Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia

• Published in: Journal of the peripheral nervous system Vol. 20; no. 1; pp. 37 - 46
• Main Authors: Lavoie Smith, Ellen M., Li, Lang, Chiang, ChienWei, Thomas, Karin, Hutchinson, Raymond J., Wells, Elizabeth M., Ho, Richard H., Skiles, Jodi, Chakraborty, Arindom, Bridges, Celia M., Renbarger, Jamie
• Format: Journal Article
• Language: English
• Published: Malden, USA Wiley Periodicals, Inc 01.03.2015; Wiley Subscription Services, Inc
• Subjects: Academic grading; acute lymphoblastic leukemia; Adolescent; Antineoplastic Agents, Phytogenic - adverse effects; Child; Child, Preschool; children; Female; Humans; Infant; Leukemia; Male; Medical treatment; Pain Measurement; patterns; Peripheral Nervous System Diseases - chemically induced; Peripheral Nervous System Diseases - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; severity; Severity of Illness Index; Vincristine - adverse effects; vincristine-induced peripheral neuropathy; severity; vincristine-induced peripheral neuropathy; acute lymphoblastic leukemia; children; patterns

Vincristine, a critical component of combination chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL), can lead to vincristine‐induced peripheral neuropathy (VIPN). Longitudinal VIPN assessments were obtained over 12 months from newly diagnosed children with ALL (N = 128) aged 1–1...