Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia

• Published in: The journal of clinical endocrinology and metabolism Vol. 99; no. 8; pp. 2887 - 2896
• Main Authors: Collins, Jessicah S., Beller, Jennifer P., Burt Solorzano, Christine, Patrie, James T., Chang, R. Jeffrey, Marshall, John C., McCartney, Christopher R.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.08.2014; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adolescent; Biological and medical sciences; Child; Circadian Rhythm; Cross-Sectional Studies; Endocrine Research; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Girls; Humans; Hyperandrogenism - blood; Luteinizing hormone; Luteinizing Hormone - blood; Luteinizing Hormone - secretion; Medical sciences; Menarche - blood; Obesity; Obesity - blood; Puberty; Puberty - blood; Secretion; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Human; Obesity; Night; Nutrition; Nutrition disorder; Metabolic diseases; Gonadotropin; Change; Adenohypophyseal hormone; Blunted effect; Luteinizing hormone; Female; Frequency; Hyperandrogenism; Child; Endocrinology; Nutritional status

Context:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.Objective:The objective of the study was to test two hypothes...