A guide to chemokines and their receptors

• Published in: The FEBS journal Vol. 285; no. 16; pp. 2944 - 2971
• Main Authors: Hughes, Catherine E., Nibbs, Robert J. B.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2018; John Wiley and Sons Inc
• Subjects: A Guide to; Animals; atypical chemokine receptor; Blood cells; cell migration; Cell Movement; Cell surface; chemokine; chemokine receptor; Chemokine receptors; Chemokines; Chemokines - genetics; Chemokines - metabolism; Chemokinesis; Chemotaxis; Cytokines; Extracellular matrix; glycosaminoglycan; Glycosaminoglycans - metabolism; Homeostasis; Host-Pathogen Interactions - physiology; Humans; immune surveillance; Immune system; Infections - etiology; Inflammation; Inflammation - etiology; leukocyte; Leukocyte migration; Leukocytes; Localization; oligomerization; post-translational modification; protease; Protein Multimerization; Protein Processing, Post-Translational; Proteins; Receptors; Receptors, Chemokine - genetics; Receptors, Chemokine - metabolism; atypical chemokine receptor; protease; chemokine; oligomerization; inflammation; leukocyte; cell migration; glycosaminoglycan; chemokine receptor; immune surveillance

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). Conseq...