Organ Weaving: Woven Threads and Sheets As a Step Towards a New Strategy for Artificial Organ Development

• Published in: Macromolecular bioscience Vol. 11; no. 11; pp. 1491 - 1498
• Main Authors: Liberski, Albert R., Delaney Jr, Joseph T., Schäfer, Hendrik, Perelaer, Jolke, Schubert, Ulrich S.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 10.11.2011; WILEY‐VCH Verlag
• Subjects: Alginates - chemistry; Alginates - metabolism; Alginates - pharmacology; Animals; Artificial Organs; Artificial tissues; Biocompatible Materials - chemical synthesis; Biocompatible Materials - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Edetic Acid - chemistry; fibers; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Glucuronic Acid - chemistry; Glucuronic Acid - metabolism; Glucuronic Acid - pharmacology; Hard surfacing; Hexuronic Acids - chemistry; Hexuronic Acids - metabolism; Hexuronic Acids - pharmacology; Humans; hydrogels; matrix; Mice; Organs; Polyesters - chemistry; Strategy; structure; Three dimensional; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Weaving

The concept of “organ weaving” is presented, a fabrication technique that can be an attractive option for the development of artificial tissues and organs. “Living threads” are created by immersing threads that are soaked in a CaCl2 solution into a sodium‐alginate‐loaded cell suspension bath, encaps...