Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia

Context:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.Objective:The objective of the study was to test two hypothes...

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Published inThe journal of clinical endocrinology and metabolism Vol. 99; no. 8; pp. 2887 - 2896
Main Authors Collins, Jessicah S., Beller, Jennifer P., Burt Solorzano, Christine, Patrie, James T., Chang, R. Jeffrey, Marshall, John C., McCartney, Christopher R.
Format Journal Article
LanguageEnglish
Published Bethesda, MD Oxford University Press 01.08.2014
Copyright by The Endocrine Society
Endocrine Society
Subjects
Adolescent
Biological and medical sciences
Child
Circadian Rhythm
Cross-Sectional Studies
Endocrine Research
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Girls
Humans
Hyperandrogenism - blood
Luteinizing hormone
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Medical sciences
Menarche - blood
Obesity
Obesity - blood
Puberty
Puberty - blood
Secretion
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Endocrinopathy
Human
Obesity
Night
Nutrition
Nutrition disorder
Metabolic diseases
Gonadotropin
Change
Adenohypophyseal hormone
Blunted effect
Luteinizing hormone
Female
Frequency
Hyperandrogenism
Child
Endocrinology
Nutritional status
Online AccessGet full text

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Abstract Context:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.Objective:The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.Design:This was a cross-sectional analysis.Setting:The study was conducted at a clinical research center.Patients or Other Participants:Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.Intervention:Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am.Main Outcome Measure:Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).Results:Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).Conclusions:Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
AbstractList Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown. The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia. This was a cross-sectional analysis. The study was conducted at a clinical research center. Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study. Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am. Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep). Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively). Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
Context:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.Objective:The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.Design:This was a cross-sectional analysis.Setting:The study was conducted at a clinical research center.Patients or Other Participants:Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.Intervention:Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am.Main Outcome Measure:Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).Results:Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).Conclusions:Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.CONTEXTPuberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.OBJECTIVEThe objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.This was a cross-sectional analysis.DESIGNThis was a cross-sectional analysis.The study was conducted at a clinical research center.SETTINGThe study was conducted at a clinical research center.Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.PATIENTS OR OTHER PARTICIPANTSTwenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am.INTERVENTIONBlood samples were taken every 10 minutes from 7:00 pm to 7:00 am.Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).MAIN OUTCOME MEASUREChange in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).RESULTSBoth nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.CONCLUSIONSDay-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
CONTEXT:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown. OBJECTIVE:The objective of the study was to test two hypotheses1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia. DESIGN:This was a cross-sectional analysis. SETTING:The study was conducted at a clinical research center. PATIENTS OR OTHER PARTICIPANTS:Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study. INTERVENTION:Blood samples were taken every 10 minutes from 7:00 PM to 7:00 AM. MAIN OUTCOME MEASURE:Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 PM-11:00 PM, while awake) to nighttime hours (11:00 PM to 7:00 AM, while generally asleep). RESULTS:Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively). CONCLUSIONS:Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
Author Patrie, James T.
Chang, R. Jeffrey
McCartney, Christopher R.
Burt Solorzano, Christine
Beller, Jennifer P.
Marshall, John C.
Collins, Jessicah S.
AuthorAffiliation The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.) and Pediatrics (C.B.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia Health System, Charlottesville, Virginia 22908; and Division of Reproductive Endocrinology and Infertility (R.J.C.), Department of Reproductive Medicine, University of California, San Diego, San Diego, California 92103
AuthorAffiliation_xml – name: The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.) and Pediatrics (C.B.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia Health System, Charlottesville, Virginia 22908; and Division of Reproductive Endocrinology and Infertility (R.J.C.), Department of Reproductive Medicine, University of California, San Diego, San Diego, California 92103
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  givenname: Jessicah S.
  surname: Collins
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  givenname: Jennifer P.
  surname: Beller
  fullname: Beller, Jennifer P.
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  givenname: John C.
  surname: Marshall
  fullname: Marshall, John C.
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  givenname: Christopher R.
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  organization: 1The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908
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Issue 8
Keywords Endocrinopathy
Human
Obesity
Night
Nutrition
Nutrition disorder
Metabolic diseases
Gonadotropin
Change
Adenohypophyseal hormone
Blunted effect
Luteinizing hormone
Female
Frequency
Hyperandrogenism
Child
Endocrinology
Nutritional status
Language English
License CC BY 4.0
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PublicationDate 2014-August
PublicationDateYYYYMMDD 2014-08-01
PublicationDate_xml – month: 08
  year: 2014
  text: 2014-August
PublicationDecade 2010
PublicationPlace Bethesda, MD
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PublicationTitle The journal of clinical endocrinology and metabolism
PublicationTitleAlternate J Clin Endocrinol Metab
PublicationYear 2014
Publisher Oxford University Press
Copyright by The Endocrine Society
Endocrine Society
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Snippet Context:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night...
CONTEXT:Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night...
Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH...
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crossref
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StartPage 2887
SubjectTerms Adolescent
Biological and medical sciences
Child
Circadian Rhythm
Cross-Sectional Studies
Endocrine Research
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Girls
Humans
Hyperandrogenism - blood
Luteinizing hormone
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Medical sciences
Menarche - blood
Obesity
Obesity - blood
Puberty
Puberty - blood
Secretion
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Title Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia
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https://www.ncbi.nlm.nih.gov/pubmed/24780043
https://www.proquest.com/docview/3164472032
https://www.proquest.com/docview/1552367813
https://pubmed.ncbi.nlm.nih.gov/PMC4121026
Volume 99
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