Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity
Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells....
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Published in | Immunity, Inflammation and Disease Vol. 11; no. 12; pp. e1112 - n/a |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.12.2023
Wiley |
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Abstract | Objectives
The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti‐CCP) antibodies and disease activity.
Methods
Forty‐five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real‐time PCR (qRT‐PCR), and anti‐CCP antibodies plasma levels were measured using the enzyme‐linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score‐28 (DAS‐28) formula.
Results
The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS‐28 (p = .006, r = .402), anti‐CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS‐28 (p = .037, r = .310), plasma levels of anti‐CCP (p = .037, r = .312), and ESR (p = .029, r = .327).
Conclusion
Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA.
The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls. Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6, plasma levels of CCL20, ESR, DAS‐28, anti‐CCP, and RF. Also, CCR6 gene expression was positively associated with the DAS‐28, plasma levels of anti‐CCP, and ESR. Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA |
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AbstractList | ObjectivesThe significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor-related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti-CCP) antibodies and disease activity.MethodsForty-five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real-time PCR (qRT-PCR), and anti-CCP antibodies plasma levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score-28 (DAS-28) formula.ResultsThe gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS-28 (p = .006, r = .402), anti-CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS-28 (p = .037, r = .310), plasma levels of anti-CCP (p = .037, r = .312), and ESR (p = .029, r = .327).ConclusionIncreased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. Abstract Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti‐CCP) antibodies and disease activity. Methods Forty‐five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real‐time PCR (qRT‐PCR), and anti‐CCP antibodies plasma levels were measured using the enzyme‐linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score‐28 (DAS‐28) formula. Results The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS‐28 (p = .006, r = .402), anti‐CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS‐28 (p = .037, r = .310), plasma levels of anti‐CCP (p = .037, r = .312), and ESR (p = .029, r = .327). Conclusion Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. Abstract Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti‐CCP) antibodies and disease activity. Methods Forty‐five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real‐time PCR (qRT‐PCR), and anti‐CCP antibodies plasma levels were measured using the enzyme‐linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score‐28 (DAS‐28) formula. Results The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls ( p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 ( p = .001, r = .461), plasma levels of CCL20 ( p = .0009, r = .477), ESR ( p = .004, r = .419), DAS‐28 ( p = .006, r = .402), anti‐CCP ( p = .019, r = .346), and RF ( p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS‐28 ( p = .037, r = .310), plasma levels of anti‐CCP ( p = .037, r = .312), and ESR ( p = .029, r = .327). Conclusion Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor-related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti-CCP) antibodies and disease activity. Forty-five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real-time PCR (qRT-PCR), and anti-CCP antibodies plasma levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score-28 (DAS-28) formula. The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS-28 (p = .006, r = .402), anti-CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS-28 (p = .037, r = .310), plasma levels of anti-CCP (p = .037, r = .312), and ESR (p = .029, r = .327). Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor-related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti-CCP) antibodies and disease activity.OBJECTIVESThe significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor-related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti-CCP) antibodies and disease activity.Forty-five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real-time PCR (qRT-PCR), and anti-CCP antibodies plasma levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score-28 (DAS-28) formula.METHODSForty-five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real-time PCR (qRT-PCR), and anti-CCP antibodies plasma levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score-28 (DAS-28) formula.The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS-28 (p = .006, r = .402), anti-CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS-28 (p = .037, r = .310), plasma levels of anti-CCP (p = .037, r = .312), and ESR (p = .029, r = .327).RESULTSThe gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS-28 (p = .006, r = .402), anti-CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS-28 (p = .037, r = .310), plasma levels of anti-CCP (p = .037, r = .312), and ESR (p = .029, r = .327).Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA.CONCLUSIONIncreased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti‐CCP) antibodies and disease activity. Methods Forty‐five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real‐time PCR (qRT‐PCR), and anti‐CCP antibodies plasma levels were measured using the enzyme‐linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score‐28 (DAS‐28) formula. Results The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS‐28 (p = .006, r = .402), anti‐CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS‐28 (p = .037, r = .310), plasma levels of anti‐CCP (p = .037, r = .312), and ESR (p = .029, r = .327). Conclusion Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA. The gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls. Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6, plasma levels of CCL20, ESR, DAS‐28, anti‐CCP, and RF. Also, CCR6 gene expression was positively associated with the DAS‐28, plasma levels of anti‐CCP, and ESR. Increased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA |
Author | Roghani, Seyed Askar Soufivand, Parviz Taghadosi, Mahdi Pournazari, Mehran Lotfi, Ramin Khorasanizadeh, Ali Feizollahi, Parisa Assar, Shirin Soroush, Masood Ghasemzade Mohammadi Kish, Zahra |
Author_xml | – sequence: 1 givenname: Seyed Askar surname: Roghani fullname: Roghani, Seyed Askar organization: Kermanshah University of Medical Sciences – sequence: 2 givenname: Ramin orcidid: 0000-0002-5421-5280 surname: Lotfi fullname: Lotfi, Ramin organization: Kurdistan University of Medical Sciences – sequence: 3 givenname: Masood Ghasemzade surname: Soroush fullname: Soroush, Masood Ghasemzade organization: Kermanshah University of Medical Sciences – sequence: 4 givenname: Ali surname: Khorasanizadeh fullname: Khorasanizadeh, Ali organization: Ahvaz Jundishapur University of Medical Sciences – sequence: 5 givenname: Parisa surname: Feizollahi fullname: Feizollahi, Parisa organization: Kermanshah University of Medical Sciences – sequence: 6 givenname: Shirin surname: Assar fullname: Assar, Shirin organization: Kermanshah University of Medical Sciences – sequence: 7 givenname: Parviz surname: Soufivand fullname: Soufivand, Parviz organization: Kermanshah University of Medical Sciences – sequence: 8 givenname: Mehran surname: Pournazari fullname: Pournazari, Mehran organization: Kermanshah University of Medical Sciences – sequence: 9 givenname: Zahra surname: Mohammadi Kish fullname: Mohammadi Kish, Zahra organization: Kermanshah University of Medical Sciences – sequence: 10 givenname: Mahdi orcidid: 0000-0002-3516-0130 surname: Taghadosi fullname: Taghadosi, Mahdi email: mtaghad@gmail.com organization: Kermanshah University of Medical Sciences |
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Cites_doi | 10.1016/j.autrev.2021.102846 10.1016/j.cyto.2015.02.002 10.1371/journal.pone.0042189 10.1186/s13075-015-0606-5 10.1038/s41584-020-00541-7 10.1084/jem.20071397 10.1136/ard.2006.054205 10.1186/ar395 10.1186/s13075-017-1401-2 10.1038/icb.2013.97 10.1093/nar/29.9.e45 10.1080/14397595.2017.1416923 10.1038/s41584-021-00663-6 10.1146/annurev.immunol.021908.132710 10.1038/ncprheum0047 10.1016/0092-8674(95)90200-7 10.1038/ng.583 10.1038/sj.gene.6364045 10.1038/nrrheum.2015.157 10.1002/eji.201242740 10.1002/eji.201948112 10.1007/s00109-014-1232-4 10.3109/s10165-008-0099-z 10.1016/S1044-5323(02)00124-0 10.1111/j.1600-065X.2008.00628.x 10.1126/sciadv.abn7774 10.1093/rheumatology/kes279 10.1002/art.30093 10.1038/s41467-020-16820-6 10.1038/s41419-020-02891-2 10.1038/nri2094 10.1111/febs.14466 10.2147/ITT.S243636 10.1007/s10067-021-05899-x 10.1002/art.22868 |
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Copyright | 2023 The Authors. published by John Wiley & Sons Ltd. 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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References | 2018; 285 2018; 28 2014; 92 2015; 17 2021; 20 2007; 204 2015; 93 2008; 18 2015; 74 2003; 15 2004; 5 2002; 4 2022; 41 2020; 11 2008; 223 2001; 29 2015; 8 2007; 56 2009; 27 2016; 12 2012; 51 2010; 42 1995; 83 2020; 50 2021; 17 2022; 8 2000; 52 2020; 9 2011; 63 2007; 7 2005; 1 2017; 19 2012; 7 2007; 66 2012; 42 e_1_2_11_10_1 e_1_2_11_32_1 e_1_2_11_31_1 e_1_2_11_36_1 e_1_2_11_14_1 e_1_2_11_13_1 e_1_2_11_35_1 e_1_2_11_12_1 e_1_2_11_34_1 e_1_2_11_11_1 e_1_2_11_33_1 e_1_2_11_7_1 e_1_2_11_29_1 e_1_2_11_6_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_4_1 e_1_2_11_26_1 e_1_2_11_3_1 e_1_2_11_2_1 Murphy PM (e_1_2_11_27_1) 2000; 52 Cheng P (e_1_2_11_30_1) 2015; 8 e_1_2_11_21_1 e_1_2_11_20_1 e_1_2_11_25_1 e_1_2_11_24_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_8_1 e_1_2_11_22_1 e_1_2_11_18_1 e_1_2_11_17_1 e_1_2_11_16_1 e_1_2_11_15_1 e_1_2_11_37_1 e_1_2_11_38_1 e_1_2_11_19_1 |
References_xml | – volume: 11 start-page: 697 issue: 8 year: 2020 article-title: Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation publication-title: Cell Death Dis – volume: 52 start-page: 145 issue: 1 year: 2000 end-page: 176 article-title: International union of pharmacology. XXII. nomenclature for chemokine receptors publication-title: Pharmacol Rev – volume: 15 start-page: 15 issue: 1 year: 2003 end-page: 21 article-title: Chemokines and chemokine receptors in rheumatoid arthritis publication-title: Semin Immunol – volume: 7 issue: 8 year: 2012 article-title: Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti‐CCP seropositivity publication-title: PLoS One – volume: 66 start-page: 407 issue: 3 year: 2007 end-page: 409 article-title: Comparison of Disease Activity Score (DAS)28‐erythrocyte sedimentation rate and DAS28‐C‐reactive protein threshold values publication-title: Ann Rheum Dis – volume: 8 start-page: 5388 issue: 4 year: 2015 end-page: 5396 article-title: Association between CCR6 and rheumatoid arthritis: a meta‐analysis publication-title: Int J Clin Exp Med – volume: 27 start-page: 485 year: 2009 end-page: 517 article-title: IL‐17 and Th17 cells publication-title: Annu Rev Immunol – volume: 18 start-page: 533 issue: 6 year: 2008 end-page: 541 article-title: New complexities in helper T cell fate determination and the implications for autoimmune diseases publication-title: Mod Rheumatol – volume: 17 start-page: 441 issue: 8 year: 2021 article-title: Targeting the CCR6‐CCL20 axis improves experimental PsA publication-title: Nat Rev Rheumatol – volume: 29 issue: 9 year: 2001 article-title: A new mathematical model for relative quantification in real‐time RT‐PCR publication-title: Nucleic Acids Res – volume: 20 issue: 7 year: 2021 article-title: CCR6‐CCL20 axis as a therapeutic target for autoimmune diseases publication-title: Autoimmun Rev – volume: 93 start-page: 457 issue: 4 year: 2015 end-page: 467 article-title: The pathogenic Th profile of human activated memory Th cells in early rheumatoid arthritis can be modulated by VIP publication-title: J Mol Med – volume: 41 start-page: 265 issue: 1 year: 2022 end-page: 270 article-title: Increased plasma levels of CCL20 in peripheral blood of rheumatoid arthritis patients and its association with clinical and laboratory parameters publication-title: Clin Rheumatol – volume: 8 issue: 34 year: 2022 article-title: RORγt expression in mature T(H)17 cells safeguards their lineage specification by inhibiting conversion to T(H)2 cells publication-title: Sci Adv – volume: 51 start-page: vi5 issue: suppl 6 year: 2012 end-page: vi9 article-title: ACR/EULAR 2010 rheumatoid arthritis classification criteria publication-title: Rheumatology – volume: 5 start-page: 151 issue: 3 year: 2004 end-page: 157 article-title: A review of the MHC genetics of rheumatoid arthritis publication-title: Genes Immun – volume: 19 start-page: 194 issue: 1 year: 2017 article-title: High titers of both rheumatoid factor and anti‐CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study publication-title: Arthritis Res Ther – volume: 92 start-page: 354 issue: 4 year: 2014 end-page: 358 article-title: CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis publication-title: Immunol Cell Biol – volume: 50 start-page: 245 issue: 2 year: 2020 end-page: 255 article-title: CD4(+) CCR6(+) T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice publication-title: Eur J Immunol – volume: 285 start-page: 2944 issue: 16 year: 2018 end-page: 2971 article-title: A guide to chemokines and their receptors publication-title: FEBS J – volume: 4 start-page: 87 issue: 2 year: 2002 end-page: 93 article-title: Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value publication-title: Arthritis Res – volume: 9 start-page: 43 year: 2020 end-page: 56 article-title: Role of chemokines and chemokine receptors in rheumatoid arthritis publication-title: Immunotargets Ther – volume: 56 start-page: 2929 issue: 9 year: 2007 end-page: 2935 article-title: The performance of anti‐cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register publication-title: Arthritis Rheum – volume: 63 start-page: 73 issue: 1 year: 2011 end-page: 83 article-title: Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin‐17A production publication-title: Arthritis Rheum – volume: 17 start-page: 17 issue: 1 year: 2021 end-page: 33 article-title: Persistent inflammatory and non‐inflammatory mechanisms in refractory rheumatoid arthritis publication-title: Nat Rev Rheumatol – volume: 83 start-page: 841 issue: 6 year: 1995 end-page: 850 article-title: The RXR heterodimers and orphan receptors publication-title: Cell – volume: 42 start-page: 2232 issue: 9 year: 2012 end-page: 2237 article-title: Small molecule inhibitors of RORγt: targeting Th17 cells and other applications publication-title: Eur J Immunol – volume: 42 start-page: 515 issue: 6 year: 2010 end-page: 519 article-title: A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility publication-title: Nat Genet – volume: 11 start-page: 3031 issue: 1 year: 2020 article-title: Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20 publication-title: Nat Commun – volume: 74 start-page: 43 issue: 1 year: 2015 end-page: 53 article-title: The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis publication-title: Cytokine – volume: 28 start-page: 814 issue: 5 year: 2018 end-page: 825 article-title: The RORγt‐CCR6‐CCL20 axis augments Th17 cells invasion into the synovia of rheumatoid arthritis patients publication-title: Mod Rheumatol – volume: 7 start-page: 429 issue: 6 year: 2007 end-page: 442 article-title: Cytokines in the pathogenesis of rheumatoid arthritis publication-title: Nat Rev Immunol – volume: 17 start-page: 105 issue: 1 year: 2015 article-title: Involvement of RORγt‐overexpressing T cells in the development of autoimmune arthritis in mice publication-title: Arthritis Res Ther – volume: 204 start-page: 2803 issue: 12 year: 2007 end-page: 2812 article-title: Preferential recruitment of CCR6‐expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model publication-title: J Exp Med – volume: 1 start-page: 102 issue: 2 year: 2005 end-page: 110 article-title: Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis publication-title: Nat Clin Pract Rheumatol – volume: 12 start-page: 5 issue: 1 year: 2016 end-page: 13 article-title: Successes and failures of chemokine‐pathway targeting in rheumatoid arthritis publication-title: Nat Rev Rheumatol – volume: 223 start-page: 87 year: 2008 end-page: 113 article-title: Th17 cells in human disease publication-title: Immunol Rev – ident: e_1_2_11_35_1 doi: 10.1016/j.autrev.2021.102846 – ident: e_1_2_11_12_1 doi: 10.1016/j.cyto.2015.02.002 – ident: e_1_2_11_26_1 doi: 10.1371/journal.pone.0042189 – ident: e_1_2_11_38_1 doi: 10.1186/s13075-015-0606-5 – ident: e_1_2_11_3_1 doi: 10.1038/s41584-020-00541-7 – ident: e_1_2_11_31_1 doi: 10.1084/jem.20071397 – ident: e_1_2_11_22_1 doi: 10.1136/ard.2006.054205 – ident: e_1_2_11_7_1 doi: 10.1186/ar395 – volume: 8 start-page: 5388 issue: 4 year: 2015 ident: e_1_2_11_30_1 article-title: Association between CCR6 and rheumatoid arthritis: a meta‐analysis publication-title: Int J Clin Exp Med contributor: fullname: Cheng P – ident: e_1_2_11_33_1 doi: 10.1186/s13075-017-1401-2 – ident: e_1_2_11_15_1 doi: 10.1038/icb.2013.97 – volume: 52 start-page: 145 issue: 1 year: 2000 ident: e_1_2_11_27_1 article-title: International union of pharmacology. XXII. nomenclature for chemokine receptors publication-title: Pharmacol Rev contributor: fullname: Murphy PM – ident: e_1_2_11_21_1 doi: 10.1093/nar/29.9.e45 – ident: e_1_2_11_34_1 doi: 10.1080/14397595.2017.1416923 – ident: e_1_2_11_29_1 doi: 10.1038/s41584-021-00663-6 – ident: e_1_2_11_13_1 doi: 10.1146/annurev.immunol.021908.132710 – ident: e_1_2_11_2_1 doi: 10.1038/ncprheum0047 – ident: e_1_2_11_36_1 doi: 10.1016/0092-8674(95)90200-7 – ident: e_1_2_11_16_1 doi: 10.1038/ng.583 – ident: e_1_2_11_4_1 doi: 10.1038/sj.gene.6364045 – ident: e_1_2_11_8_1 doi: 10.1038/nrrheum.2015.157 – ident: e_1_2_11_37_1 doi: 10.1002/eji.201242740 – ident: e_1_2_11_32_1 doi: 10.1002/eji.201948112 – ident: e_1_2_11_24_1 doi: 10.1007/s00109-014-1232-4 – ident: e_1_2_11_25_1 doi: 10.3109/s10165-008-0099-z – ident: e_1_2_11_6_1 doi: 10.1016/S1044-5323(02)00124-0 – ident: e_1_2_11_14_1 doi: 10.1111/j.1600-065X.2008.00628.x – ident: e_1_2_11_18_1 doi: 10.1126/sciadv.abn7774 – ident: e_1_2_11_20_1 doi: 10.1093/rheumatology/kes279 – ident: e_1_2_11_23_1 doi: 10.1002/art.30093 – ident: e_1_2_11_28_1 doi: 10.1038/s41467-020-16820-6 – ident: e_1_2_11_17_1 doi: 10.1038/s41419-020-02891-2 – ident: e_1_2_11_5_1 doi: 10.1038/nri2094 – ident: e_1_2_11_9_1 doi: 10.1111/febs.14466 – ident: e_1_2_11_10_1 doi: 10.2147/ITT.S243636 – ident: e_1_2_11_11_1 doi: 10.1007/s10067-021-05899-x – ident: e_1_2_11_19_1 doi: 10.1002/art.22868 |
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The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies.... The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid... Abstract Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many... ObjectivesThe significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies.... Abstract Objectives The significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many... |
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SubjectTerms | anti‐CCP Biotechnology Body mass index CCR6 Chemokines DAS‐28 Disease Gene expression Leukocytes Ligands Pathogenesis Peptides Plasma Rheumatoid arthritis RORγt Software Statistical analysis Thermal cycling |
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Title | Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity |
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