Pyroptosis by caspase11/4‐gasdermin‐D pathway in alcoholic hepatitis in mice and patients

• Published in: Hepatology (Baltimore, Md.) Vol. 67; no. 5; pp. 1737 - 1753
• Main Authors: Khanova, Elena, Wu, Raymond, Wang, Wen, Yan, Rui, Chen, Yibu, French, Samuel W., Llorente, Cristina, Pan, Stephanie Q., Yang, Qihong, Li, Yuchang, Lazaro, Raul, Ansong, Charles, Smith, Richard D., Bataller, Ramon, Morgan, Timothy, Schnabl, Bernd, Tsukamoto, Hidekazu
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.05.2018; American Association for the Study of Liver Diseases
• Subjects: Animals; Apoptosis Regulatory Proteins - metabolism; Bacteria; Caspases - metabolism; Caspases, Initiator - metabolism; Cell death; Cytokines - metabolism; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene expression; Gene Expression Profiling - methods; Hepatitis; Hepatitis, Alcoholic - metabolism; Hepatology; Humans; Immunoblotting; Immunoblotting - methods; Inflammasomes; Liver - metabolism; Liver diseases; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins - metabolism; Patients; Pyroptosis; Pyroptosis - genetics; Real-Time Polymerase Chain Reaction; Ribonucleic acid; RNA; Rodents; Signal Transduction; Transcriptome

Alcoholic hepatitis (AH) continues to be a disease with high mortality and no efficacious medical treatment. Although severe AH is presented as acute on chronic liver failure, what underlies this transition from chronic alcoholic steatohepatitis (ASH) to AH is largely unknown. To address this questi...