid treatment in CAD, and suggests future targets for moderating chronic fibrosing organ damage.
Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic profiling and pathway mapping, we have previously shown that dynamic dysregulation of the Wnt signaling pathways may underlie progressive CAD. Retinoic acid, an important regulator of differentiation during vertebrate embryogenesis, can moderate the damage observed in this experimental model of CAD. We show here that subsets of the Hedgehog (Hh) and canonical Wnt signaling pathways are linked to the pathophysiology of progressive fibrosis, loss of cilia in epithelia and chronic dysfunction. Oral treatment with 13cis retinoic acid (13cRA) was found to selectively ameliorate the dysregulation of the Hh and canonical Wnt pathways associated with CAD, and lead to a general preservation of cilial structures. Interplay between these pathways helps explain the therapeutic effects of retinoic acid treatment in CAD, and suggests future targets for moderating chronic fibrosing organ damage. Dysregulation of Wnt and Hedgehog signaling pathways may underlie important aspects of progressive experimental allograft damage, and explain the mollifying effects of retinoic acid treatment on chronic damage. See editorial by Fabian and Humphreys on page 5.
Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis and tubular atrophy with loss of tubular structures. Using a Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model, transcriptomic profiling and pathway mapping, we have previously shown that dynamic dysregulation of the Wnt signaling pathways may underlie progressive CAD. Retinoic acid, an important regulator of differentiation during vertebrate embryogenesis, can moderate the damage observed in this experimental model of CAD. We show here that subsets of the Hedgehog (Hh) and canonical Wnt signaling pathways are linked to the pathophysiology of progressive fibrosis, loss of cilia in epithelia and chronic dysfunction. Oral treatment with 13cis retinoic acid (13cRA) was found to selectively ameliorate the dysregulation of the Hh and canonical Wnt pathways associated with CAD, and lead to a general preservation of cilial structures. Interplay between these pathways helps explain the therapeutic effects of retinoic acid treatment in CAD, and suggests future targets for moderating chronic fibrosing organ damage. Dysregulation of Wnt and Hedgehog signaling pathways may underlie important aspects of progressive experimental allograft damage, and explain the mollifying effects of retinoic acid treatment on chronic damage. See editorial by Fabian and Humphreys on page 5.
Author Gretz, N.
Gröne, H.‐J.
Bedke, J.
Nelson, P. J.
von Toerne, C.
Safi, S.
Porubsky, S.
Loewe, R.
Author_xml – sequence: 1
  givenname: C.
  surname: von Toerne
  fullname: von Toerne, C.
– sequence: 2
  givenname: J.
  surname: Bedke
  fullname: Bedke, J.
– sequence: 3
  givenname: S.
  surname: Safi
  fullname: Safi, S.
– sequence: 4
  givenname: S.
  surname: Porubsky
  fullname: Porubsky, S.
– sequence: 5
  givenname: N.
  surname: Gretz
  fullname: Gretz, N.
– sequence: 6
  givenname: R.
  surname: Loewe
  fullname: Loewe, R.
– sequence: 7
  givenname: P. J.
  surname: Nelson
  fullname: Nelson, P. J.
– sequence: 8
  givenname: H.‐J.
  surname: Gröne
  fullname: Gröne, H.‐J.
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25618582$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/21992189$$D View this record in MEDLINE/PubMed
BookMark eNqNkctuEzEUQC3Uij7gF5A3CDYZbM_4tWARhUeDgkBQxNJybM_EwbHb8Yza7FjwAXxjv6QzTQg7hDe-0j33pXMGjmKKDgCIUYGH92pdYIbQhOGqLAjCuEAl56y4fQROD4mjQ1zSE3CW8xohzIkgj8EJwVISLOQp-PUx2T7ozqcIUw2_xw7qaOGFs41bpQZ-9U3UwccGftbd6kZvM5xnuPDxh7OwS_CL63xM3sCp8fbu5-95tL0ZUtONCz61h8azVZviiIWQmlbXHXyzzXUfzQg8Ace1Dtk93f_n4Nu7t5ezi8ni0_v5bLqYmEpgNqkdl9ZWlWGiwraihGFXMittiTitjaOScaTdsiqRoZWQxGBNBpzYJaOMk_IcvNj1vWrTde9ypzY-GxeCji71WUnMKJFcsIF8-U8Sc0FJyTGRAyp2qGlTzq2r1VXrN7rdKozUaEut1ShCjVLUaEs92FK3Q-mz_ZR-uXH2UPhHzwA83wM6Gx3qVkfj81-OMiyoGA97veNufHDb_15ATT9cjlF5Dwrasro
CitedBy_id crossref_primary_10_33549_physiolres_932289
crossref_primary_10_1042_CS20201038
crossref_primary_10_1111_ajt_16287
crossref_primary_10_1007_s40620_020_00726_z
crossref_primary_10_1186_s13104_019_4738_6
crossref_primary_10_1371_journal_pone_0141462
crossref_primary_10_1016_j_ajpath_2017_04_002
crossref_primary_10_1097_TP_0000000000001393
Cites_doi 10.1002/jor.1100160212
10.1097/01.tp.0000251373.17997.9a
10.1194/jlr.R100015-JLR200
10.1096/fasebj.13.11.1371
10.1126/science.1098020
10.1007/s00109-003-0517-9
10.3233/CBM-2007-34-510
10.1093/nar/28.1.27
10.1016/S0960-9822(00)80088-3
10.1016/j.ajpath.2011.03.019
10.1073/pnas.0605029103
10.1681/ASN.2008060566
10.1016/j.bbrc.2005.01.110
10.1038/nrm1622
10.1182/blood-2007-06-096438
10.1111/j.1600-6143.2006.01261.x
10.1016/S0002-9440(10)62973-2
10.1242/dev.016204
10.1097/01.tp.0000190423.82154.01
10.1038/nm.1959
10.1369/jhc.5A6899.2006
10.1073/pnas.0912228107
10.1074/jbc.274.23.16641
10.1016/j.gep.2009.06.003
10.1091/mbc.e06-08-0743
10.1074/jbc.M109.053926
10.1186/gb-2003-4-10-r70
10.1093/nar/gkj102
10.1038/nrg2340
10.1681/ASN.2005111187
10.1016/j.molimm.2010.07.017
10.1126/science.1145697
10.2741/3035
10.1242/jcs.00313
10.1111/j.1600-6143.2009.02762.x
10.4161/cbt.5.9.3151
10.1111/j.1524-475X.2008.00430.x
10.1038/35077219
10.1186/gb-2003-4-9-r60
10.1242/dev.01308
10.1016/j.tcb.2006.09.007
10.1016/j.ceb.2007.10.008
10.1242/dev.022087
10.1681/ASN.2008101105
10.2500/ajr.2008.22.3176
10.1111/j.1600-6143.2006.01654.x
10.1016/j.cub.2009.05.025
10.2353/ajpath.2010.090370
10.1242/dev.050450
10.1016/j.jsb.2006.11.004
10.1016/j.ydbio.2011.04.018
10.1038/ng1304
10.1074/jbc.C600200200
10.1152/ajprenal.00343.2002
10.1371/journal.pone.0002142
10.1371/journal.pone.0002937
10.1681/ASN.2008050456
10.1038/nrm778
10.1016/S0070-2153(08)00810-7
ContentType Journal Article
Copyright ©
2015 INIST-CNRS
Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons.
Copyright_xml – notice: ©
– notice: 2015 INIST-CNRS
– notice: Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons.
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7T5
H94
7X8
DOI 10.1111/j.1600-6143.2011.03776.x
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Immunology Abstracts
AIDS and Cancer Research Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
AIDS and Cancer Research Abstracts
Immunology Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE
AIDS and Cancer Research Abstracts
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 1600-6143
EndPage 68
ExternalDocumentID 10_1111_j_1600_6143_2011_03776_x
21992189
25618582
AJT3776
Genre article
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
.3N
.GA
.Y3
05W
0SF
10A
1OC
23M
24P
2WC
31~
33P
36B
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5VS
66C
6J9
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AALRI
AAONW
AASGY
AAXRX
AAXUO
AAZKR
ABCQN
ABCUV
ABEML
ABJNI
ABPPZ
ABPVW
ABXGK
ACAHQ
ACCFJ
ACCZN
ACGFO
ACGFS
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADVLN
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIMD
AENEX
AEQDE
AEUQT
AFBPY
AFEBI
AFGKR
AFPWT
AFZJQ
AHMBA
AIACR
AIAGR
AITUG
AIURR
AIWBW
AJAOE
AJBDE
AKRWK
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMRAJ
AMYDB
ATUGU
AZBYB
AZVAB
BAFTC
BAWUL
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CAG
COF
CS3
D-6
D-7
D-E
D-F
DCZOG
DIK
DPXWK
DR2
DRFUL
DRMAN
DRSTM
E3Z
EBS
EJD
ESX
EX3
F00
F01
F04
F5P
FDB
FIJ
FUBAC
G-S
G.N
GODZA
GX1
H.X
HF~
HZI
HZ~
IHE
IPNFZ
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M41
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OK1
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PQQKQ
Q.N
Q11
QB0
R.K
ROL
RX1
SUPJJ
TEORI
TR2
UB1
V8K
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WIN
WOHZO
WOW
WQJ
WRC
WVDHM
WXI
XG1
YFH
YUY
ZZTAW
~IA
~WT
0R~
AAJUZ
AAPBV
AAVGM
ABCVL
ABHUG
ABPTK
ACXME
ADAWD
ADDAD
AFVGU
AGJLS
BFHJK
IQODW
ZA5
AFJKZ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7T5
H94
7X8
ID FETCH-LOGICAL-c4816-fe79dd44c6841d45261e36d9d3075fce59670aeb430c54892c1a244c2db656723
IEDL.DBID DR2
ISSN 1600-6135
IngestDate Fri Oct 25 05:32:43 EDT 2024
Fri Oct 25 10:34:43 EDT 2024
Thu Sep 26 19:33:24 EDT 2024
Sat Sep 28 08:16:26 EDT 2024
Sun Oct 22 16:09:26 EDT 2023
Sat Aug 24 01:10:59 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Protein wnt
renal transplantation
Retinoid
Homograft
Hedgehog signaling
Homotransplantation
Kidney
Signal transduction
Chronic
Wnt signaling
Treatment
Urinary system
Signaling pathway
Dysfunction
Hedgehog protein
Surgery
Modulation
Graft
Retinoic acid
Chronic allograft dysfunction
Kidney transplantation
Language English
License CC BY 4.0
Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4816-fe79dd44c6841d45261e36d9d3075fce59670aeb430c54892c1a244c2db656723
Notes Equal contribution by the authors.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://www.amjtransplant.org/article/S1600613522272670/pdf
PMID 21992189
PQID 1785237129
PQPubID 23462
PageCount 14
ParticipantIDs proquest_miscellaneous_916529786
proquest_miscellaneous_1785237129
crossref_primary_10_1111_j_1600_6143_2011_03776_x
pubmed_primary_21992189
pascalfrancis_primary_25618582
wiley_primary_10_1111_j_1600_6143_2011_03776_x_AJT3776
PublicationCentury 2000
PublicationDate January 2012
2012
2012-Jan
2012-01-00
20120101
PublicationDateYYYYMMDD 2012-01-01
PublicationDate_xml – month: 01
  year: 2012
  text: January 2012
PublicationDecade 2010
PublicationPlace Malden, USA
PublicationPlace_xml – name: Malden, USA
– name: Hoboken, NJ
– name: United States
PublicationTitle American journal of transplantation
PublicationTitleAlternate Am J Transplant
PublicationYear 2012
Publisher Blackwell Publishing Inc
Wiley
Publisher_xml – name: Blackwell Publishing Inc
– name: Wiley
References 2011; 355
2003; 116
2006; 34
2010; 107
1967; 61
2008; 36
2008; 9
2008; 3
1998; 16
2004; 131
2004; 36
2002; 43
1999; 13
2003; 4
2007; 7
2008; 22
2006; 281
2007; 3
2008; 111
2009; 19
2009; 15
2001; 411
2003; 284
2011; 138
2007; 18
2007; 19
2011; 179
2009; 20
2000; 28
2004; 82
2006; 54
2006; 16
2006; 17
2008; 16
2006; 5
2006; 18
2002; 3
2006; 6
2010; 285
2008; 13
2004; 304
2009; 136
1999; 9
2006; 81
2007; 158
2009; 34
2010; 48
2007; 317
2005; 167
2010; 176
1999; 274
2009; 9
2005; 329
2005; 6
2007; 83
2008; 85
2006; 103
21967111 - Am J Transplant. 2012 Jan;12(1):5-6
Hooper (10.1111/j.1600-6143.2011.03776.x_bib33) 2005; 6
Königshoff (10.1111/j.1600-6143.2011.03776.x_bib7) 2008; 3
Christensen (10.1111/j.1600-6143.2011.03776.x_bib60) 2008; 85
He (10.1111/j.1600-6143.2011.03776.x_bib5) 2009; 20
Oro (10.1111/j.1600-6143.2011.03776.x_bib30) 2007; 19
Mitu (10.1111/j.1600-6143.2011.03776.x_bib52) 2008; 13
Shimoyama (10.1111/j.1600-6143.2011.03776.x_bib34) 2007; 18
Niederreither (10.1111/j.1600-6143.2011.03776.x_bib32) 2008; 9
Kiss (10.1111/j.1600-6143.2011.03776.x_bib19) 2011; 179
Gongal (10.1111/j.1600-6143.2011.03776.x_bib57) 2011; 355
Erickson (10.1111/j.1600-6143.2011.03776.x_bib56) 2008; 22
Marklund (10.1111/j.1600-6143.2011.03776.x_bib12) 2004; 131
Cohen (10.1111/j.1600-6143.2011.03776.x_bib27) 2008; 3
Grone (10.1111/j.1600-6143.2011.03776.x_bib26) 1999; 13
Balmer (10.1111/j.1600-6143.2011.03776.x_bib41) 2002; 43
Grimsrud (10.1111/j.1600-6143.2011.03776.x_bib53) 1998; 16
Choi (10.1111/j.1600-6143.2011.03776.x_bib13) 2005; 329
Hosack (10.1111/j.1600-6143.2011.03776.x_bib22) 2003; 4
Ascenzi (10.1111/j.1600-6143.2011.03776.x_bib40) 2007; 158
Yu (10.1111/j.1600-6143.2011.03776.x_bib42) 2009; 136
Bertrand (10.1111/j.1600-6143.2011.03776.x_bib62) 2006; 16
Le (10.1111/j.1600-6143.2011.03776.x_bib48) 2008; 16
Lin (10.1111/j.1600-6143.2011.03776.x_bib61) 2010; 107
Kanehisa (10.1111/j.1600-6143.2011.03776.x_bib23) 2008; 36
Kanehisa (10.1111/j.1600-6143.2011.03776.x_bib24) 2000; 28
van den Brink (10.1111/j.1600-6143.2011.03776.x_bib55) 2004; 36
Easwaran (10.1111/j.1600-6143.2011.03776.x_bib63) 1999; 9
Kiss (10.1111/j.1600-6143.2011.03776.x_bib18) 2010; 176
Zeisberg (10.1111/j.1600-6143.2011.03776.x_bib37) 2004; 82
Katoh (10.1111/j.1600-6143.2011.03776.x_bib49) 2006; 17
von Toerne (10.1111/j.1600-6143.2011.03776.x_bib4) 2010; 48
Lum (10.1111/j.1600-6143.2011.03776.x_bib46) 2004; 304
Katoh (10.1111/j.1600-6143.2011.03776.x_bib54) 2009; 34
Mannon (10.1111/j.1600-6143.2011.03776.x_bib2) 2006; 6
Hildebrandt (10.1111/j.1600-6143.2011.03776.x_bib31) 2009; 20
Kessenbrock (10.1111/j.1600-6143.2011.03776.x_bib20) 2009; 15
Adams (10.1111/j.1600-6143.2011.03776.x_bib10) 2005; 167
Christensen (10.1111/j.1600-6143.2011.03776.x_bib50) 2002; 3
Tehrani (10.1111/j.1600-6143.2011.03776.x_bib59) 2011; 138
Berbari (10.1111/j.1600-6143.2011.03776.x_bib28) 2009; 19
Katoh (10.1111/j.1600-6143.2011.03776.x_bib38) 2006; 5
Verghese (10.1111/j.1600-6143.2011.03776.x_bib39) 2009; 20
Caruso-Neves (10.1111/j.1600-6143.2011.03776.x_bib51) 2006; 103
Surendran (10.1111/j.1600-6143.2011.03776.x_bib8) 2003; 284
Zhao (10.1111/j.1600-6143.2011.03776.x_bib11) 2009; 9
Mucida (10.1111/j.1600-6143.2011.03776.x_bib15) 2007; 317
Morales (10.1111/j.1600-6143.2011.03776.x_bib29) 2006; 54
McCarthy (10.1111/j.1600-6143.2011.03776.x_bib64) 2003; 116
Mas (10.1111/j.1600-6143.2011.03776.x_bib3) 2007; 83
Dennis (10.1111/j.1600-6143.2011.03776.x_bib21) 2003; 4
Lee (10.1111/j.1600-6143.2011.03776.x_bib16) 1967; 61
Kanehisa (10.1111/j.1600-6143.2011.03776.x_bib25) 2006; 34
Taipale (10.1111/j.1600-6143.2011.03776.x_bib35) 2001; 411
Easwaran (10.1111/j.1600-6143.2011.03776.x_bib44) 1999; 274
Pishvaian (10.1111/j.1600-6143.2011.03776.x_bib43) 2007; 3
von Toerne (10.1111/j.1600-6143.2011.03776.x_bib9) 2009; 9
Katoh (10.1111/j.1600-6143.2011.03776.x_bib47) 2006; 18
Yoshikawa (10.1111/j.1600-6143.2011.03776.x_bib36) 2007; 18
Ribes (10.1111/j.1600-6143.2011.03776.x_bib58) 2009; 136
He (10.1111/j.1600-6143.2011.03776.x_bib6) 2006; 281
Elias (10.1111/j.1600-6143.2011.03776.x_bib14) 2008; 111
Yasuhara (10.1111/j.1600-6143.2011.03776.x_bib45) 2010; 285
Bedke (10.1111/j.1600-6143.2011.03776.x_bib17) 2007; 7
Nankivell (10.1111/j.1600-6143.2011.03776.x_bib1) 2006; 81
References_xml – volume: 85
  start-page: 261
  year: 2008
  end-page: 301
  article-title: The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
  publication-title: Curr Top Dev Biol
– volume: 284
  start-page: F653
  year: 2003
  end-page: F662
  article-title: CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
  publication-title: Am J Physiol Renal Physiol
– volume: 329
  start-page: 125
  year: 2005
  end-page: 131
  article-title: Anti‐inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon‐gamma‐induced JAK/STAT phosphorylation
  publication-title: Biochem Biophys Res Commun
– volume: 61
  start-page: 771
  year: 1967
  end-page: 773
  article-title: An improved technique of renal transplantation in the rat
  publication-title: Surgery
– volume: 4
  start-page: R70
  year: 2003
  article-title: Identifying biological themes within lists of genes with EASE
  publication-title: Genome Biol
– volume: 304
  start-page: 1755
  year: 2004
  end-page: 1759
  article-title: The Hedgehog response network: Sensors, switches, and routers
  publication-title: Science
– volume: 111
  start-page: 1013
  year: 2008
  end-page: 1020
  article-title: Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat‐3/Stat‐5 independent signaling pathway
  publication-title: Blood
– volume: 18
  start-page: 58
  year: 2007
  end-page: 65
  article-title: Inhibition of histone deacetylase activity suppresses epithelial‐to‐mesenchymal transition induced by TGF‐beta1 in human renal epithelial cells
  publication-title: J Am Soc Nephrol
– volume: 20
  start-page: 2147
  year: 2009
  end-page: 2153
– volume: 136
  start-page: 665
  year: 2009
  end-page: 676
  article-title: Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways
  publication-title: Development
– volume: 16
  start-page: 597
  year: 2006
  end-page: 605
  article-title: Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects
  publication-title: Trends Cell Biol
– volume: 136
  start-page: 161
  year: 2009
  end-page: 171
  article-title: A Wnt7b‐dependent pathway regulates the orientation of epithelial cell division and establishes the cortico‐medullary axis of the mammalian kidney
  publication-title: Development
– volume: 281
  start-page: 35598
  year: 2006
  end-page: 35602
  article-title: Suppressing Wnt signaling by the hedgehog pathway through sFRP‐1
  publication-title: J Biol Chem
– volume: 43
  start-page: 1773
  year: 2002
  end-page: 1808
  article-title: Gene expression regulation by retinoic acid 10.1194/jlr.R100015‐JLR200
  publication-title: J Lipid Res
– volume: 167
  start-page: 285
  year: 2005
  end-page: 298
  article-title: 13‐cis retinoic acid inhibits development and progression of chronic allograft nephropathy
  publication-title: Am J Pathol
– volume: 15
  start-page: 623
  year: 2009
  end-page: 625
  article-title: Netting neutrophils in autoimmune small‐vessel vasculitis
  publication-title: Nat Med
– volume: 158
  start-page: 293
  year: 2007
  end-page: 306
  article-title: Analysis of the orientation of primary cilia in growth plate cartilage: A mathematical method based on multiphoton microscopical images
  publication-title: J Struct Biol
– volume: 13
  start-page: 4726
  year: 2008
  end-page: 4739
  article-title: Bone morphogenetic protein‐7 (BMP7) in chronic kidney disease
  publication-title: Front Biosci
– volume: 82
  start-page: 175
  year: 2004
  end-page: 181
  article-title: The role of epithelial‐to‐mesenchymal transition in renal fibrosis
  publication-title: J Mol Med
– volume: 6
  start-page: 306
  year: 2005
  end-page: 317
  article-title: Communicating with hedgehogs
  publication-title: Nat Rev Mol Cell Biol
– volume: 3
  start-page: 256
  year: 2002
  end-page: 266
  article-title: Megalin and cubilin: Multifunctional endocytic receptors
  publication-title: Nat Rev Mol Cell Biol
– volume: 176
  start-page: 2150
  year: 2010
  end-page: 2162
  article-title: Peroxisome proliferator‐activated receptor (PPAR)gamma can inhibit chronic renal allograft damage
  publication-title: Am J Pathol
– volume: 36
  start-page: D480
  issue: Database issue
  year: 2008
  end-page: D484
  article-title: KEGG for linking genomes to life and the environment
  publication-title: Nucleic Acids Res
– volume: 7
  start-page: 527
  year: 2007
  end-page: 537
  article-title: Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage
  publication-title: Am J Transplant
– volume: 13
  start-page: 1371
  year: 1999
  end-page: 1383
  article-title: Met‐RANTES reduces vascular and tubular damage during acute renal transplant rejection: Blocking monocyte arrest and recruitment
  publication-title: FASEB J
– volume: 9
  start-page: 1415
  year: 1999
  end-page: 1418
  article-title: Cross‐regulation of beta‐catenin‐LEF/TCF and retinoid signaling pathways
  publication-title: Curr Biol
– volume: 16
  start-page: 768
  year: 2008
  end-page: 773
– volume: 34
  start-page: D354
  issue: Database issue
  year: 2006
  end-page: D357
  article-title: From genomics to chemical genomics: New developments in KEGG
  publication-title: Nucleic Acids Res
– volume: 9
  start-page: 541
  year: 2008
  end-page: 553
  article-title: Retinoic acid in development: Towards an integrated view
  publication-title: Nat Rev Genet
– volume: 3
  start-page: e2142
  year: 2008
  article-title: Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
  publication-title: PLoS ONE
– volume: 6
  start-page: 867
  issue: 5 Pt 1
  year: 2006
  end-page: 875
  article-title: Therapeutic targets in the treatment of allograft fibrosis
  publication-title: Am J Transplant
– volume: 9
  start-page: 2223
  year: 2009
  end-page: 2239
  article-title: Wnt pathway regulation in chronic renal allograft damage
  publication-title: Am J Transplant
– volume: 5
  start-page: 1059
  year: 2006
  end-page: 1064
  article-title: Cross‐talk of WNT and FGF signaling pathways at GSK3beta to regulate beta‐catenin and SNAIL signaling cascades
  publication-title: Cancer Biol Ther
– volume: 54
  start-page: 1115
  year: 2006
  end-page: 1127
  article-title: Epithelial trafficking of Sonic hedgehog by megalin
  publication-title: J Histochem Cytochem
– volume: 17
  start-page: 171
  year: 2006
  end-page: 175
  article-title: WNT antagonist, SFRP1, is Hedgehog signaling target
  publication-title: Int J Mol Med
– volume: 34
  start-page: 1411
  year: 2009
  end-page: 1415
  article-title: Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals
  publication-title: Int J Oncol
– volume: 18
  start-page: 2411
  year: 2007
  end-page: 2418
  article-title: Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
  publication-title: Mol Biol Cell
– volume: 274
  start-page: 16641
  year: 1999
  end-page: 16645
  article-title: The ubiquitin‐proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein‐mediated regulation of beta‐catenin‐lymphocyte enhancer‐binding factor signaling
  publication-title: J Biol Chem
– volume: 317
  start-page: 256
  year: 2007
  end-page: 260
  article-title: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
  publication-title: Science
– volume: 20
  start-page: 765
  year: 2009
  end-page: 776
  article-title: Wnt/beta‐catenin signaling promotes renal interstitial fibrosis
  publication-title: J Am Soc Nephrol
– volume: 3
  start-page: 263
  year: 2007
  end-page: 274
  article-title: Biomarkers of WNT signaling
  publication-title: Cancer Biomark
– volume: 9
  start-page: 430
  year: 2009
  end-page: 435
  article-title: Effect of retinoic acid signaling on Wnt/beta‐catenin and FGF signaling during body axis extension
  publication-title: Gene Expr Patterns
– volume: 18
  start-page: 1019
  year: 2006
  end-page: 1023
  article-title: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
  publication-title: Int J Mol Med
– volume: 138
  start-page: 631
  year: 2011
  end-page: 640
  article-title: Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development
  publication-title: Development
– volume: 355
  start-page: 55
  year: 2011
  end-page: 64
– volume: 16
  start-page: 247
  year: 1998
  end-page: 255
  article-title: Bone morphogenetic protein‐7 in growth‐plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation
  publication-title: J Orthop Res
– volume: 107
  start-page: 4194
  year: 2010
  end-page: 4199
– volume: 36
  start-page: 277
  year: 2004
  end-page: 282
  article-title: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
  publication-title: Nat Genet
– volume: 48
  start-page: 272
  year: 2010
  end-page: 280
  article-title: Effector T cells driving monophasic vs. relapsing/remitting experimental autoimmune uveitis show unique pathway signatures
  publication-title: Mol Immunol
– volume: 28
  start-page: 27
  year: 2000
  end-page: 30
  article-title: KEGG: Kyoto encyclopedia of genes and genomes
  publication-title: Nucleic Acids Res
– volume: 83
  start-page: 448
  year: 2007
  end-page: 457
  article-title: Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markers
  publication-title: Transplantation
– volume: 19
  start-page: 691
  year: 2007
  end-page: 696
  article-title: The primary cilia, a ‘Rab‐id’ transit system for hedgehog signaling
  publication-title: Curr Opin Cell Biol
– volume: 116
  start-page: 955
  issue: Pt 6
  year: 2003
  end-page: 960
  article-title: Megalin and the neurodevelopmental biology of sonic hedgehog and retinol
  publication-title: J Cell Sci
– volume: 19
  start-page: R526
  year: 2009
  end-page: R535
  article-title: The primary cilium as a complex signaling center
  publication-title: Curr Biol
– volume: 285
  start-page: 317
  year: 2010
  end-page: 327
  article-title: Wnt/beta‐catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover
  publication-title: J Biol Chem
– volume: 22
  start-page: 334
  year: 2008
  end-page: 336
  article-title: The effects of retinoic acid on ciliary function of regenerated sinus mucosa
  publication-title: Am J Rhinol
– volume: 131
  start-page: 4323
  year: 2004
  end-page: 4332
  article-title: Retinoic acid signalling specifies intermediate character in the developing telencephalon
  publication-title: Development
– volume: 411
  start-page: 349
  year: 2001
  end-page: 354
  article-title: The Hedgehog and Wnt signalling pathways in cancer
  publication-title: Nature
– volume: 4
  start-page: R60
  year: 2003
  article-title: DAVID: database for annotation, visualization, and integrated discovery
  publication-title: Genome Biol
– volume: 179
  start-page: 92
  year: 2011
  end-page: 103
  article-title: Suppression of chronic damage in renal allografts by liver X receptor (LXR) relevant contribution of macrophage LXRα activation
  publication-title: Am J Pathol
– volume: 3
  start-page: e2937
  year: 2008
  article-title: Improved elucidation of biological processes linked to diabetic nephropathy by single probe‐based microarray data analysis
  publication-title: PLoS One
– volume: 20
  start-page: 23
  year: 2009
  end-page: 35
  article-title: Nephronophthisis: Disease mechanisms of a ciliopathy
  publication-title: J Am Soc Nephrol
– volume: 81
  start-page: 643
  year: 2006
  end-page: 654
  article-title: Chronic allograft nephropathy: Current concepts and future directions
  publication-title: Transplantation
– volume: 103
  start-page: 18810
  year: 2006
  end-page: 18815
  article-title: PKB and megalin determine the survival or death of renal proximal tubule cells
  publication-title: Proc Natl Acad Sci USA
– volume: 16
  start-page: 247
  year: 1998
  ident: 10.1111/j.1600-6143.2011.03776.x_bib53
  article-title: Bone morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation
  publication-title: J Orthop Res
  doi: 10.1002/jor.1100160212
  contributor:
    fullname: Grimsrud
– volume: 83
  start-page: 448
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib3
  article-title: Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markers
  publication-title: Transplantation
  doi: 10.1097/01.tp.0000251373.17997.9a
  contributor:
    fullname: Mas
– volume: 43
  start-page: 1773
  year: 2002
  ident: 10.1111/j.1600-6143.2011.03776.x_bib41
  article-title: Gene expression regulation by retinoic acid
  publication-title: J Lipid Res
  doi: 10.1194/jlr.R100015-JLR200
  contributor:
    fullname: Balmer
– volume: 36
  start-page: D480
  issue: Database issue
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib23
  article-title: KEGG for linking genomes to life and the environment
  publication-title: Nucleic Acids Res
  contributor:
    fullname: Kanehisa
– volume: 13
  start-page: 1371
  year: 1999
  ident: 10.1111/j.1600-6143.2011.03776.x_bib26
  article-title: Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: Blocking monocyte arrest and recruitment
  publication-title: FASEB J
  doi: 10.1096/fasebj.13.11.1371
  contributor:
    fullname: Grone
– volume: 304
  start-page: 1755
  year: 2004
  ident: 10.1111/j.1600-6143.2011.03776.x_bib46
  article-title: The Hedgehog response network: Sensors, switches, and routers
  publication-title: Science
  doi: 10.1126/science.1098020
  contributor:
    fullname: Lum
– volume: 82
  start-page: 175
  year: 2004
  ident: 10.1111/j.1600-6143.2011.03776.x_bib37
  article-title: The role of epithelial-to-mesenchymal transition in renal fibrosis
  publication-title: J Mol Med
  doi: 10.1007/s00109-003-0517-9
  contributor:
    fullname: Zeisberg
– volume: 3
  start-page: 263
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib43
  article-title: Biomarkers of WNT signaling
  publication-title: Cancer Biomark
  doi: 10.3233/CBM-2007-34-510
  contributor:
    fullname: Pishvaian
– volume: 18
  start-page: 1019
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib47
  article-title: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
  publication-title: Int J Mol Med
  contributor:
    fullname: Katoh
– volume: 28
  start-page: 27
  year: 2000
  ident: 10.1111/j.1600-6143.2011.03776.x_bib24
  article-title: KEGG: Kyoto encyclopedia of genes and genomes
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/28.1.27
  contributor:
    fullname: Kanehisa
– volume: 9
  start-page: 1415
  year: 1999
  ident: 10.1111/j.1600-6143.2011.03776.x_bib63
  article-title: Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(00)80088-3
  contributor:
    fullname: Easwaran
– volume: 179
  start-page: 92
  year: 2011
  ident: 10.1111/j.1600-6143.2011.03776.x_bib19
  article-title: Suppression of chronic damage in renal allografts by liver X receptor (LXR) relevant contribution of macrophage LXRα activation
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2011.03.019
  contributor:
    fullname: Kiss
– volume: 103
  start-page: 18810
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib51
  article-title: PKB and megalin determine the survival or death of renal proximal tubule cells
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0605029103
  contributor:
    fullname: Caruso-Neves
– volume: 20
  start-page: 765
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib5
  article-title: Wnt/beta-catenin signaling promotes renal interstitial fibrosis
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2008060566
  contributor:
    fullname: He
– volume: 329
  start-page: 125
  year: 2005
  ident: 10.1111/j.1600-6143.2011.03776.x_bib13
  article-title: Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2005.01.110
  contributor:
    fullname: Choi
– volume: 6
  start-page: 306
  year: 2005
  ident: 10.1111/j.1600-6143.2011.03776.x_bib33
  article-title: Communicating with hedgehogs
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm1622
  contributor:
    fullname: Hooper
– volume: 111
  start-page: 1013
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib14
  article-title: Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
  publication-title: Blood
  doi: 10.1182/blood-2007-06-096438
  contributor:
    fullname: Elias
– volume: 6
  start-page: 867
  issue: 5 Pt 1
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib2
  article-title: Therapeutic targets in the treatment of allograft fibrosis
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2006.01261.x
  contributor:
    fullname: Mannon
– volume: 167
  start-page: 285
  year: 2005
  ident: 10.1111/j.1600-6143.2011.03776.x_bib10
  article-title: 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)62973-2
  contributor:
    fullname: Adams
– volume: 136
  start-page: 665
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib58
  article-title: Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways
  publication-title: Development
  doi: 10.1242/dev.016204
  contributor:
    fullname: Ribes
– volume: 81
  start-page: 643
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib1
  article-title: Chronic allograft nephropathy: Current concepts and future directions
  publication-title: Transplantation
  doi: 10.1097/01.tp.0000190423.82154.01
  contributor:
    fullname: Nankivell
– volume: 15
  start-page: 623
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib20
  article-title: Netting neutrophils in autoimmune small-vessel vasculitis
  publication-title: Nat Med
  doi: 10.1038/nm.1959
  contributor:
    fullname: Kessenbrock
– volume: 54
  start-page: 1115
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib29
  article-title: Epithelial trafficking of Sonic hedgehog by megalin
  publication-title: J Histochem Cytochem
  doi: 10.1369/jhc.5A6899.2006
  contributor:
    fullname: Morales
– volume: 107
  start-page: 4194
  year: 2010
  ident: 10.1111/j.1600-6143.2011.03776.x_bib61
  article-title: Macrophage Wnt7b is critical for kidney repair and regeneration
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0912228107
  contributor:
    fullname: Lin
– volume: 274
  start-page: 16641
  year: 1999
  ident: 10.1111/j.1600-6143.2011.03776.x_bib44
  article-title: The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.23.16641
  contributor:
    fullname: Easwaran
– volume: 9
  start-page: 430
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib11
  article-title: Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension
  publication-title: Gene Expr Patterns
  doi: 10.1016/j.gep.2009.06.003
  contributor:
    fullname: Zhao
– volume: 18
  start-page: 2411
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib34
  article-title: Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e06-08-0743
  contributor:
    fullname: Shimoyama
– volume: 285
  start-page: 317
  year: 2010
  ident: 10.1111/j.1600-6143.2011.03776.x_bib45
  article-title: Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.053926
  contributor:
    fullname: Yasuhara
– volume: 4
  start-page: R70
  year: 2003
  ident: 10.1111/j.1600-6143.2011.03776.x_bib22
  article-title: Identifying biological themes within lists of genes with EASE
  publication-title: Genome Biol
  doi: 10.1186/gb-2003-4-10-r70
  contributor:
    fullname: Hosack
– volume: 34
  start-page: D354
  issue: Database issue
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib25
  article-title: From genomics to chemical genomics: New developments in KEGG
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkj102
  contributor:
    fullname: Kanehisa
– volume: 9
  start-page: 541
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib32
  article-title: Retinoic acid in development: Towards an integrated view
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2340
  contributor:
    fullname: Niederreither
– volume: 18
  start-page: 58
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib36
  article-title: Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2005111187
  contributor:
    fullname: Yoshikawa
– volume: 48
  start-page: 272
  year: 2010
  ident: 10.1111/j.1600-6143.2011.03776.x_bib4
  article-title: Effector T cells driving monophasic vs. relapsing/remitting experimental autoimmune uveitis show unique pathway signatures
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2010.07.017
  contributor:
    fullname: von Toerne
– volume: 317
  start-page: 256
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib15
  article-title: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
  publication-title: Science
  doi: 10.1126/science.1145697
  contributor:
    fullname: Mucida
– volume: 13
  start-page: 4726
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib52
  article-title: Bone morphogenetic protein-7 (BMP7) in chronic kidney disease
  publication-title: Front Biosci
  doi: 10.2741/3035
  contributor:
    fullname: Mitu
– volume: 116
  start-page: 955
  issue: Pt 6
  year: 2003
  ident: 10.1111/j.1600-6143.2011.03776.x_bib64
  article-title: Megalin and the neurodevelopmental biology of sonic hedgehog and retinol
  publication-title: J Cell Sci
  doi: 10.1242/jcs.00313
  contributor:
    fullname: McCarthy
– volume: 9
  start-page: 2223
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib9
  article-title: Wnt pathway regulation in chronic renal allograft damage
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2009.02762.x
  contributor:
    fullname: von Toerne
– volume: 5
  start-page: 1059
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib38
  article-title: Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.5.9.3151
  contributor:
    fullname: Katoh
– volume: 16
  start-page: 768
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib48
  article-title: Hedgehog signaling is essential for normal wound healing
  publication-title: Wound Repair Regen
  doi: 10.1111/j.1524-475X.2008.00430.x
  contributor:
    fullname: Le
– volume: 411
  start-page: 349
  year: 2001
  ident: 10.1111/j.1600-6143.2011.03776.x_bib35
  article-title: The Hedgehog and Wnt signalling pathways in cancer
  publication-title: Nature
  doi: 10.1038/35077219
  contributor:
    fullname: Taipale
– volume: 4
  start-page: R60
  year: 2003
  ident: 10.1111/j.1600-6143.2011.03776.x_bib21
  article-title: DAVID: database for annotation, visualization, and integrated discovery
  publication-title: Genome Biol
  doi: 10.1186/gb-2003-4-9-r60
  contributor:
    fullname: Dennis
– volume: 131
  start-page: 4323
  year: 2004
  ident: 10.1111/j.1600-6143.2011.03776.x_bib12
  article-title: Retinoic acid signalling specifies intermediate character in the developing telencephalon
  publication-title: Development
  doi: 10.1242/dev.01308
  contributor:
    fullname: Marklund
– volume: 17
  start-page: 171
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib49
  article-title: WNT antagonist, SFRP1, is Hedgehog signaling target
  publication-title: Int J Mol Med
  contributor:
    fullname: Katoh
– volume: 16
  start-page: 597
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib62
  article-title: Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2006.09.007
  contributor:
    fullname: Bertrand
– volume: 19
  start-page: 691
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib30
  article-title: The primary cilia, a ‘Rab-id’ transit system for hedgehog signaling
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2007.10.008
  contributor:
    fullname: Oro
– volume: 136
  start-page: 161
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib42
  article-title: A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney
  publication-title: Development
  doi: 10.1242/dev.022087
  contributor:
    fullname: Yu
– volume: 20
  start-page: 2147
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib39
  article-title: Renal primary cilia lengthen after acute tubular necrosis
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2008101105
  contributor:
    fullname: Verghese
– volume: 22
  start-page: 334
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib56
  article-title: The effects of retinoic acid on ciliary function of regenerated sinus mucosa
  publication-title: Am J Rhinol
  doi: 10.2500/ajr.2008.22.3176
  contributor:
    fullname: Erickson
– volume: 7
  start-page: 527
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib17
  article-title: Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2006.01654.x
  contributor:
    fullname: Bedke
– volume: 19
  start-page: R526
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib28
  article-title: The primary cilium as a complex signaling center
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2009.05.025
  contributor:
    fullname: Berbari
– volume: 176
  start-page: 2150
  year: 2010
  ident: 10.1111/j.1600-6143.2011.03776.x_bib18
  article-title: Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2010.090370
  contributor:
    fullname: Kiss
– volume: 138
  start-page: 631
  year: 2011
  ident: 10.1111/j.1600-6143.2011.03776.x_bib59
  article-title: Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development
  publication-title: Development
  doi: 10.1242/dev.050450
  contributor:
    fullname: Tehrani
– volume: 158
  start-page: 293
  year: 2007
  ident: 10.1111/j.1600-6143.2011.03776.x_bib40
  article-title: Analysis of the orientation of primary cilia in growth plate cartilage: A mathematical method based on multiphoton microscopical images
  publication-title: J Struct Biol
  doi: 10.1016/j.jsb.2006.11.004
  contributor:
    fullname: Ascenzi
– volume: 355
  start-page: 55
  year: 2011
  ident: 10.1111/j.1600-6143.2011.03776.x_bib57
  article-title: Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2011.04.018
  contributor:
    fullname: Gongal
– volume: 36
  start-page: 277
  year: 2004
  ident: 10.1111/j.1600-6143.2011.03776.x_bib55
  article-title: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
  publication-title: Nat Genet
  doi: 10.1038/ng1304
  contributor:
    fullname: van den Brink
– volume: 61
  start-page: 771
  year: 1967
  ident: 10.1111/j.1600-6143.2011.03776.x_bib16
  article-title: An improved technique of renal transplantation in the rat
  publication-title: Surgery
  contributor:
    fullname: Lee
– volume: 281
  start-page: 35598
  year: 2006
  ident: 10.1111/j.1600-6143.2011.03776.x_bib6
  article-title: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C600200200
  contributor:
    fullname: He
– volume: 284
  start-page: F653
  year: 2003
  ident: 10.1111/j.1600-6143.2011.03776.x_bib8
  article-title: CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00343.2002
  contributor:
    fullname: Surendran
– volume: 34
  start-page: 1411
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib54
  article-title: Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals
  publication-title: Int J Oncol
  contributor:
    fullname: Katoh
– volume: 3
  start-page: e2142
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib7
  article-title: Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0002142
  contributor:
    fullname: Königshoff
– volume: 3
  start-page: e2937
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib27
  article-title: Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002937
  contributor:
    fullname: Cohen
– volume: 20
  start-page: 23
  year: 2009
  ident: 10.1111/j.1600-6143.2011.03776.x_bib31
  article-title: Nephronophthisis: Disease mechanisms of a ciliopathy
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2008050456
  contributor:
    fullname: Hildebrandt
– volume: 3
  start-page: 256
  year: 2002
  ident: 10.1111/j.1600-6143.2011.03776.x_bib50
  article-title: Megalin and cubilin: Multifunctional endocytic receptors
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm778
  contributor:
    fullname: Christensen
– volume: 85
  start-page: 261
  year: 2008
  ident: 10.1111/j.1600-6143.2011.03776.x_bib60
  article-title: The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
  publication-title: Curr Top Dev Biol
  doi: 10.1016/S0070-2153(08)00810-7
  contributor:
    fullname: Christensen
SSID ssj0017282
Score 2.115222
Snippet Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis...
SourceID proquest
crossref
pubmed
pascalfrancis
wiley
SourceType Aggregation Database
Index Database
Publisher
StartPage 55
SubjectTerms Animals
Biological and medical sciences
Chronic allograft dysfunction
Hedgehog Proteins - metabolism
Hedgehog signaling
Medical sciences
Rats
Rats, Inbred F344
renal transplantation
retinoic acid
Signal Transduction
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tretinoin - metabolism
Wnt Proteins - metabolism
Wnt signaling
Title Modulation of Wnt and Hedgehog Signaling Pathways Is Linked to Retinoic Acid‐Induced Amelioration of Chronic Allograft Dysfunction
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1600-6143.2011.03776.x
https://www.ncbi.nlm.nih.gov/pubmed/21992189
https://search.proquest.com/docview/1785237129
https://search.proquest.com/docview/916529786
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhp0Log76cJkGFXr1YlizZR5MH20BKSROam5AlebuktUPspU1OOfQH9Df2l3TG9m7rkEIpuRlbkqXRjOYbaTRDyBsPSjjxURSmgttQFB5EyqkiZFliGXelURYNxaN3cnoqDs-Ss8H_Ce_C9PEhVhtuKBndeo0CbopmLOSgrMH0EXyIxMmVkhPEk4wr9O7aO15FksIsTN3BZ1-FJ2OnnjsbGmmqjQvTANHKPtvFXXB0jG479XTwiJwvB9Z7pZxPFm0xsde3Yj7ez8gfk4cDiqV5z3ZPyJqvnpLvR7UbkoHRuqQfq5aaytEp7th9qmf0w3yGqL-a0fcAO7-aq4a-bSgaw97RtqbHePu6nlua27n7efMDs4pY-JR_gf4OnIoND_F8af65i7ddtnTvqkH9jAWekdOD_ZPdaTgkeQitSJkMS68y54SwMhXMYcJz5rl0mYPFJynxkphUkfGF4JEF6yqLLTMASWzsCoCiKubPyXpVV_4loWDZRpnhQlpoLyrjFE_VC2NhiUolcGRA2HJC9UUfy0P_YQMBTTXSVCNNdUdT_S0gO6OZX1UEqAhQJ40D8nrJChokE49bTOXrRaOZSsHKVwCoAkL_UgbAeRKDIS8D8qJno98_QMdglkJl2THDP3dZ54cn-LT5vxVfkQfwOu43mrbIenu58NsAvdpipxOqXw-VH6w
link.rule.ids 315,783,787,1378,4031,27935,27936,27937,46306,46730
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQOYCEeIhXeBQjcc0qjh07OUaUalu6FSpb0Zvl2M6yoiQVyQrKiQM_gN_IL2EmyS4EFQkhbpHiceLxjOebsT1DyDMPRjjxURSmgttQFB5UyqkiZFliGXelURYdxdmhnB6L_ZPkZCgHhHdh-vwQm4Abaka3XqOCY0B6rOVgrcH3EXxIxcmVkhMAlJdB-znWcdg52uSSwjpM3dZnT8OT8bGeC3sa2aprZ6YBtpV9vYuLAOkY33YGavcGOV0PrT-X8m6yaouJ_fxb1sf_NPab5PoAZGneS94tcslXt8nXWe2GemC0LumbqqWmcnSKQbu39YK-Xi4Q-FcL-gqQ50dz3tC9hqI_7B1ta3qEF7DrpaW5XbrvX75hYRELr_L38MODsGLHQ0pfmp92KbfLlu6cN2iiscEdcrz7Yv58Gg51HkIrUibD0qvMOSGsTAVzWPOceS5d5mD9SUq8JyZVZHwheGTBwcpiywygEhu7AtCoivldslXVlb9PKDi3UWa4kBb6i8o4xY31wlhYpVIJQhkQtp5Rfdan89C_uEHAU4081chT3fFUfwrI9mjqN4SAFgHtpHFAnq5lQYNy4o6LqXy9ajRTKTj6CjBVQOgf2gA-T2Lw5WVA7vVy9PMDeDaYpUAsO2n461_W-f4cnx78K-ETcmU6nx3og73Dlw_JVWgS93GnR2Sr_bDyjwGJtcV2p2E_AAAyI8Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQkRAS4iFe4VGMxDWrOHbs5BhRVttCq6q0ojfLsZ1lVUhWJCsoJw78AH4jv4SZJLsQVCSEuEWKx4nHM55v7PEMIc88GOHER1GYCm5DUXhQKaeKkGWJZdyVRll0FPcP5OxE7J0mp0P8E96F6fNDbDbcUDO69RoVfOnKsZKDsQbXR_AhEydXSk4AT14WEoAwAqSjTSopLMPUnXz2NDwZR_Vc2NPIVF1bmga4VvblLi7Co2N429mn6Q1yth5ZH5ZyNlm1xcR-_i3p4_8Z-k1yfYCxNO_l7ha55Kvb5Ot-7YZqYLQu6ZuqpaZydIZbdm_rOX29mCPsr-b0EHDnR3Pe0N2GojfsHW1reoTXr-uFpblduO9fvmFZEQuv8vfwv4OoYsdDQl-av-sSbpct3Tlv0EBjgzvkZPri-PksHKo8hFakTIalV5lzQliZCuaw4jnzXLrMweqTlHhLTKrI-ELwyIJ7lcWWGcAkNnYFYFEV87tkq6orf59QcG2jzHAhLfQXlXGKx-qFsbBGpRJEMiBsPaF62Sfz0L84QcBTjTzVyFPd8VR_Csj2aOY3hIAVAeukcUCerkVBg2rieYupfL1qNFMpuPkKEFVA6B_aADpPYvDkZUDu9WL08wMYGcxSIJadMPz1L-t87xifHvwr4RNy5XBnql_tHrx8SK5Ci7jfdHpEttoPK_8YYFhbbHf69QNpIyJz
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Modulation+of+Wnt+and+Hedgehog+Signaling+Pathways+Is+Linked+to+Retinoic+Acid-Induced+Amelioration+of+Chronic+Allograft+Dysfunction&rft.jtitle=American+journal+of+transplantation&rft.au=VON+TOERNE%2C+C&rft.au=BEDKE%2C+J&rft.au=SAFI%2C+S&rft.au=PORUBSKY%2C+S&rft.date=2012&rft.pub=Wiley&rft.issn=1600-6135&rft.eissn=1600-6143&rft.volume=12&rft.issue=1&rft.spage=55&rft.epage=68&rft_id=info:doi/10.1111%2Fj.1600-6143.2011.03776.x&rft.externalDBID=n%2Fa&rft.externalDocID=25618582
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1600-6135&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1600-6135&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1600-6135&client=summon