HLA system affects the age‐at‐onset in chronic myeloid leukemia

• Published in: American journal of hematology Vol. 73; no. 4; pp. 256 - 262
• Main Authors: Oguz, Fatma Savran, Kalayoglu, Sevgi, Diler, A. Sarper, Tozkir, Hilmi, Sargin, Deniz, Carin, Mahmut, Dorak, M. Tevfik
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2003; Wiley-Liss
• Subjects: Adolescent; Adult; Age of Onset; Biological and medical sciences; Case-Control Studies; chronic myeloid leukemia; Gene Frequency; Genetic Predisposition to Disease; genetic susceptibility; Hematologic and hematopoietic diseases; HLA Antigens - genetics; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-DR Antigens - genetics; HLA-DRB1 Chains; HLA‐DR; Homozygote; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; major histocompatibility complex; Medical sciences; Middle Aged; Odds Ratio; Retrospective Studies; Turkey - epidemiology; Asia; Turkey; Chromosomal aberration; Human; HLA-System; Major histocompatibility system; Genetic variant; Genotype; Malignant hemopathy; HLA-DR-Locus; Ethnic group; Philadelphia chromosome; Myeloproliferative syndrome; Chronic; Age of onset; Chronic myelocytic leukemia; Predisposition; Abnormal chromosome; Adult; Predictive factor; Age

Chronic myeloid leukemia (CML) occurs from childhood to old age. The adult form is characterized by the presence of Philadelphia chromosome resulting from bcr/abl translocation. The BCR–ABL fusion proteins are immunogenic, and the junctional sequences show unique HLA class I and class II restriction...