Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D

The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14–16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. Th...

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Published inBritish journal of clinical pharmacology Vol. 84; no. 10; pp. 2194 - 2207
Main Authors Sempos, Christopher T., Heijboer, Annemieke C., Bikle, Daniel D., Bollerslev, Jens, Bouillon, Roger, Brannon, Patsy M., DeLuca, Hector F., Jones, Glenville, Munns, Craig F., Bilezikian, John P., Giustina, Andrea, Binkley, Neil
Format Journal Article
LanguageEnglish
Published England John Wiley and Sons Inc 01.10.2018
Subjects
25‐hydroxyvitamin D
Consensus Development Conferences as Topic
Fibroblast Growth Factor (FGF23)
Humans
Parathyroid Hormone (PTH)
Practice Guidelines as Topic
Reference Standards
Review
Reviews
Vitamin D
Vitamin D - blood
Vitamin D - standards
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Standardization Program (VDSP)
Vitamin D‐binding protein (DBP)
Parathyroid Hormone (PTH)
Fibroblast Growth Factor (FGF23)
Vitamin D Standardization Program (VDSP)
25-hydroxyvitamin D
Vitamin D
Vitamin D-binding protein (DBP)
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Abstract The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14–16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25‐hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2D3, 3‐epi‐25(OH)D, 24,25(OH)2D3, vitamin D‐binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml–1 (30 nmol l–1) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml–1 and 50 ng ml–1 (50–125 nmol l–1) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
AbstractList The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25-hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D and 25(OH)D ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH) D , 3-epi-25(OH)D, 24,25(OH) D vitamin D-binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml (30 nmol l ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml and 50 ng ml (50-125 nmol l ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14–16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25‐hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D 3 and 25(OH)D 2 ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH) 2 D 3 , 3‐epi‐25(OH)D, 24,25(OH) 2 D 3, vitamin D‐binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml –1 (30 nmol l –1 ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml –1 and 50 ng ml –1 (50–125 nmol l –1 ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25-hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2 ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2 D3 , 3-epi-25(OH)D, 24,25(OH)2 D3, vitamin D-binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml-1 (30 nmol l-1 ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml-1 and 50 ng ml-1 (50-125 nmol l-1 ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25-hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2 ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2 D3 , 3-epi-25(OH)D, 24,25(OH)2 D3, vitamin D-binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml-1 (30 nmol l-1 ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml-1 and 50 ng ml-1 (50-125 nmol l-1 ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14–16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25‐hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2D3, 3‐epi‐25(OH)D, 24,25(OH)2D3, vitamin D‐binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml–1 (30 nmol l–1) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml–1 and 50 ng ml–1 (50–125 nmol l–1) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
Author Bouillon, Roger
Jones, Glenville
Bilezikian, John P.
Brannon, Patsy M.
Heijboer, Annemieke C.
Bollerslev, Jens
Binkley, Neil
Bikle, Daniel D.
Giustina, Andrea
Sempos, Christopher T.
DeLuca, Hector F.
Munns, Craig F.
AuthorAffiliation 4 San Francisco, San Francisco Department of Veterans Affairs Medical Center, Endocrine Research Unit University of California San Francisco CA USA
7 Department of Chronic Diseases, Metabolism and Ageing Laboratory of Clinical and Experimental Endocrinology KU Leuven Belgium
1 Vitamin D Standardization Program Havre de Grace MD USA
3 Laboratory of Endocrinology Academic Medical Center Amsterdam The Netherlands
11 Institute of Endocrinology and Diabetes The Children's Hospital at Westmead Sydney NSW Australia
6 Faculty of Medicine University of Oslo Oslo Norway
10 Department of Biomedical and Molecular Sciences Queen's University Kingston ON Canada
13 Division of Endocrinology San Raffaele University Hospital Milan Italy
14 Osteoporosis Clinical Research Program and Institute on Aging University of Wisconsin‐Madison Madison WI USA
9 Department of Biochemistry University of Wisconsin‐Madison Madison WI USA
8 Division of Nutritional Sciences Cornell University Ithaca NY USA
12 Department of Medicine
AuthorAffiliation_xml – name: 8 Division of Nutritional Sciences Cornell University Ithaca NY USA
– name: 12 Department of Medicine, Endocrinology Division, College of Physicians and Surgeons Columbia University New York NY USA
– name: 11 Institute of Endocrinology and Diabetes The Children's Hospital at Westmead Sydney NSW Australia
– name: 1 Vitamin D Standardization Program Havre de Grace MD USA
– name: 5 Section of Specialized Endocrinology, Department of Endocrinology Oslo University Hospital, Rikshospitalet Oslo Norway
– name: 4 San Francisco, San Francisco Department of Veterans Affairs Medical Center, Endocrine Research Unit University of California San Francisco CA USA
– name: 14 Osteoporosis Clinical Research Program and Institute on Aging University of Wisconsin‐Madison Madison WI USA
– name: 2 Endocrine Laboratory, Department of Clinical Chemistry VU University Medical Center Amsterdam The Netherlands
– name: 9 Department of Biochemistry University of Wisconsin‐Madison Madison WI USA
– name: 6 Faculty of Medicine University of Oslo Oslo Norway
– name: 10 Department of Biomedical and Molecular Sciences Queen's University Kingston ON Canada
– name: 3 Laboratory of Endocrinology Academic Medical Center Amsterdam The Netherlands
– name: 13 Division of Endocrinology San Raffaele University Hospital Milan Italy
– name: 7 Department of Chronic Diseases, Metabolism and Ageing Laboratory of Clinical and Experimental Endocrinology KU Leuven Belgium
Author_xml – sequence: 1
  givenname: Christopher T.
  orcidid: 0000-0003-1324-3282
  surname: Sempos
  fullname: Sempos, Christopher T.
  email: semposch@gmail.com
  organization: Vitamin D Standardization Program
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  givenname: Annemieke C.
  surname: Heijboer
  fullname: Heijboer, Annemieke C.
  organization: Academic Medical Center
– sequence: 3
  givenname: Daniel D.
  surname: Bikle
  fullname: Bikle, Daniel D.
  organization: University of California
– sequence: 4
  givenname: Jens
  surname: Bollerslev
  fullname: Bollerslev, Jens
  organization: University of Oslo
– sequence: 5
  givenname: Roger
  surname: Bouillon
  fullname: Bouillon, Roger
  organization: Laboratory of Clinical and Experimental Endocrinology
– sequence: 6
  givenname: Patsy M.
  surname: Brannon
  fullname: Brannon, Patsy M.
  organization: Cornell University
– sequence: 7
  givenname: Hector F.
  surname: DeLuca
  fullname: DeLuca, Hector F.
  organization: University of Wisconsin‐Madison
– sequence: 8
  givenname: Glenville
  surname: Jones
  fullname: Jones, Glenville
  organization: Queen's University
– sequence: 9
  givenname: Craig F.
  surname: Munns
  fullname: Munns, Craig F.
  organization: The Children's Hospital at Westmead
– sequence: 10
  givenname: John P.
  surname: Bilezikian
  fullname: Bilezikian, John P.
  organization: Columbia University
– sequence: 11
  givenname: Andrea
  surname: Giustina
  fullname: Giustina, Andrea
  organization: San Raffaele University Hospital
– sequence: 12
  givenname: Neil
  surname: Binkley
  fullname: Binkley, Neil
  organization: University of Wisconsin‐Madison
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29851137$$D View this record in MEDLINE/PubMed
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Issue 10
Keywords Parathyroid Hormone (PTH)
Fibroblast Growth Factor (FGF23)
Vitamin D Standardization Program (VDSP)
25-hydroxyvitamin D
Vitamin D
Vitamin D-binding protein (DBP)
Language English
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2018 The British Pharmacological Society.
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Snippet The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14–16 June 2017. The meeting's purpose was to address controversies...
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies...
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SubjectTerms 25‐hydroxyvitamin D
Consensus Development Conferences as Topic
Fibroblast Growth Factor (FGF23)
Humans
Parathyroid Hormone (PTH)
Practice Guidelines as Topic
Reference Standards
Review
Reviews
Vitamin D
Vitamin D - blood
Vitamin D - standards
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Standardization Program (VDSP)
Vitamin D‐binding protein (DBP)
Title Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbcp.13652
https://www.ncbi.nlm.nih.gov/pubmed/29851137
https://www.proquest.com/docview/2047930236
https://pubmed.ncbi.nlm.nih.gov/PMC6138489
Volume 84
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