Topical administration of regorafenib eye drops: phase I dose‐escalation study in healthy volunteers - Zimmermann, Torsten; Höchel, Joachim; Becka, Michael; Boettger, Michael K.; Rohde, Beate; Schug, Barbara; Kunert, Kathleen S.; Donath, Frank (British journal of clinical pharmacology, 2018)
Keywords: Administration, Ophthalmic; Administration, Oral; Adolescent; Adult; Clinical Trials; convenience; Dose-Response Relationship, Drug; Double-Blind Method; eye drops; Healthy Volunteers; Humans; Male; Middle Aged; neovascular age‐related macular degeneration; Ophthalmic Solutions - adverse effects; Ophthalmic Solutions - pharmacokinetics; pharmacokinetics; Phenylurea Compounds - administration & dosage; Phenylurea Compounds - adverse effects; Phenylurea Compounds - blood; Phenylurea Compounds - pharmacokinetics; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - adverse effects; Protein Kinase Inhibitors - blood; Protein Kinase Inhibitors - pharmacokinetics; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - blood; Pyridines - pharmacokinetics; regorafenib; safety; Young Adult; eye drops; neovascular age-related macular degeneration; pharmacokinetics; convenience; regorafenib; safety