Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

• Published in: The Journal of pathology Vol. 215; no. 2; pp. 155 - 163
• Main Authors: Needham, BE, Wlodek, ME, Ciccotosto, GD, Fam, BC, Masters, CL, Proietto, J, Andrikopoulos, S, Cappai, R
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.06.2008; Wiley
• Subjects: Alzheimer's disease; Amyloid beta-Protein Precursor - analysis; Amyloid beta-Protein Precursor - genetics; amyloid precursor protein; Animals; Biological and medical sciences; Blood Glucose - metabolism; Corticosterone - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Genotype; glucose homeostasis; Growth; Homeostasis; hyperinsulinaaemia; Immunohistochemistry; Insulin - metabolism; Investigative techniques, diagnostic techniques (general aspects); knockout mice; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; postnatal lethality; Pancreatic hormone; Nervous system diseases; Modulator; knockout mice; postnatal lethality; Growth; Alzheimer disease; Homeostasis; Homology; Identification; Glucose; Essential; Insulin; Amyloid precursor protein; Cerebral disorder; glucose homeostasis; Anatomic pathology; Postnatal; Animal; Central nervous system disease; Knockout mouse; hyperinsulinaaemia; Degenerative disease; Alzheimer's disease

The amyloid precursor protein (APP), the source of the neurotoxic amyloid β (Aβ) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of related proteins. In mammals, the APP family contains amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (AP...