Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

• Published in: Immunity, Inflammation and Disease Vol. 11; no. 12; pp. e1112 - n/a
• Main Authors: Roghani, Seyed Askar, Lotfi, Ramin, Soroush, Masood Ghasemzade, Khorasanizadeh, Ali, Feizollahi, Parisa, Assar, Shirin, Soufivand, Parviz, Pournazari, Mehran, Mohammadi Kish, Zahra, Taghadosi, Mahdi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2023; Wiley
• Subjects: anti‐CCP; Biotechnology; Body mass index; CCR6; Chemokines; DAS‐28; Disease; Gene expression; Leukocytes; Ligands; Pathogenesis; Peptides; Plasma; Rheumatoid arthritis; RORγt; Software; Statistical analysis; Thermal cycling; CCR6; anti-CCP; rheumatoid arthritis; DAS-28; RORγt

Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells....