G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study

The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET–melting experiments and equilibrium microdialysis...

Full description

Saved in:

Bibliographic Details
Published in	ChemMedChem Vol. 2; no. 5; pp. 655 - 666
Main Authors	Hounsou, Candide, Guittat, Lionel, Monchaud, David, Jourdan, Muriel, Saettel, Nicolas, Mergny, Jean-Louis, Teulade-Fichou, Marie-Paule
Format	Journal Article
Language	English
Published	Weinheim WILEY-VCH Verlag 14.05.2007 WILEY‐VCH Verlag Wiley-VCH Verlag
Subjects	Acridines - chemistry Chemical Sciences DNA structures electrostatic interactions Fluorescence Resonance Energy Transfer Magnetic Resonance Spectroscopy NMR spectroscopy Organic chemistry quinacridines stacking interactions Structure-Activity Relationship
Online Access	Get full text

Cover

Loading…

Abstract	The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET–melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G‐quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex‐interactive compounds for use in anticancer approaches. The synthesis and evaluation of G‐quadruplex binding properties of a series of quinacridine‐based ligands (MMQs) are described. Structure–activity relationship studies support a model of interaction of these compounds with G‐quadruplex structures which is furthermore confirmed by the solution structure determined by 2D NMR experiments.
AbstractList	The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches. The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET–melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G‐quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex‐interactive compounds for use in anticancer approaches. The synthesis and evaluation of G‐quadruplex binding properties of a series of quinacridine‐based ligands (MMQs) are described. Structure–activity relationship studies support a model of interaction of these compounds with G‐quadruplex structures which is furthermore confirmed by the solution structure determined by 2D NMR experiments. Abstract The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET–melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G‐quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex‐interactive compounds for use in anticancer approaches.
Author	Saettel, Nicolas Hounsou, Candide Mergny, Jean-Louis Teulade-Fichou, Marie-Paule Jourdan, Muriel Guittat, Lionel Monchaud, David
Author_xml	– sequence: 1 givenname: Candide surname: Hounsou fullname: Hounsou, Candide organization: Laboratoire de Chimie des Interactions Moléculaires, CNRS UPR 285, Collège de France, 11, place Marcellin Berthelot, 75005 Paris, France – sequence: 2 givenname: Lionel surname: Guittat fullname: Guittat, Lionel organization: Laboratoire de Biophysique, INSERM U565 CNRS UMR 5153, Muséum National d'Histoire Naturelle, USM503, 43, rue Cuvier, 75005 Paris, France – sequence: 3 givenname: David surname: Monchaud fullname: Monchaud, David organization: Laboratoire de Chimie des Interactions Moléculaires, CNRS UPR 285, Collège de France, 11, place Marcellin Berthelot, 75005 Paris, France – sequence: 4 givenname: Muriel surname: Jourdan fullname: Jourdan, Muriel organization: Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS, 301 rue de la Chimie, Bat. Chimie Recherche, 38041 Grenoble, Cedex 9, France – sequence: 5 givenname: Nicolas surname: Saettel fullname: Saettel, Nicolas organization: Laboratoire de Chimie des Interactions Moléculaires, CNRS UPR 285, Collège de France, 11, place Marcellin Berthelot, 75005 Paris, France – sequence: 6 givenname: Jean-Louis surname: Mergny fullname: Mergny, Jean-Louis organization: Laboratoire de Biophysique, INSERM U565 CNRS UMR 5153, Muséum National d'Histoire Naturelle, USM503, 43, rue Cuvier, 75005 Paris, France – sequence: 7 givenname: Marie-Paule surname: Teulade-Fichou fullname: Teulade-Fichou, Marie-Paule email: marie-paule.teulade-fichou@curie.fr organization: Laboratoire de Chimie des Interactions Moléculaires, CNRS UPR 285, Collège de France, 11, place Marcellin Berthelot, 75005 Paris, France
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17385760$$D View this record in MEDLINE/PubMed https://hal.science/hal-00258167$$DView record in HAL
BookMark	eNqFkM1PwjAYhxujUUGvHs1OJiYO2279mDdERSNgwA-8NV3XaXWsuDKV_94tI-jNS9u3eX7Pm_xaYDO3uQbgAMEOghCfqlmiOhhCWg2cboBdxCn0GeJsc_1m0Q5oOfcGYRhyxLfBDmIBJ4zCXXDb98elTIpynulvb6KVfcnNwtjci5feuDS5VIVJTK7dmSe9--7kxBsNq0PmiXdubGZfjJKZd78ok-Ue2Epl5vT-6m6Dx6vLh961P7jr3_S6A19V66nPoUpwxHGcaIJkSKBCKaMa8hQhjAmnMU0RlpxTxBiPKY4iFfMI4pikNIiDoA2OG--rzMS8MDNZLIWVRlx3B6L-q7og1Sb2iSr2qGHnhf0otVuImXFKZ5nMtS2dYDCkhEe1tNOAqrDOFTpdmxEUddWirlqsq64ChytzGc908ouvuq2AqAG-TKaX_-hEb3jR-yv3m6xxC_29zsriXVAWMCKmo7544s9k9DRFIgh-AM27l_8
CitedBy_id	crossref_primary_10_1021_ja310056y crossref_primary_10_4155_fso_15_93 crossref_primary_10_1021_jp106683n crossref_primary_10_1002_chem_201203461 crossref_primary_10_1002_anie_201308063 crossref_primary_10_1002_cbic_200800330 crossref_primary_10_1002_biot_201600531 crossref_primary_10_1002_cmdc_201600053 crossref_primary_10_1021_bi1017304 crossref_primary_10_1007_s41745_018_0083_3 crossref_primary_10_1002_ange_200800468 crossref_primary_10_1002_chem_200903456 crossref_primary_10_1007_s00044_014_0985_1 crossref_primary_10_1002_cbic_200800062 crossref_primary_10_1039_b912716j crossref_primary_10_1021_bi201600g crossref_primary_10_1021_bi9020583 crossref_primary_10_1039_D0DT02125C crossref_primary_10_1093_nar_gkv425 crossref_primary_10_1002_chem_201002810 crossref_primary_10_1002_ejoc_200801196 crossref_primary_10_1016_j_bmcl_2013_10_030 crossref_primary_10_3390_molecules181113588 crossref_primary_10_1080_15257770701548212 crossref_primary_10_1111_j_1742_4658_2009_07461_x crossref_primary_10_3389_fchem_2020_00060 crossref_primary_10_3390_molecules27092791 crossref_primary_10_1002_chem_201504351 crossref_primary_10_1021_acs_jcim_6b00473 crossref_primary_10_4061_2010_525862 crossref_primary_10_1016_j_biochi_2011_05_022 crossref_primary_10_1002_chem_201700417 crossref_primary_10_3390_pharmaceutics14112361 crossref_primary_10_1039_C8CC03945C crossref_primary_10_5802_crchim_256 crossref_primary_10_1134_S0026893314060077 crossref_primary_10_1002_ejoc_201900401 crossref_primary_10_1039_c1cs15117g crossref_primary_10_1016_j_ymeth_2012_05_003 crossref_primary_10_1002_anie_201606877 crossref_primary_10_3390_ph15030300 crossref_primary_10_1002_ange_200906363 crossref_primary_10_1039_C6CP01121G crossref_primary_10_1016_j_saa_2018_02_051 crossref_primary_10_1039_D2CP00214K crossref_primary_10_1093_nar_gkn487 crossref_primary_10_1002_anie_200906363 crossref_primary_10_1002_cmdc_201000332 crossref_primary_10_4061_2010_460561 crossref_primary_10_1016_j_tet_2016_01_022 crossref_primary_10_1007_s00775_007_0273_3 crossref_primary_10_1016_j_bpj_2011_01_068 crossref_primary_10_1039_b708635k crossref_primary_10_1002_ange_201606877 crossref_primary_10_1093_nar_gkn517 crossref_primary_10_1371_journal_pone_0072462 crossref_primary_10_1007_s10593_017_2055_3 crossref_primary_10_3390_ph15050548 crossref_primary_10_1021_ac300207r crossref_primary_10_1371_journal_pone_0057701 crossref_primary_10_1021_ja405843r crossref_primary_10_1016_j_saa_2018_12_044 crossref_primary_10_1021_ol402732n crossref_primary_10_1146_annurev_biophys_060320_091827 crossref_primary_10_1039_c0cs00134a crossref_primary_10_1111_cbdd_13910 crossref_primary_10_1039_D2CP02241A crossref_primary_10_1002_chem_201103019 crossref_primary_10_1039_B714772B crossref_primary_10_1002_chem_201500347 crossref_primary_10_1371_journal_pone_0031201 crossref_primary_10_1002_bip_22660 crossref_primary_10_1007_s00216_011_5018_z crossref_primary_10_3390_molecules24030396 crossref_primary_10_1021_ic100884p crossref_primary_10_1002_anie_200800468 crossref_primary_10_1016_j_ejmech_2014_11_021 crossref_primary_10_1039_c1cs15067g crossref_primary_10_3389_fgene_2021_632359 crossref_primary_10_1039_c1ob05884c crossref_primary_10_1021_bi101517e crossref_primary_10_1021_ic8016547 crossref_primary_10_1021_jacs_8b09329 crossref_primary_10_1007_s10822_012_9619_1 crossref_primary_10_1016_j_sbi_2010_03_001 crossref_primary_10_1002_chem_202101866 crossref_primary_10_1039_C5RA17390F crossref_primary_10_1021_bi1001773 crossref_primary_10_1016_j_ijbiomac_2015_03_034 crossref_primary_10_1016_j_biochi_2017_11_004 crossref_primary_10_1021_acsomega_8b01574 crossref_primary_10_1016_j_biochi_2008_02_019 crossref_primary_10_1002_ange_201308063 crossref_primary_10_3390_cells9020359 crossref_primary_10_1038_s41419_023_05562_0 crossref_primary_10_1039_D0DT01527J crossref_primary_10_3390_molecules27051541
Cites_doi	10.1093/nar/gkl655 10.1074/jbc.M308440200 10.1016/j.bmcl.2006.06.067 10.1038/nrc1587 10.1021/bi981330n 10.1021/ja0297988 10.1021/bi992070s 10.1016/S0022-2836(02)01354-2 10.1038/nrc749 10.1016/S0092-8674(01)00566-9 10.1021/bi049697h 10.1002/1439-7633(20010202)2:2<124::AID-CBIC124>3.0.CO;2-L 10.1073/pnas.051620698 10.1021/ja062193h 10.1126/science.7605428 10.1021/ja021299j 10.1016/0022-1759(83)90303-4 10.1158/0008-5472.CAN-06-1581 10.1021/bi034531m 10.1158/0008-5472.CAN-04-2910 10.1002/prot.340110407 10.1016/j.tetlet.2005.02.079 10.1038/nchembio723 10.1038/sj.onc.1208468 10.1002/1521-3757(20011217)113:24<4885::AID-ANGE4885>3.0.CO;2-3 10.1093/nar/gkl529 10.1038/nrd793 10.1002/ange.200300589 10.1073/pnas.141229498 10.1016/j.bmcl.2004.05.090 10.1016/S0959-8049(97)00062-2 10.1021/ja00780a030 10.1074/jbc.M409293200 10.1021/jo00819a003 10.1093/nar/gkg392 10.1016/0301-4622(84)87006-4 10.1016/j.bpc.2006.06.006 10.1021/jm0308693 10.1093/nass/49.1.235 10.1101/gad.1200804 10.1093/nar/gki514 10.1021/jo970496b 10.1002/anie.200300589 10.1016/j.jmb.2003.09.018 10.1038/nsmb982 10.1021/ic50042a021 10.1039/b516378a 10.1021/bi00434a017 10.1016/j.sbi.2006.05.011 10.1074/jbc.M605828200 10.1002/jcc.540070216 10.1021/bi0263107 10.1146/annurev.pharmtox.43.100901.135733 10.1038/35040500 10.1016/S0959-440X(03)00072-1 10.1021/jm050555a 10.1021/j100825a031 10.1093/nar/gki722 10.1146/annurev.biochem.73.071403.160049 10.1002/1521-3773(20011217)40:24<4749::AID-ANIE4749>3.0.CO;2-I
ContentType	Journal Article
Copyright	Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim – notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID	BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 1XC
DOI	10.1002/cmdc.200600286
DatabaseName	Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Hyper Article en Ligne (HAL)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE CrossRef
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Pharmacy, Therapeutics, & Pharmacology
EISSN	1860-7187
EndPage	666
ExternalDocumentID	oai_HAL_hal_00258167v1 10_1002_cmdc_200600286 17385760 CMDC200600286 ark_67375_WNG_V8X5NVW1_3
Genre	article Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: ARC funderid: 3365 – fundername: E.U. FP6 “MolCancerMed” funderid: LSHC-CT-2004-502943 – fundername: Ligue Nationale Contre le Cancer
GroupedDBID	--- 05W 0R~ 1L6 1OC 29B 33P 3WU 4.4 53G 5GY 66C 6J9 77Q 8-0 8-1 A00 AAESR AAHHS AAJUZ AANLZ AASGY AAXRX AAZKR ABCUV ABCVL ABHUG ABIJN ABJNI ABLJU ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACPRK ACXBN ACXQS ADBBV ADDAD ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFRAH AGJLS AHBTC AHMBA AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB ASPBG AVWKF AZFZN AZVAB BDRZF BFHJK BMXJE BRXPI BSCLL CS3 DCZOG DR2 DRFUL DRSTM DU5 EBS EJD F5P FEDTE G-S GODZA HBH HF~ HHZ HVGLF HZ~ IX1 LATKE LAW LEEKS LH4 LITHE LOXES LUTES LW6 LYRES MEWTI MXFUL MXSTM MY~ O9- P2W P4E PQQKQ ROL RWI SUPJJ W99 WBKPD WXSBR WYJ XV2 YZZ ZZTAW ~S- AITYG HGLYW OIG 31~ AFFNX CGR CUY CVF EBD ECM EIF EMOBN NPM SV3 WOHZO AAYXX CITATION 7X8 1XC
ID	FETCH-LOGICAL-c4816-80cd2982bde51a450c1f76e08f1122586b6f12a8861778b6299cb8902b5f63b33
IEDL.DBID	DR2
ISSN	1860-7179
IngestDate	Tue Oct 15 15:40:43 EDT 2024 Fri Aug 16 23:44:13 EDT 2024 Fri Aug 23 01:11:54 EDT 2024 Sat Sep 28 07:44:46 EDT 2024 Sat Aug 24 00:54:46 EDT 2024 Wed Jan 17 05:05:46 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
License	Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4816-80cd2982bde51a450c1f76e08f1122586b6f12a8861778b6299cb8902b5f63b33
Notes	istex:0F2928F0D76A1866049D6F51A8728DF62A8D4402 ark:/67375/WNG-V8X5NVW1-3 E.U. FP6 "MolCancerMed" - No. LSHC-CT-2004-502943 Ligue Nationale Contre le Cancer ArticleID:CMDC200600286 ARC - No. 3365 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	17385760
PQID	70465893
PQPubID	23479
PageCount	12
ParticipantIDs	hal_primary_oai_HAL_hal_00258167v1 proquest_miscellaneous_70465893 crossref_primary_10_1002_cmdc_200600286 pubmed_primary_17385760 wiley_primary_10_1002_cmdc_200600286_CMDC200600286 istex_primary_ark_67375_WNG_V8X5NVW1_3
PublicationCentury	2000
PublicationDate	May 14, 2007
PublicationDateYYYYMMDD	2007-05-14
PublicationDate_xml	– month: 05 year: 2007 text: May 14, 2007 day: 14
PublicationDecade	2000
PublicationPlace	Weinheim
PublicationPlace_xml	– name: Weinheim – name: Germany
PublicationTitle	ChemMedChem
PublicationTitleAlternate	ChemMedChem
PublicationYear	2007
Publisher	WILEY-VCH Verlag WILEY‐VCH Verlag Wiley-VCH Verlag
Publisher_xml	– name: WILEY-VCH Verlag – name: WILEY‐VCH Verlag – name: Wiley-VCH Verlag
References	J.-L. Mergny, L. Lacroix, M.-P. Teulade-Fichou, C. Hounsou, L. Guittat, M. Hoarau, P. B. Arimondo, J.-P. Vigneron, J.-M. Lehn, J.-F. Riou, T. Garestier, C. Hélène, Proc. Natl. Acad. Sci. USA 2001, 98, 3062 A. Smogorzewska, T. de Lange, Annu. Rev. Biochem. 2004, 73, 177. L. H. Hurley, Nat. Rev. Cancer 2002, 2, 188 S. Neidle, G. Parkinson, Nat. Rev. Drug Discovery 2002, 1, 383 G. Pennarun, C. Granotier, L. R. Gauthier, D. Gomez, F. Hoffschir, E. Mandine, J.-F. Riou, J.-L. Mergny, P. Mailliet, F. Boussin, Oncogene 2005, 24, 2917 S. Neidle, D. E. Thurston, Nat. Rev. Cancer 2005, 5, 285. E. Gavathiotis, R. A. Heald, M. F. G. Stevens, M. S. Searle, Angew. Chem. 2001, 113, 4885 R. J. Harrison, J. Cuesta, G. Chessari, M. Read, S. K. Basra, A. P. Reszka, J. Morrell, S. M. Gowan, C. M. Incles, F. A. Tanious, W. D. Wilson, L. R. Kelland, S. Neidle, J. Med. Chem. 2003, 46, 4463 J. Ren, J. B. Chaires, Biochemistry 1999, 38, 16067 J. W. Shay, S. Bachetti, Eur. J. Cancer 1997, 33, 787. D. Monchaud, C. Allain, M.-P. Teulade-Fichou, Bioorg. Med. Chem. Lett. 2006, 16, 4842. M. I. Page, W. P. Jencks, J. Am. Chem. Soc. 1972, 94, 8818. J.-L. Mergny, J.-C. Maurizot, ChemBioChem 2001, 2, 124 M.-P. Teulade-Fichou, C. Carrasco, L. Guittat, C. Bailly, P. Alberti, J.-L. Mergny, A. David, J.-M. Lehn, W. D. Wilson, J. Am. Chem. Soc. 2003, 125, 4732 F. Rosu, E. De Pauw, L. Guittat, P. Alberti, L. Lacroix, P. Mailliet, J.-F. Riou, J.-L. Mergny, Biochemistry 2003, 42, 10361. R. Lartia, H. Bertrand, M.-P. Teulade-Fichou, Synlett 2006, 610 J. Hine, F. Via, J. H. Hensen, J. Org. Chem. 1971, 36, 2926 D. Liu, M. S. O'Connor, J. Qin, Z. Songyang, J. Biol. Chem. 2004, 279, 51338 M. J. B. Moore, C. M. Schultes, J. Cuesta, F. Cuenca, M. Gunaratnam, F. A. Tanious, W. D. Wilson, S. Neidle, J. Med. Chem. 2006, 49, 582. D. Gomez, N. Aouali, A. Londono-Vallejo, L. Lacroix, F. Mégnin-Chanet, T. Lemarteleur, C. Douarre, K. Shin-ya, P. Mailliet, C. Trentesaux, H. Morjani, J.-L. Mergny, J.-F. Riou, J. Biol. Chem. 2003, 278, 50554 O. Y. Fedoroff, M. Salazar, H. Han, V. V. Chemeris, S. M. Kerwin, L. H. Hurley, Biochemistry 1998, 37, 12367 C. Allain, D. Monchaud, M.-P. Teulade-Fichou, J. Am. Chem. Soc. 2006, 128, 11890. E. W. White, F. Tanious, M. A. Ismail, A. P. Reszka, S. Neidle, D. W. Boykin, W. D. Wilson, Biophys. Chem. 2007, 126, 140. C. M. Schultes, B. Guyen, J. Cuesta, S. Neidle, Bioorg. Med. Chem. Lett. 2004, 14, 4347 T. Mosmann, J. Immunol. Methods 1983, 65, 55. S. J. Weiner, P. A. Kollman, D. T. Nguyen, D. A. Case, J. Comput. Chem. 1986, 7, 230. E. H. Blackburn, Nature 2000, 408, 53 A. De Cian, L. Guittat, K. Shin-ya, J.-F. Riou, J.-L. Mergny, Nucleic Acids Symp. Ser. 2005, 49, 235. N. W. Kim, M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Corviello, W. E. Wright, S. L. Weinrich, J. W. Shay, Science 1994, 266, 2011 K. Paeschke, T. Simonsson, J. Postberg, D. Rhodes, H. J. Lipps, Nat. Struct. Mol. Biol. 2005, 12, 847 J. C. Darnell, K. B. Jensen, P. Jin, V. Brown, S. T. Warren, R. B. Darnell, Cell 2001, 107, 489 O. Baudoin, M.-P. Teulade-Fichou, J.-P. Vigneron, J.-M. Lehn, J. Org. Chem. 1997, 62, 5458 F. Onasch, D. Aikens, S. Bunce, H. Schwartz, D. Nairn, C. Hurwitz, Biophys. Chem. 1984, 19, 245 E. M. Rezler, D. J. Bearss, L. H. Hurley, Annu. Rev. Pharmacol. Toxicol. 2003, 43, 359 S. Neidle, G. N. Parkinson, Curr. Opin. Struct. Biol. 2003, 13, 275. A. Vacca, D. Arenare, P. Paoletti, Inorg. Chem. 1966, 5, 1384 M. Ciampolini, P. Paoletti, J. Phys. Chem. 1961, 65, 1224 M. L. Duquette, P. Handa, J. A. Vincent, A. F. Taylor, N. Maizels, Gen. Dev. 2004, 18, 1618 C. Granotier, G. Pennarun, L. Riou, F. Hoffschir, L. R. Gauthier, A. De Cian, D. Gomez, E. Mandine, J.-F. Riou, J.-L. Mergny, P. Mailliet, B. Dutrillaux, F. D. Boussin, Nucleic Acids Res. 2005, 33, 4182 A. Slama-Schwok, J. Jazwinski, A. Béré, T. Montenay-Garestier, M. Rougée, C. Hélène, J.-M. Lehn, Biochemistry 1989, 28, 3227. Angew. Chem. Int. Ed. 2001, 40, 4749 D. Gomez, M.-F. O'Donohue, T. Wenner, C. Douarre, J. Macadre, P. Koebel, M. J. Giraud-Panis, H. Kaplan, A. Kolkes, K. Shin-ya, J.-F. Riou, Cancer Res. 2006, 66, 6908 A. Nicholls, K. A. Sharp, B. Honig, Proteins Struct. Funct. Genet. 1991, 11, 281. M. Kaiser, A. De Cian, M. Sainlos, C. Renner, J.-L. Mergny, M.-P. Teulade-Fichou, Org. Biomol. Chem. 2006, 4, 1049. J. T. Kern, P. W. Thomas, S. M. Kerwin, Biochemistry 2002, 41, 11379 M. J. Cocco, L. A. Hanakahi, M. D. Huber, N. Maizels, Nucleic Acids Res. 2003, 31, 2944. C. Schaffitzel, I. Berger, J. Postberg, J. Hanes, H. J. Lipps, A. Pluckthun, Proc. Natl. Acad. Sci. USA 2001, 98, 8572 J. Eddy, N. Maizels, Nucleic Acids Res. 2006, 34, 3887. C. Douarre, D. Gomez, H. Morjani, J.-M. Zahm, M.-F. O'Donohue, L. Eddabra, P. Mailliet, J.-F. Riou, C. Trentesaux, Nucleic Acids Res. 2005, 33, 2192 A. K. Mehta, Y. Shayo, H. Vankayalapati, L. H. Hurley, J. Schaefer, Biochemistry 2004, 43, 11953. E. Gavathiotis, R. A. Heald, M. F. G. Stevens, M. S. Searle, J. Mol. Biol. 2003, 334, 25 C. Jacquelin, N. Saettel, C. Hounsou, M.-P. Teulade-Fichou, Tetrahedron Lett. 2005, 46, 2589. W. Duan, A. Rangan, H. Vankayalapati, M.-Y. Kim, Q. Zeng, D. Sun, H. Han, O. Y. Fedoroff, D. Nishioka, S. Y. Rha, E. Izbicka, D. D. Von Hoff, L. H. Hurley, Mol. Cancer Ther. 2001, 1, 103 A. T. Phan, V. Kuryavyi, H. Y. Gaw, D. Patel, Nat. Chem. Biol. 2005, 1, 167. J. T. Davis, Angew. Chem. 2004, 116, 684 S. Burge, G. N. Parkinson, P. Hazel, A. K. Todd, S. Neidle, Nucleic Acids Res. 2006, 34, 5402 Angew. Chem. Int. Ed. 2004, 43, 668. S. M. Haider, G. N. Parkinson, S. Neidle, J. Mol. Biol. 2003, 326, 117. G. R. Clark, P. D. Pytel, C. J. Squire, S. Neidle, J. Am. Chem. Soc. 2003, 125, 4066. D. Gomez, T. Wenner, B. Brassart, C. Douarre, M.-F. O'Donohue, V. El Khoury, K. Shin-ya, H. Morjani, C. Trentesaux, J.-F. Riou, J. Biol. Chem. 2006, 281, 38721. A. T. Phan, V. Kuryavyi, D. J. Patel, Curr. Opin. Struct. Biol. 2006, 16, 288 A. M. Burger, F. Dai, C. M. Schultes, A. P. Reszka, M. J. B. Moore, J. A. Double, S. Neidle, Cancer Res. 2005, 65, 1489 2006; 34 1991; 11 2003; 13 2005; 65 2001; 107 2003; 278 2005; 24 1994; 266 2000; 408 2004; 73 2003; 326 2002; 41 1986; 7 2006; 66 2001 2001; 113 40 1972; 94 2003; 46 1983; 65 1984; 19 2006; 281 2003; 125 2006; 128 2005; 33 2003; 42 2003; 43 2001; 98 2004; 43 2007; 126 2004 2004; 116 43 1997; 62 2006; 16 1966; 5 2002; 1 2002; 2 2006 2006; 4 2003; 334 2005; 49 2003; 31 1989; 28 2005; 46 1998; 37 2004; 279 1997; 33 2004; 18 2004; 14 2006; 49 1999; 38 1971; 36 2005; 5 2005; 1 2001; 2 2001; 1 1961; 65 2005; 12 e_1_2_7_5_2 e_1_2_7_3_2 e_1_2_7_9_2 e_1_2_7_7_2 e_1_2_7_19_2 e_1_2_7_17_2 e_1_2_7_15_2 e_1_2_7_60_2 e_1_2_7_1_2 e_1_2_7_13_2 e_1_2_7_41_2 e_1_2_7_62_2 e_1_2_7_11_2 e_1_2_7_43_2 e_1_2_7_64_2 e_1_2_7_45_2 e_1_2_7_66_2 e_1_2_7_47_2 e_1_2_7_68_2 e_1_2_7_26_2 e_1_2_7_49_2 e_1_2_7_28_2 e_1_2_7_9_3 e_1_2_7_71_2 e_1_2_7_50_2 e_1_2_7_25_2 e_1_2_7_52_2 e_1_2_7_75_2 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_54_2 e_1_2_7_73_2 e_1_2_7_21_2 e_1_2_7_33_2 e_1_2_7_56_2 Duan W. (e_1_2_7_58_2) 2001; 1 e_1_2_7_37_2 e_1_2_7_39_2 e_1_2_7_4_2 e_1_2_7_2_2 e_1_2_7_8_2 e_1_2_7_6_2 e_1_2_7_18_2 e_1_2_7_16_2 e_1_2_7_61_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_63_2 e_1_2_7_12_2 e_1_2_7_42_2 e_1_2_7_65_2 e_1_2_7_10_2 Lartia R. (e_1_2_7_35_2) 2006 e_1_2_7_44_2 e_1_2_7_67_2 e_1_2_7_46_2 e_1_2_7_69_2 e_1_2_7_48_2 e_1_2_7_27_2 e_1_2_7_29_2 e_1_2_7_72_2 e_1_2_7_70_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_51_2 e_1_2_7_53_3 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_53_2 e_1_2_7_74_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_55_2 e_1_2_7_36_2 e_1_2_7_57_2 e_1_2_7_38_2 e_1_2_7_59_2
References_xml	– volume: 266 start-page: 2011 year: 1994 publication-title: Science – volume: 43 start-page: 359 year: 2003 publication-title: Annu. Rev. Pharmacol. Toxicol. – volume: 326 start-page: 117 year: 2003 publication-title: J. Mol. Biol. – volume: 98 start-page: 8572 year: 2001 publication-title: Proc. Natl. Acad. Sci. USA – volume: 125 start-page: 4732 year: 2003 publication-title: J. Am. Chem. Soc. – volume: 107 start-page: 489 year: 2001 publication-title: Cell – volume: 19 start-page: 245 year: 1984 publication-title: Biophys. Chem. – volume: 16 start-page: 4842 year: 2006 publication-title: Bioorg. Med. Chem. Lett. – volume: 33 start-page: 2192 year: 2005 publication-title: Nucleic Acids Res. – volume: 34 start-page: 3887 year: 2006 publication-title: Nucleic Acids Res. – volume: 28 start-page: 3227 year: 1989 publication-title: Biochemistry – volume: 94 start-page: 8818 year: 1972 publication-title: J. Am. Chem. Soc. – volume: 65 start-page: 1489 year: 2005 publication-title: Cancer Res. – volume: 13 start-page: 275 year: 2003 publication-title: Curr. Opin. Struct. Biol. – volume: 7 start-page: 230 year: 1986 publication-title: J. Comput. Chem. – volume: 279 start-page: 51338 year: 2004 publication-title: J. Biol. Chem. – volume: 281 start-page: 38721 year: 2006 publication-title: J. Biol. Chem. – volume: 1 start-page: 383 year: 2002 publication-title: Nat. Rev. Drug Discovery – volume: 46 start-page: 2589 year: 2005 publication-title: Tetrahedron Lett. – volume: 5 start-page: 285 year: 2005 publication-title: Nat. Rev. Cancer – volume: 113 40 start-page: 4885 4749 year: 2001 2001 publication-title: Angew. Chem. Angew. Chem. Int. Ed. – volume: 65 start-page: 55 year: 1983 publication-title: J. Immunol. Methods – volume: 128 start-page: 11890 year: 2006 publication-title: J. Am. Chem. Soc. – volume: 18 start-page: 1618 year: 2004 publication-title: Gen. Dev. – volume: 42 start-page: 10361 year: 2003 publication-title: Biochemistry – volume: 334 start-page: 25 year: 2003 publication-title: J. Mol. Biol. – volume: 46 start-page: 4463 year: 2003 publication-title: J. Med. Chem. – volume: 73 start-page: 177 year: 2004 publication-title: Annu. Rev. Biochem. – volume: 278 start-page: 50554 year: 2003 publication-title: J. Biol. Chem. – volume: 11 start-page: 281 year: 1991 publication-title: Proteins Struct. Funct. Genet. – volume: 98 start-page: 3062 year: 2001 publication-title: Proc. Natl. Acad. Sci. USA – volume: 41 start-page: 11379 year: 2002 publication-title: Biochemistry – volume: 31 start-page: 2944 year: 2003 publication-title: Nucleic Acids Res. – volume: 1 start-page: 103 year: 2001 publication-title: Mol. Cancer Ther. – volume: 34 start-page: 5402 year: 2006 publication-title: Nucleic Acids Res. – volume: 49 start-page: 235 year: 2005 publication-title: Nucleic Acids Symp. Ser. – volume: 62 start-page: 5458 year: 1997 publication-title: J. Org. Chem. – volume: 33 start-page: 4182 year: 2005 publication-title: Nucleic Acids Res. – volume: 12 start-page: 847 year: 2005 publication-title: Nat. Struct. Mol. Biol. – volume: 4 start-page: 1049 year: 2006 publication-title: Org. Biomol. Chem. – start-page: 610 year: 2006 publication-title: Synlett – volume: 408 start-page: 53 year: 2000 publication-title: Nature – volume: 37 start-page: 12367 year: 1998 publication-title: Biochemistry – volume: 49 start-page: 582 year: 2006 publication-title: J. Med. Chem. – volume: 38 start-page: 16067 year: 1999 publication-title: Biochemistry – volume: 2 start-page: 124 year: 2001 publication-title: ChemBioChem – volume: 16 start-page: 288 year: 2006 publication-title: Curr. Opin. Struct. Biol. – volume: 33 start-page: 787 year: 1997 publication-title: Eur. J. Cancer – volume: 5 start-page: 1384 year: 1966 publication-title: Inorg. Chem. – volume: 43 start-page: 11953 year: 2004 publication-title: Biochemistry – volume: 1 start-page: 167 year: 2005 publication-title: Nat. Chem. Biol. – volume: 126 start-page: 140 year: 2007 publication-title: Biophys. Chem. – volume: 125 start-page: 4066 year: 2003 publication-title: J. Am. Chem. Soc. – volume: 66 start-page: 6908 year: 2006 publication-title: Cancer Res. – volume: 24 start-page: 2917 year: 2005 publication-title: Oncogene – volume: 65 start-page: 1224 year: 1961 publication-title: J. Phys. Chem. – volume: 36 start-page: 2926 year: 1971 publication-title: J. Org. Chem. – volume: 2 start-page: 188 year: 2002 publication-title: Nat. Rev. Cancer – volume: 14 start-page: 4347 year: 2004 publication-title: Bioorg. Med. Chem. Lett. – volume: 116 43 start-page: 684 668 year: 2004 2004 publication-title: Angew. Chem. Angew. Chem. Int. Ed. – ident: e_1_2_7_10_2 – ident: e_1_2_7_7_2 doi: 10.1093/nar/gkl655 – ident: e_1_2_7_11_2 doi: 10.1074/jbc.M308440200 – ident: e_1_2_7_65_2 doi: 10.1016/j.bmcl.2006.06.067 – ident: e_1_2_7_24_2 doi: 10.1038/nrc1587 – ident: e_1_2_7_51_2 doi: 10.1021/bi981330n – ident: e_1_2_7_61_2 doi: 10.1021/ja0297988 – ident: e_1_2_7_63_2 doi: 10.1021/bi992070s – ident: e_1_2_7_31_2 doi: 10.1016/S0022-2836(02)01354-2 – ident: e_1_2_7_21_2 doi: 10.1038/nrc749 – ident: e_1_2_7_50_2 – ident: e_1_2_7_70_2 doi: 10.1016/S0092-8674(01)00566-9 – ident: e_1_2_7_46_2 – ident: e_1_2_7_59_2 doi: 10.1021/bi049697h – ident: e_1_2_7_68_2 – ident: e_1_2_7_38_2 doi: 10.1002/1439-7633(20010202)2:2<124::AID-CBIC124>3.0.CO;2-L – ident: e_1_2_7_34_2 – ident: e_1_2_7_37_2 – ident: e_1_2_7_28_2 doi: 10.1073/pnas.051620698 – ident: e_1_2_7_30_2 doi: 10.1021/ja062193h – ident: e_1_2_7_18_2 doi: 10.1126/science.7605428 – ident: e_1_2_7_29_2 doi: 10.1021/ja021299j – ident: e_1_2_7_62_2 – ident: e_1_2_7_67_2 doi: 10.1016/0022-1759(83)90303-4 – ident: e_1_2_7_15_2 doi: 10.1158/0008-5472.CAN-06-1581 – ident: e_1_2_7_64_2 doi: 10.1021/bi034531m – ident: e_1_2_7_12_2 doi: 10.1158/0008-5472.CAN-04-2910 – ident: e_1_2_7_40_2 – ident: e_1_2_7_60_2 doi: 10.1002/prot.340110407 – ident: e_1_2_7_1_2 – ident: e_1_2_7_36_2 doi: 10.1016/j.tetlet.2005.02.079 – ident: e_1_2_7_56_2 doi: 10.1038/nchembio723 – ident: e_1_2_7_13_2 doi: 10.1038/sj.onc.1208468 – ident: e_1_2_7_53_2 doi: 10.1002/1521-3757(20011217)113:24<4885::AID-ANGE4885>3.0.CO;2-3 – ident: e_1_2_7_74_2 doi: 10.1093/nar/gkl529 – ident: e_1_2_7_22_2 doi: 10.1038/nrd793 – ident: e_1_2_7_9_2 doi: 10.1002/ange.200300589 – ident: e_1_2_7_69_2 doi: 10.1073/pnas.141229498 – ident: e_1_2_7_48_2 doi: 10.1016/j.bmcl.2004.05.090 – ident: e_1_2_7_19_2 doi: 10.1016/S0959-8049(97)00062-2 – ident: e_1_2_7_45_2 doi: 10.1021/ja00780a030 – ident: e_1_2_7_3_2 doi: 10.1074/jbc.M409293200 – ident: e_1_2_7_41_2 doi: 10.1021/jo00819a003 – ident: e_1_2_7_55_2 doi: 10.1093/nar/gkg392 – ident: e_1_2_7_57_2 – ident: e_1_2_7_43_2 doi: 10.1016/0301-4622(84)87006-4 – ident: e_1_2_7_25_2 doi: 10.1016/j.bpc.2006.06.006 – ident: e_1_2_7_47_2 doi: 10.1021/jm0308693 – ident: e_1_2_7_66_2 doi: 10.1093/nass/49.1.235 – ident: e_1_2_7_71_2 doi: 10.1101/gad.1200804 – ident: e_1_2_7_6_2 – ident: e_1_2_7_14_2 doi: 10.1093/nar/gki514 – ident: e_1_2_7_27_2 doi: 10.1021/jo970496b – ident: e_1_2_7_9_3 doi: 10.1002/anie.200300589 – ident: e_1_2_7_26_2 – ident: e_1_2_7_54_2 doi: 10.1016/j.jmb.2003.09.018 – ident: e_1_2_7_72_2 doi: 10.1038/nsmb982 – ident: e_1_2_7_44_2 doi: 10.1021/ic50042a021 – ident: e_1_2_7_20_2 – ident: e_1_2_7_32_2 doi: 10.1039/b516378a – start-page: 610 year: 2006 ident: e_1_2_7_35_2 publication-title: Synlett contributor: fullname: Lartia R. – ident: e_1_2_7_33_2 doi: 10.1021/bi00434a017 – ident: e_1_2_7_8_2 doi: 10.1016/j.sbi.2006.05.011 – ident: e_1_2_7_16_2 doi: 10.1074/jbc.M605828200 – ident: e_1_2_7_75_2 doi: 10.1002/jcc.540070216 – ident: e_1_2_7_52_2 doi: 10.1021/bi0263107 – ident: e_1_2_7_23_2 doi: 10.1146/annurev.pharmtox.43.100901.135733 – volume: 1 start-page: 103 year: 2001 ident: e_1_2_7_58_2 publication-title: Mol. Cancer Ther. contributor: fullname: Duan W. – ident: e_1_2_7_2_2 doi: 10.1038/35040500 – ident: e_1_2_7_5_2 doi: 10.1016/S0959-440X(03)00072-1 – ident: e_1_2_7_49_2 doi: 10.1021/jm050555a – ident: e_1_2_7_42_2 doi: 10.1021/j100825a031 – ident: e_1_2_7_73_2 doi: 10.1093/nar/gki722 – ident: e_1_2_7_39_2 – ident: e_1_2_7_17_2 – ident: e_1_2_7_4_2 doi: 10.1146/annurev.biochem.73.071403.160049 – ident: e_1_2_7_53_3 doi: 10.1002/1521-3773(20011217)40:24<4749::AID-ANIE4749>3.0.CO;2-I
SSID	ssj0044818
Score	2.2048678
Snippet	The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of... The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of... Abstract The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A...
SourceID	hal proquest crossref pubmed wiley istex
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	655
SubjectTerms	Acridines - chemistry Chemical Sciences DNA structures electrostatic interactions Fluorescence Resonance Energy Transfer Magnetic Resonance Spectroscopy NMR spectroscopy Organic chemistry quinacridines stacking interactions Structure-Activity Relationship
Title	G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study
URI	https://api.istex.fr/ark:/67375/WNG-V8X5NVW1-3/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcmdc.200600286 https://www.ncbi.nlm.nih.gov/pubmed/17385760 https://search.proquest.com/docview/70465893 https://hal.science/hal-00258167
Volume	2
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1bb9MwFMctGC-8AOO2AAMLofLSbHEutrO3qrBViFZb2aVvlm8RaJBObYNWnvgI-4x8EnziJaUICQleIiWyJcfn2P7bPv4ZoVcJy7W0RRpyamyYssTCRe46TFSeFdTomBk44Dwc0cFJ-m6STX45xe_5EO2CG7SMur-GBi7VfHcFDdVfTI0ghI0lDsxtoOmBKhq3_Cg39agX-AinUejmLXlDbYzi3fXsa6PSzY8QE3kLqvnyT8JzXcfWA9H-XSSbX_DxJ-c71ULt6G-_0R3_5x_voTvXKhX3vFttohu2vI86hx5zvezi49WprXkXd_DhCoC9fICGBz--Xx1V0syqi8_2Eo-bIKVpidUSH1WfSuk6KwMR93tY4g-9cRePhu4hS4P97ZjgOxiCHJcP0cn-2-P-ILy-tiHUrr4Bb6xNnPNYGZsRmWaRJgWjNuKF03ZxxqmiBYkl5048Ma6oGxC1gu1O5bwjUUnyCG2U09JuIWwoMZzSlCrrZnKcSJZam1MnOYhUaWYD9Loxm7jwdA7hOcyxgLoTbd0F6KWzapsIoNqD3nsB30D2uXKzryRAndrobTI5O4fAN5aJs9GBOOWTbHR6RkQSoBeNVwjXHGGPRZZ2Ws0Fi1Kn6XKX4rF3llW5gBvEaBSguDb5Xwos-sM3_fbtyb9keopu-5XoLCTpM7SxmFV220mohXpeN5Ofk5cPRw
link.rule.ids	230,315,786,790,891,1382,27955,27956,46751
linkProvider	Wiley-Blackwell
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLbY9gAv3C_hNguh8tJscRJfwlvVsRVoqq10lzfLjh0xbaRT16CVJ34Cv5Ffgk-ypCpCQoKXSI5syT4X-_Px8WeEXkc8yZTNY18wY_2YRxYecs_8SCc0ZyYLuYELzumIDQ7jDye0ySaEuzA1P0QbcAPPqOZrcHAISG8vWUOzL6biIISTJcHW0IbzeQq-uTNuGaTc5qMK8RHBAt_tXJKGtzEIt1fbr6xLa58hK3IDBH31J-i5imSrpWj3DtLNIOoMlLOtcq63sm-_8Tv-1yjvotvXQBX3asu6h27Y4j7q7NdM14suniwvbl12cQfvLzmwFw9Quvfz-4-DUplZeXFur_C4yVOaFlgv8EF5Wig3XxlIun-LFf7UG3fxKHUfVRhcP5AJ5oMhz3HxEB3uvpv0B_71yw1-5gQODMeZCRMRamMpUTENMpJzZgORO3gXUsE0y0mohHD4iQvN3JqYaTjx1M5AIh1Fj9B6MS3sE4QNI0YwFjNt3WZOEMVjaxPmUAdROqbWQ28avcmLmqBD1lTMoQTZyVZ2Hnrl1NpWAl7tQW8o4R8gP9dv_pV4qFNpva2mZmeQ-8apPB7tySNxQkdHx0RGHtpszEI6j4RjFlXYaXkpeRA7WJe4Go9ra1n2C6iDOAs8FFY6_0uHZT_d6belp__SaBPdHEzSoRy-H318hm7VgWnqk_g5Wp_PSvvCIaq5fln5zC-eAxNn
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=G%E2%80%90Quadruplex+Recognition+by+Quinacridines%3A+a+SAR%2C+NMR%2C+and+Biological+Study&rft.jtitle=ChemMedChem&rft.au=Hounsou%2C+Candide&rft.au=Guittat%2C+Lionel&rft.au=Monchaud%2C+David&rft.au=Jourdan%2C+Muriel&rft.date=2007-05-14&rft.issn=1860-7179&rft.eissn=1860-7187&rft.volume=2&rft.issue=5&rft.spage=655&rft.epage=666&rft_id=info:doi/10.1002%2Fcmdc.200600286&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_cmdc_200600286
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1860-7179&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1860-7179&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1860-7179&client=summon