Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians

• Published in: British journal of clinical pharmacology Vol. 81; no. 6; pp. 1078 - 1090
• Main Authors: Hasunuma, Tomoko, Tohkin, Masahiro, Kaniwa, Nahoko, Jang, In‐Jin, Yimin, Cui, Kaneko, Masaru, Saito, Yoshiro, Takeuchi, Masahiro, Watanabe, Hiroshi, Yamazoe, Yasushi, Uyama, Yoshiaki, Kawai, Shinichi
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.06.2016
• Subjects: Adult; Asian; Asian Continental Ancestry Group - genetics; Cytochrome P-450 CYP2C9 - genetics; difference; ethnic; European Continental Ancestry Group - genetics; extrinsic; Fluoroquinolones - blood; Fluoroquinolones - pharmacokinetics; Fluoroquinolones - urine; Glucuronosyltransferase - genetics; Humans; intrinsic; Liver-Specific Organic Anion Transporter 1 - genetics; Male; Meloxicam; Moxifloxacin; Pharmacokinetics; Polymorphism, Genetic - genetics; Simvastatin - blood; Simvastatin - pharmacokinetics; Thiazines - blood; Thiazines - pharmacokinetics; Thiazoles - blood; Thiazoles - pharmacokinetics; Young Adult; pharmacokinetics; difference; ethnic; extrinsic; intrinsic; Asian

Aim To examine whether strict control of clinical trial conditions could reduce apparent differences of pharmacokinetic (PK) parameters among ethnic groups. Methods Open‐label, single dose PK studies of moxifloxacin, simvastatin and meloxicam were conducted in healthy male subjects from three East A...